Preparation of nano hydroxylapatite powder

A nano-hydroxyapatite and powder technology, applied in the chemical field, can solve the problems of unfavorable hydroxyapatite powder, complex production process, easy to leave residues, etc., and achieve convenient and easy purchase of raw materials, high purity, and particle size Narrow Effect

Inactive Publication Date: 2009-07-22
CHONGQING UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although some technologies can prepare hydroxyapatite powder with uniform size, the production process is relatively complicated.
Moreover, most existing technologies need to use mineralizers and templates, which tend to leave residues in the process, which is not conducive to obtaining completely harmless and non-toxic hydroxyapatite powder

Method used

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  • Preparation of nano hydroxylapatite powder
  • Preparation of nano hydroxylapatite powder
  • Preparation of nano hydroxylapatite powder

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Weigh 11.8055g of analytically pure calcium nitrate and 11.4146g of analytically pure dipotassium hydrogen phosphate, dissolve them in 50ml of distilled water respectively, and after stirring evenly, dilute the two solutions to 500ml with distilled water respectively. Calcium nitrate solution measures 183.7ml, and dipotassium hydrogen phosphate solution measures 110ml. After the two solutions are directly mixed, the pH value of the mixed solution is measured to be 5.20, and then the mixed solution is put into a reactor and heated at a stirring speed of 300 rpm. The reaction temperature is 200°C, the holding time is 0.5 hours, and it is cooled with the kettle. The reaction product was filtered using a water circulation vacuum pump, washed alternately with distilled water and ethanol six times, and dried in vacuum at a drying temperature of 85° C. for 5 hours. Characterized by XRD and TEM, the obtained hydroxyapatite particles are rod-shaped, about 200nm long, and the asp...

Embodiment 2

[0034] Weigh 4.3352g of analytically pure calcium nitrate and 2.5198g of analytically pure dipotassium hydrogen phosphate, and dissolve them in 183.7ml and 110.0ml of distilled water respectively. The dipotassium hydrogen phosphate solution was dropped into the calcium nitrate solution drop by drop with a dropper, and the glass rod was continuously stirred during the dropping process. Measure the pH value of the mixed solution to be 5.13, then pour it into the reaction kettle, the stirring speed is 180 rpm in the heating and heat preservation phase, and 100 rpm in the cooling phase, the reaction temperature is 200 ° C, the holding time is 3 hours, and it is cooled with the kettle . After the reaction, the precipitate was filtered with a water circulating vacuum pump, washed alternately with distilled water and ethanol for 5 times, and dried under an air atmosphere at a drying temperature of 78° C. and a drying time of 4.5 hours. Characterized by XRD and SEM, the obtained hydr...

Embodiment 3

[0036] Weigh 4.3426g of analytically pure calcium nitrate and 2.5263g of analytically pure dipotassium hydrogen phosphate, and dissolve them in 183.7ml and 110.0ml of distilled water respectively. The dipotassium hydrogen phosphate solution was dropped into the calcium nitrate solution drop by drop with a dropper, and the glass rod was continuously stirred during the dropping process. After measuring the pH value of the mixed solution, pour it into the reaction kettle, the stirring speed is 180 rpm, the reaction temperature is 200°C, the holding time is 9 hours, and it is cooled with the kettle. After the reaction, the precipitate was filtered with a water circulating vacuum pump, washed alternately with distilled water and ethanol three times, and dried under an air atmosphere at a drying temperature of 78° C. and a drying time of 4.5 hours. The obtained hydroxyapatite particles are rod-shaped with an aspect ratio of about 8.

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Abstract

The invention relates to a method for preparing a nanometer hydroxyl apatite powder by utilizing hydrothermal solution, which pertains to the chemical field. Cheap calcium nitrate and phosphate which are easy to purchase in the market are taken as raw materials, the two saline solutions are mixed in accordance with certain Ca / P ratio, after adjustment and mixing by using ammonia, the pH value of the suspension comes to a certain range and then the suspension is put into a reaction kettle; under the conditions of certain stirring speed, heating temperature and holding time, reaction happens and hydroxyl apatite is generated; and the acicular or bulbiform nanometer hydroxyl apatite powder is obtained after filtration, being cleaned by a certain solvent and drying under certain conditions. The preparation method is simple and easy to be operated and has good repeatability; the obtained power has high purity and narrow particle size range and is suitable for being popularized and applied in various fields such as hard tissue repair, wastewater treatment, chromatography filler, and the like.

Description

technical field [0001] The invention relates to a method for preparing nano-hydroxyapatite powder, specifically a method for preparing needle-shaped or spherical nano-hydroxyapatite by using hot liquid, and belongs to the field of chemistry. Background technique [0002] The research on nano-hydroxyapatite began in the 1990s. Due to its fine particle size and increased specific surface area, it exhibits better adsorption performance and biological activity than ordinary hydroxyapatite particles, and is suitable as a hard tissue implant ceramic material in the biomedical field, inorganic-organic composite Material enhancements, active coatings of metal biomaterials, drug carriers, ion exchangers in the field of sewage treatment, catalytic carriers in the field of catalysis and chromatographic fillers. [0003] At present, the methods for preparing nano-hydroxyapatite mainly include sol-gel method, microemulsion method, co-precipitation method and hydrothermal method. Among ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C01B25/32
Inventor 高家诚张敏陈飞宏
Owner CHONGQING UNIV
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