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Water-soluble rock salt type CoO nano flower-like magnetic particles and application thereof

A technology of magnetic particles and nanoflowers, applied in the field of nanomaterials, can solve the problems of uneven surface coating thickness, poor MRI imaging effect, complex synthesis process, etc., and achieve the effect of low price, short reaction time and simple synthesis method

Inactive Publication Date: 2012-05-30
SHANGHAI NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, most of the superparamagnetic contrast agents that have been approved for marketing and are in clinical trials are composed of a core of ferric oxide particles and a layer of dextran polymer coated on the outside, with a particle size of about 25-40 nanometers. Disadvantages such as complex process, high manufacturing cost, poor MRI imaging effect, and uneven thickness of the surface coating
CoO magnetic nanoparticles, due to their good magnetic properties, simple preparation process, and low cost, are expected to become a better magnetic resonance contrast agent, but in the current literature, for CoO nanoparticles in biological imaging There are very few reports on the application in

Method used

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  • Water-soluble rock salt type CoO nano flower-like magnetic particles and application thereof
  • Water-soluble rock salt type CoO nano flower-like magnetic particles and application thereof
  • Water-soluble rock salt type CoO nano flower-like magnetic particles and application thereof

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Experimental program
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Effect test

Embodiment 1

[0041] Weigh anhydrous CoCl 2 (0.5194g, 4mmol) was dissolved in 6ml of water, added sodium oleate (2.4355g, 8mmol), then added 8ml of absolute ethanol, 14ml of n-hexane, heated to 70 ° C, refluxed for 4h, cooled to room temperature, and then washed with distilled water 5-6 times, the oil phase was collected, and the n-hexane was removed by rotary evaporation, and finally a purple oily cobalt oleate complex was obtained.

Embodiment 2

[0043] Add octadecene (20g) and oleic acid (0.7ml, 2.3mmol) to the cobalt oleate complex synthesized in Example 1, first heat to 110°C, react for 1h to drain water, and then perform anaerobic operation; continue to heat up Reaction at 320°C for 2 hours; after the reaction is complete, cool naturally to room temperature, centrifuge, wash the precipitate with a small amount of cyclohexane and absolute ethanol, and dry it in vacuum at 15-30°C for 10-20 hours to obtain oleic acid molecules coated on the surface The rock-salt-type CoO nanoparticles, that is, the oil-soluble rock-salt-type CoO nano-flower-shaped magnetic particles (represented by CoO).

[0044] Its transmission electron microscope image is shown in figure 1 , with an average particle size of 135nm; the selected area electron diffraction pattern is shown in figure 2 , X-ray diffraction (XRD) spectrum as image 3 .

[0045] Hysteresis loop diagram as Figure 8 , is the change relationship between the magnetic ind...

Embodiment 3

[0048] To 4ml containing the CHCl of the oil-soluble rock-salt type CoO nano-flower-like magnetic particle that 10mg / ml embodiment 2 prepares 3 In the solution, add 20ml containing 0.4g (1mmol) cetyltrimethylammonium bromide (CH 3 (CH 2 ) 15 N(Br)(CH 3 ) 3 , CTAB) in aqueous solution, stirred at room temperature for 10 h, and rotary evaporated CHCl 3 solution, washed with distilled water and centrifuged to obtain water-soluble rock-salt-type CoO nano-flower magnetic particles (expressed as CoOCTAB) with positive charges on the surface.

[0049] its T 1 , T 2 weighted image Figure 12 The (a) and (b) are obtained from the test of a 0.5T magnetic resonance imager, and the specific parameters are: (1)T 1 Weighted imaging: TR / TE=1500 / 1ms, slice thickness is 0.8mm, spectral width SW=66KHz, receiver gain RG=3. (2)T 2 Weighted imaging: TR / TE=1500 / 2ms, slice thickness is 0.4mm, spectral width SW=66KHz, receiver gain RG=3. It can be seen from the figure that with the gradual...

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Abstract

The invention discloses water-soluble rock salt type CoO nano flower-like magnetic particles. A method for preparing the particles comprises the following steps of: using octadecene as a solvent and oleic acid as a surfactant to perform pyrolysis on a precursor cobalt oleate under the protection of an inert gas so as to obtain rock salt type nano flower-like CoO oil-soluble magnetic nanoparticles; and modifying surfactants with different electric charges on the surfaces of the nanoparticles by using a hydrophobic interaction of a long alkane chain so as to prepare three types of water-solublenanoparticles of which the surfaces are provided with different electric charges. The nanoparticles have water-solubility and biocompatibility, high saturation magnetic susceptibility and strong relaxation capacity, can be used inside biological cells because of the biocompatibility and can be used as a magnetic resonance imaging contract agent material. The preparation method has a short reaction time, the needed raw materials are easy to obtain and have low prices, the operational process is convenient, byproducts are nuisance-less, and an economical and practical new method for the synthesis and the preparation of nano magnetic resonance imaging contract agent materials is provided.

Description

technical field [0001] The invention belongs to the technical field of nanometer materials, and relates to a water-soluble rock-salt type CoO nanometer flower-shaped magnetic particle and an application thereof. Background technique [0002] With the development of modern medical technology, magnetic resonance imaging (magnetic resonance imaging, MRI) technology came into being. Magnetic resonance imaging is a high-tech imaging based on the performance characteristics of biological magnetic nuclei (hydrogen nuclei) in a magnetic field. In the past 20 years, with the advancement of related technologies such as magnet technology, superconducting technology, low temperature technology, electronic technology, and computer technology, MRI technology has developed rapidly. Today, it has been widely used in clinical practice and has become an indispensable member in the field of modern medical imaging. It is another new tomographic imaging method after CT, B-ultrasound and other i...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): H01F1/11C01G51/04A61K49/06
Inventor 杨仕平周宏杨红田启威李雪健
Owner SHANGHAI NORMAL UNIVERSITY