Yao horsefly salivary gland immunoregulation peptide, gene and application thereof

A technology of immune regulation and salivary glands, which is applied in the field of biomedicine, can solve problems such as no public reports, and achieve the effects of strong antibacterial activity, simple structure, and convenient artificial synthesis
CN101220091AActive Publication Date: 2008-07-16KUNMING INST OF ZOOLOGY CHINESE ACAD OF SCI
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
KUNMING INST OF ZOOLOGY CHINESE ACAD OF SCI
Publication Date
2008-07-16

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Abstract

The invention relates to a salivary gland immunoregulation polypeptide of a dieu cleg and the related genes and the application, belonging to the biomedical field. The immunoregulation polypeptide is a linear polypeptide coded with the Chinese Tabanidae salivary gland immunoregulation polypeptide genes, the sequence of which is glycin- glycin- valine- serine- glycin- valine- serine- aspartic acid- phenylalanine- glutamate- praline- isoleucine- glutamate- valine- serine- glycin- glutamate- aspartic acid- tyrosine- aspartic acid- serine- aspartic acid- glutamate- alanine- aspartic acid- glutamate- aspartic acid- glycin- lysine- alanine. The immunoregulation polypeptide gene is composed of 362 Nucleotides, wherein, the coding mature code salivary gland immunoregulation polypeptide of the dieu cleg is the 115th to the 204th nucleotide. The dieu cleg salivary gland immunoregulation polypeptide is used for inhibiting a plurality of cytokines, which is characterized by simple structure, convenient artificial synthesis and strong antibacterial activity, etc.
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Description

Technical field:

[0001] The invention provides a Yaofly salivary gland immunomodulatory peptide and its gene and application, which belong to the technical field of biomedicine. Background technique:

[0002] Immunomodulatory peptides have a wide range of biological activities at their physiological concentrations, in the presence of salt and serum, including in innate immune cells (neutrophils, epithelial cells) and inflammatory responses, innate immunity and adaptive Immune-related activity in monocytes, macrophages, and dendritic cells as a bridge between innate and adaptive immunity. Antimicrobial peptides can neutralize G - Lipopolysaccharide, G + Bacterial signaling molecules such as lipoteichoic acid and bacterial unmethylated CpG DNA. These signaling molecules can bind to Toll-like receptors on the surface of host cells to initiate signal cascade amplification and positive regulation of cytokines (such as TNF-α, IL-6, etc.). Low concentrations of bacterial signal...

Claims

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