Preparation method of 2, 6-dichlor fluorbenzene

A technology for dichlorofluorobenzene and dichloride, which is applied to the synthesis field of organic compounds, can solve the problems of difficult control of process conditions, complicated process, low product yield, etc., and achieves easy control of process conditions, wide sources, and reduced production costs. Effect
CN101643386AInactive Publication Date: 2010-02-10ZHEJIANG UNIV
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
ZHEJIANG UNIV
Publication Date
2010-02-10
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses a preparation method of 2, 6-dichlor fluorbenzene, including that diazonium salt is made by taking 3, 5-dichlor-4-fluoroanilines as raw material and the 2, 6-dichlor fluorbenzene is obtained through diazo hydrogen replacement in the presence of reducing agent. The method concretely includes the following steps: (1) 3, 5-dichlor-4-fluorbenzene is taken as raw material and reacts with inorganic acid, so as to obtain solution containing ammonium salt; (2) the solution containing ammonium salt reacts with nitrite aqueous solution, so as to obtain solution containing diazonium salt; (3) reducing agent is dropwise added into the solution containing diazonium salt until reaction product causes starch potassium iodide paper to turn blue; (4) the reaction solution obtained by the step (3) is subject to dispensing, washing and steam distillation, so as to obtain the product 2, 6-dichlor fluorbenzene. The preparation method has the characteristics of simple technology, high yield and low cost.
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Description

technical field

[0001] The invention relates to a method for synthesizing organic compounds, in particular to a method for synthesizing 2,6-dichlorofluorobenzene (2,6-dichlorofluorobenzene). Background technique

[0002] 2,6-Dichlorofluorobenzene, whose molecular formula is C 6 h 3 Cl 2 F, its structural formula is shown in S-1, the pure product is white crystal, the melting point is 37-40°C, the boiling point is 168-169°C, it is an important fine chemical intermediate, mainly used in the synthesis of fluoroquinolones and pesticides.

[0003]

[0004] According to comprehensive literature reports, the preparation of 2,6-dichlorofluorobenzene adopts the following methods at present: 1. With 2,6-dichloroaniline as raw material, through diazotization fluorination reaction, 2,6-dichlorofluorobenzene is obtained, The yield is about 80%; 2. Using 2-fluoro-3-chloronitrobenzene as raw material, 2,6-dichlorofluorobenzene is obtained through reduction and diazotization of chloro...

Claims

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