Superparamagnetism microsphere and method for manufacturing the same

A superparamagnetic and microsphere technology, which is applied in the direction of the magnetism of inorganic materials, can solve the problem of difficulty in controlling the content of microsphere magnetic ferric oxide particles, difficulty in synthesizing large-diameter magnetic polymer microspheres, and low yield of finished products. problems, to achieve the effect of easy organization of mass production, maintenance of chemical and physical stability, and low production cost

Active Publication Date: 2009-08-26
JIANGSU ZECEN BIOTECH CO LTD
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AI Technical Summary

Problems solved by technology

[0004] The current common related polymerization method is to thermally initiate the polymerization of vinyl monomers in the presence of a surfactant-stabilized magnetic fluid. On the one hand, this method is difficult to synthesize large-size magnetic polymer microspheres. The solids do not necessarily aggregate around the magnetic ferroferric oxide particles, so that the content of the synthesized microsphere magnetic ferroferric oxide particles is not easy to control. The magnetic content is uneven, even some microspheres are non-magnetic, and the output rate of finished products is low.

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  • Superparamagnetism microsphere and method for manufacturing the same
  • Superparamagnetism microsphere and method for manufacturing the same
  • Superparamagnetism microsphere and method for manufacturing the same

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preparation example Construction

[0030] 1. A method for preparing superparamagnetic microspheres, comprising the following steps:

[0031] A. Prepare metal ion solution;

[0032] B. Under vacuum or nitrogen protection and room temperature conditions, soak the dry porous or hollow microspheres in the metal ion solution for 18-24 hours, and then under vacuum or nitrogen protection, rotary evaporation at 20-60 degrees Celsius until the metal ions The water in the solution evaporates completely;

[0033] C. Add ammonia water or sodium hydroxide solution at 30-50 degrees Celsius to the evaporated porous or hollow microspheres, control the pH value to 9-11, raise the temperature to 60-90 degrees Celsius, stir for 10-50 minutes, and let stand to cool to room temperature , to separate porous or hollow magnetic microspheres from the solution under the action of a magnetic field;

[0034] D. Wash the porous or hollow magnetic microspheres with alcohol, add surfactant Tween-20 according to the ratio of porous or hollo...

Embodiment 1

[0044] Embodiment 1: Utilize solution polymerization to prepare the polymer dispersant of small molecular weight

[0045] The polymerization reaction is carried out in a three-neck flask equipped with a reflux condenser, stirring, and feeding device under nitrogen protection, and the reaction temperature is controlled at about 60 degrees Celsius. Add 150 milliliters of water, 5 milliliters of acrylic acid, and 1 gram of sodium chloride into a 250 milliliter there-necked flask and stir at a constant temperature for 10-15 minutes, then gradually add 5 milliliters of an initiator potassium persulfate aqueous solution with a mass fraction of 5%, and the polymerization reaction begins. React for 10-15 hours, cool, wash with alcohol water three times to remove sodium chloride, and obtain a stable polyacrylic acid latex solution. The above-mentioned typical dispersion polymerization method can also be used to prepare dispersant solutions such as polymethacrylic acid, polyacrylamide o...

Embodiment 2

[0046] Example 2: Preparation of monodisperse polymer microspheres by dispersion polymerization

[0047] Add double-distilled water, absolute ethanol, the polyacrylic acid latex solution and styrene in Example 1 respectively to a 250-milliliter three-necked flask equipped with a stirrer, a thermometer and a condenser, fill with nitrogen, and start stirring under nitrogen protection conditions ; Slowly heat up, after reaching 70-80 degrees Celsius, add azobisisobutyronitrile to start the reaction, after constant temperature reaction for 18-24 hours, cool and discharge. The polymer product is centrifuged, washed thoroughly with methanol, and dried to obtain polymer microspheres. Wherein the characteristic formula ratio is: the ratio of styrene accounts for 10.03% of the overall mass, absolute ethanol accounts for 68.56% of the overall mass, twice distilled water accounts for 20.4% of the overall mass, azobisisobutyronitrile accounts for 1.68% of the monomer, Polyacrylic acid ac...

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Abstract

A kind of superparamagnetic microsphere and preparation method thereof, under the condition of vacuum or nitrogen protection and room temperature, soak porous or hollow microsphere in metal ion solution, rotary evaporation, add ammonia water or sodium hydroxide solution, stir reaction, magnetic field Isolate porous or hollow magnetic microspheres, wash them with alcohol, add surfactant, isopropanol, ammonia water and ethyl orthosilicate to obtain superparamagnetic microspheres coated with silicon dioxide, which can also be used on the surface of microspheres Selectively assemble various functional groups. The inner pores of the microspheres have good compatibility with metal ions, the magnetic nanoparticles are evenly distributed, have good superparamagnetism, chemical and physical stability, acid and alkali resistance, and are not easy to oxidize or agglomerate. The process is simple, less equipment is required, the control is convenient, the output rate is high, the production cost is low, and it is easy to organize mass production.

Description

Technical field [0001] The invention relates to a magnetic organic-inorganic hybrid material and a preparation method thereof, in particular to an organic-inorganic hybrid superparamagnetic microsphere and a preparation method thereof. Background technique [0002] As a new type of functional polymer material, magnetic polymer microspheres have a very wide range of applications in biomedicine such as clinical diagnosis, enzyme labeling, targeted drugs, cytology such as cell labeling, cell separation, and bioengineering such as enzyme immobilization. For the application prospect, some foreign scholars refer to it as a dynamic particle (dynabead). How to prepare monodisperse superparamagnetic polymer microspheres is an important research field in chemistry and material science. [0003] The prior art methods for synthesizing magnetic polymer composite microspheres mainly include polymer embedding, chemical transformation and monomer polymerization. Among them, the preparatio...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): H01F1/36B22F1/02C04B35/26C04B35/628
Inventor 刘祖黎李岳彬杜桂焕夏星周弦
Owner JIANGSU ZECEN BIOTECH CO LTD
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