Cydiodine buccal tablets and preparation method thereof

A technology of cydidinium iodine and mass percentage, applied in the field of cydidinium lozenges and their preparation, can solve the problems of increasing the intake of sucrose, physical harm and the like, and achieve the effects of reducing the amount of sucrose and reducing potential harm

Inactive Publication Date: 2010-03-31
北京华素制药股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For this reason, cediiodine buccal tablets with sucrose as a filler increase the intake of sucrose in patien...

Method used

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  • Cydiodine buccal tablets and preparation method thereof
  • Cydiodine buccal tablets and preparation method thereof
  • Cydiodine buccal tablets and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0052] The components and weight of cediodine buccal tablets are:

[0053] 8 g of cedi-iodine, 18 g of cedithiophene, 400 g of lactose, 4 g of magnesium stearate, and a 3% HPMC (hydroxypropyl methylcellulose) aqueous solution with a mass percent concentration.

[0054] Among them, the composition and weight of Sidi iodine are: 6.97g of iodine, 5.06g of potassium iodide, and 35g of β-cyclodextrin. The components and weight of cedibranch are: menthol 5.5g, β-cyclodextrin 55g.

[0055] The preparation method of cediodine buccal tablets:

[0056] 1) Preparation of cediiodine and cedichol: the cediiodine and cedicephalus are prepared by cyclodextrin inclusion technology, which is a saturated aqueous solution method.

[0057] 2) After uniformly mixing cediodine and lactose according to the amount of the components in an equal increment method, adding an appropriate amount of 3% HPMC aqueous solution by mass percentage to make a soft material;

[0058] 3) making the soft material ...

Embodiment 2

[0063] The components and weight of cediodine buccal tablets are:

[0064] 8 g of cedi iodine, 400 g of mannitol, 18 g of cedithiophene, 2 g of aspartame, 4 g of magnesium stearate, and the mass percentage concentration is 3% HPMC aqueous solution.

[0065] Wherein, the composition and weight of cediiodine and cediole are the same as in Example 1.

[0066] The preparation method of cediodine buccal tablets:

[0067] 1) same as the 1st step of embodiment 1;

[0068] 2) After mixing the cediodine and mannitol uniformly in an equal increment method according to the component amount, add an appropriate amount of 3% HPMC aqueous solution to make a soft material;

[0069] 3) same as the 3rd step of embodiment 1;

[0070]4) Weighing cedinail, aspartame and magnesium stearate according to the component amounts, and mixing them uniformly with the dried granules;

[0071] 5) The following steps are the same as the 5th and 6th steps of Example 1.

Embodiment 3

[0073] The components and weight of cediodine buccal tablets are:

[0074] Sidi iodine 8g, xylitol 80g, cedipol 18g, isomalt 320g, magnesium stearate 4g.

[0075] Wherein, the composition and weight of cediiodine and cediole are the same as in Example 1.

[0076] The preparation method of cediodine buccal tablets:

[0077] 1) same as the 1st step of embodiment 1;

[0078] 2) each component is weighed by amount and screened with a 60 mesh sieve;

[0079] 3) Mix the screened 60-mesh components evenly with equal increment method;

[0080] 4) The following steps are the same as the 5th and 6th steps of Example 1.

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Abstract

The invention relates to cydiodine buccal tablets and a preparation method thereof. The cydiodine buccal tablets comprise the following components in percentage by mass: 0.1 to 6 percent of cydiodine,0.5 to 5 percent of sildenafil, 0 to 2 percent of lubricant, and 84.4 to 98.5 percent of filler. The filler is one or combination of the following components: mannitol, lactose, xylitol, sorbitol, erythritol, fructose, isomalt, dextrin, microcrystalline cellulose, starch, pregelatinized starch, sodium chloride. The invention also proposes a method for preparing the buccal tablets, which comprisesthe following steps: preparing cydiodine and sildenafil; weighing the components according to proportioning rate, granulating and mixing the components; determining the content of every component inmixed medicaments and calculating the weight difference of products; and tabletting the mixed medicament. In the process of treating oral or other diseases, the cydiodine buccal tablets prepared by the method have the advantages of reducing the amount of sucrose taken in by patients and reducing harm to the patients.

Description

technical field [0001] The invention relates to a cediiodine buccal tablet and a preparation method thereof, belonging to the field of cediiodine products. Background technique [0002] Iodine has been used as a disinfectant for more than 100 years, and it has non-selective killing effects on bacteria, fungi, and viruses. Through the inclusion technology of cyclodextrin, it is made into molecular iodine-cediiodine, this kind of I 2 The physical and chemical properties of the clathrate are relatively stable, and there is no I 2 It can be made into various preparations and widely used in the treatment of mouth and throat diseases. [0003] The Institute of Toxic Drugs of the Academy of Military Medical Sciences of my country applied for the patent (Patent No.: ZL90106682.6) of "Compound Sidiiodine Buccal Tablets and Its Preparation Method" on August 16, 1990. In this patent, sucrose is used as the The filling agent makes the tablet have relatively good formability and can we...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K33/18A61K47/40A61P1/02A61P11/04
Inventor 姚文静边玢魏淑冬
Owner 北京华素制药股份有限公司
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