Hydrophilic medicament dual-microsphere formulation and preparation method thereof
A technology of hydrophilic drugs and microspheres, which can be used in pharmaceutical formulations, medical preparations of non-active ingredients, powder delivery, etc. Rapid, increased drug loading, high encapsulation efficiency
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[0036] Example 1
[0037]Accurately weigh 30mg of gentamicin, dissolve it in 30ml of chitosan aqueous solution with a concentration of 1mg / mL and pH=6, stir magnetically at room temperature, and slowly add 12ml of sodium tripolyphosphate aqueous solution with a concentration of 0.5mg / mL to chitosan The sugar solution was mixed for 30 minutes, centrifuged at 12000 rpm at 4°C for 20 minutes, and the precipitate was collected, washed with distilled water 3 times, and freeze-dried to prepare chitosan nanoparticles.
[0038] Disperse the above-mentioned dried 50mg chitosan nanoparticles into 2.5ml acetonitrile solution containing 300mgPLGA (the mass ratio of LA to GA is 90:10), and mix it evenly by sonicating for 90 seconds with a 400w ultrasonic probe type as the suspended aqueous phase ; 1.5g of Span 80 dissolved in 20ml of edible oil as the oil phase; slowly drip the oil phase into the above-mentioned suspended aqueous phase under 3500rpm stirring, and rotary evaporate under reduced...
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[0039] Example 2
[0040] Accurately weigh 30 mg of streptomycin, and operate the rest in the same way as in Example 1.
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[0041] Example 3
[0042] Precisely weigh 250mg of tetracycline and dissolve it in 25ml of chitosan aqueous solution with a concentration of 3mg / mL and pH=4. Stir magnetically at room temperature. Slowly add 20ml of 1.5mg / mL sodium tripolyphosphate aqueous solution to the chitosan solution and mix. After 40 minutes, the precipitate was collected by centrifugation at 16000 rpm at 4°C for 20 minutes, washed with distilled water 3 times, and freeze-dried to prepare chitosan nanoparticles.
[0043] Disperse the above-mentioned dried 50mg chitosan nanoparticles into a 3ml acetonitrile solution containing 200mgPLGA (the mass ratio of LA to GA is 85:15), and mix them evenly by sonicating for 90 seconds with a 400w probe ultrasonic instrument as the suspended aqueous phase; Dissolve 2.0g Span 80 in 20ml edible oil as the oil phase. Under stirring at 3500rpm, slowly drop the oil phase into the above-mentioned suspended aqueous phase. Rotary evaporation under reduced pressure for 1.5 hours ...
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