Blood filtering replacement liquid prescription special for anti congealing

A technology of replacement fluid and hemofiltration, which is applied to the formulation and preparation of hemofiltration replacement fluid for anticoagulation, and the formulation and preparation of hemofiltration replacement fluid for citrate anticoagulation, which can solve the problem of fever and drug leakage. Liquid, compatibility troubles and other problems

Inactive Publication Date: 2008-09-03
SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0059] (4) A large amount of rehydration is required in the anuric state;
[0063] (2) Hemodynamic instability;
[0086] (1) Use with caution in patients with lactate intolerance
[0087] (2) Squeeze the plastic bag hard before use, and check it carefully. If there is leakage or the liquid is not clear, do not use it.
[0089] (4) Uncleanness, damage or repeated use of pipeline instruments and low temperature may easily cause infusion reactions

Method used

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  • Blood filtering replacement liquid prescription special for anti congealing
  • Blood filtering replacement liquid prescription special for anti congealing
  • Blood filtering replacement liquid prescription special for anti congealing

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0465] Example 1 Typical Case 1

[0466] Patient Wang, a car accident caused multiple injuries, and acute renal failure was caused by hypotension. Due to the patient's renal failure and anuria, antibiotics, fluid supplementation and intravenous nutrition were needed at the same time. A large amount of fluids needed to be supplemented every day, and toxins in the patient's body also needed to be removed Therefore, continuous renal replacement (support) treatment is used. Since the patient has multiple injuries, many surgical wound sites, and many bleeding / oozing sites, if unfractionated heparin or low molecular weight heparin is used, it may cause severe bleeding, so citrate replacement is used. Anticoagulant fluid, the patient was treated with the pre-dilution method, the flow rate of the dialysate was 1000ml / h, and the flow rate of the replacement fluid was 2000ml / h. The treatment continued for 24 hours, a total of 5 times. After 10 days, the patient gradually increased urine ...

Embodiment 2

[0467] Embodiment 2 typical case 2

[0468] Patient Li, with chronic renal failure and maintenance hemodialysis for 5 years, was admitted to the hospital due to cerebral hemorrhage. Due to a variety of conditions, the patient could not perform peritoneal dialysis. Later, the patient was complicated by pulmonary infection, high fever, unstable blood pressure, etc., and the patient needed daily dehydration ultrafiltration treatment to improve cerebral edema and promote nerve cell recovery. Acute hemodialysis is difficult to remove excess water in the patient's body in a short period of time, and it is easy to cause the patient's intracranial pressure to be unstable or even increased. Therefore, continuous venous venous hemodiafiltration treatment was chosen, and only heparin-free dialysis could be used. In this group, 2000ml / h of citric acid replacement solution was used, and the pre-replacement method was adopted. The dialysate was 1500ml / h, and each continuous treatment 20 to...

Embodiment 3

[0469] Embodiment 3 typical case 3

[0470] The patient had severe pancreatitis, respiratory dysfunction, systemic inflammatory response syndrome state, decreased urine output, mildly elevated muscle and liver, fever, significantly increased blood count, and complicated abdominal and gastrointestinal bleeding, and abdominal necrotic tissue was cleaned up Surgery, fresh surgical wound. In this group, 2000-4000ml / h of citric acid replacement fluid was adopted, and the pre-replacement method was adopted. The dialysate was 1000-1500ml / h, and the continuous treatment was 18-24 hours each time. The treatment method was adjusted according to the patient's electrolyte examination and blood gas conditions, including Replacement fluid volume, treatment time and volume of supplemented calcium gluconate. After nearly 1 month of treatment, the patient improved significantly. Later, he died due to repeated abdominal bleeding, multiple surgeries, aggravated renal failure, and infection com...

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Abstract

The invention relates to a formula of a blood filtration replacement fluid which is special for citrate anticoagulation, a preparation method and a usage thereof. With the components of sodium citrate, sodium chloride, potassium chloride, sodium lactate, citric acid and so on, the replacement fluid is mainly used for blood filtration and blood dialysis filtration of the patients with acute renal failure or high risk bleeding due to multiple organ failure etc., and can solve the problems of easy occurrence of hypernatremia and alkali poisoning in the prior citrate anticoagulation, thus facilitating the clinical usage. The replacement fluid has the advantages of strong applicability, exact efficacy and low toxicity and side effects; the preparation process is simple; the quality is stable, safe and effective; the feasibility is strong; the repeatability is high; and the replacement fluid is applicable to the large-scale production and the promotion of the clinical application, thus being the ideal blood filtration replacement fluid for blood filtration, blood dialysis filtration, continuous renal replacement therapy and so on. The demand of the blood dialysis increases along with the increasing number of the patients with the end-stage renal failure year by year, so the blood filtration replacement fluid can generate more tremendous economic and social benefits.

Description

technical field [0001] The present invention relates to the technical fields of medicine, food and beverage, in particular to a formula for anticoagulant special blood filtration replacement fluid and its preparation method and use, more specifically to a citrate anticoagulant special blood The formulation of filter replacement solution and its preparation method and application. Background technique [0002] 1. Research progress of hemofiltration technology [0003] Hemofiltration is to imitate the filtration function of glomeruli. It uses a filter membrane with a larger pore size to uniformly filter out water and small molecule toxins in uremia from the body by the effect of transmembrane pressure. At the same time, it relies on infusion devices Simultaneously input the balance liquid with the same composition as the extracellular fluid, so as to remove the toxic substances in the blood through membrane filtration, that is, to remove small molecular substances and excess ...

Claims

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Application Information

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IPC IPC(8): A61L33/04A61L31/00A61M1/36
Inventor 叶朝阳张纯朴淑娟林厚文陈爱华梅长林
Owner SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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