Bionic in-situ regeneration repair nano sticking patch and preparation method and application thereof

An in-situ regeneration and patch technology, applied in the field of nano-patches, can solve the problems of too short degradation time in vivo, insufficient mechanical strength, loss of tensile strength, etc., to avoid toxic side effects and enhance mechanical properties.

Active Publication Date: 2013-03-06
SUZHOU BOCHUANG TONGKANG PHARM TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are many defects in its products that affect the performance of its functions. For example, the thickness of collagen sponge or membrane products ranges from 0.5mm to 5mm, resulting in soft products and poor tissue adhesion. Tensile strength makes it inconvenient for clinical surgeons to operate. In order to obtain certain mechanical properties, cross-linking agents such as glutaraldehyde must be added. In addition to certain tissue toxicity, cross-linking agents can easily lead to calcification; animal-derived proteins These products have relatively large safety risks (such as viruses, pathogenic microorganisms, etc.) and adverse reactions such as human allergies caused by protein macromolecules; the mechanical strength of carboxymethyl cellulose and chitosan products is not enough, and the degradation time in vivo is either too short or too long. long; and the degradation of polylactic acid products produces acidic products, etc.; therefore, the development of an innovative product that overcomes the defects of existing membrane products has very important clinical application value

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Example 1. Prepare a 12 cm diameter of the petri dish, and a built -in diameter polymer material film (was washed, sterilized, and removed thermal treatment) to dry;Shelling, 0.1mol / L acetic acid, 0.2 mol / L NaCl, pH = 4) and B Li (1 mg / ml carboxymethyl cylinder shell polycan, 0.15 mol / l naCl, pH = 6); Take part of the B Li add functional polypeptides (1 × 10 -4 Mg / ml) is made into C-liquid, and the function of the function of the function of the function is: lysine-lysine-cysteine-serine-arginine-glycine-illarine-cysteine-lymine-oligateAcids-lysine; pour the above solution to the high-pressure instant spraying equipment, first spray C solution at high pressure instantaneous when the dine is high-pressure; then spray A solution at a high pressure instantaneous instantaneous spray, rinse with water with water;Rinse with water with injections, so as to spray A, B, and rinse, and repeat 800 times; then spray A solution at a high pressure instantly, rinse with water with water; ...

Embodiment 2

[0027] Example 2. Prepare a 12 cm diameter of the petri dish, and a built -in diameter polymer material film (was washed, sterilized, and removed thermal treatment) to dry;Slutin, 0.1mol / L acetic acid, 0.2 mol / L naCl, pH = 4) and B liquid (2 mg / ml of alginic acid, 0.15mol / l naCl, pH = 6) referred to as B Li; Add some B liquid to the epidermal growth factor (EGF) (0.01mg / ml) to be made into a C -liquid; pour the above solution to the high -pressure instant spraying equipment, first spray C to the high -pressure instant C in the dine, dry the film into the film into the film into the film formation, the film forms the film into a film formation into a film formation.; Then spray A solution instantaneously, rinse with water with injection; then spray B liquid at high pressure, rinse with water with water, and alternately spray A liquid, B liquid, rinse, and repeat the operation 200 times; then high -voltage instant spray A solution, useRinse with water in injection; finally spray C s...

Embodiment 3

[0028] Example 3. Prepare a 12 cm diameter of the dine, a built -in diameter polymer material film (washed and sterilized and removed thermal treatment), washed and dried in injection;, 0.1mol / L acetic acid, 0.2mol / L NaCl, pH = 3.5) and B Li (1 mg / ml hyaluronic acid, 0.15mol / l naCl, pH = 6);Put it in the high -pressure instant spraying equipment, first spray A liquid at high pressure in the dine, dry, and then spray B liquid at high pressure instantaneous instantaneous spraying, rinse with water with water, so as to alternate A liquid, B liquid, rinse, and repeat the operation 500 times; finallyThen spray A solution at a high pressure, rinse with water with water, dry, unveil the film, rinse with water with injection, and dry the finished product.

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PUM

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Abstract

The invention relates to a bionic in-situ regeneration repair nano sticking patch, which is formed by overlapping an layer A with a cationic group material and a layer B with an anionic group material sequentially, wherein the sticking patch comprises 20 to 80 percent by mass of the A layer with the cationic group material and the balance of the layer B with the anionic group material; layer A with the cationic group material comprises at least one of polysaccharide with a cationic group, protein with the cationic group or opypeptide (polypeptide) with the cationic group; layer B with the anionic group material comprises at least one of polysaccharide with an anionic group, protein with the anionic group or opypeptide (polypeptide) with the anionic group; and the sticking patch comprises not more than 10 percent by mass of added functional factors and / or functional polypeptide. The raw materials used by the invention are materials which can be degraded in vitro and have biocompatibility. The sticking patch is flexible, has good tissue adhesivity, is suitable for concave-convex surfaces of visceral organs, has strong stretching resistance and air pressure resistance, is suitable for application of sticking, sealing, leak stoppage, hemostasia, isolation, repair, adhesion prevention and artificial meninges of defect tissues and can also be used as a slowly-releasing carrier of a medicament and a nano-grade tissue engineering support material.

Description

Technical field [0001] The present invention is the field of biomedical technology, which involves a nano -supplement tablet composed of pine -ion group materials, functional factors and / or functional polypeptides, and yang ion group materials composite.And provide the preparation method of the nano -supplement, and the adhesion, closure, leakage, hemostasis, isolation, repair, repair, anti -infection, and artificial meninges of the adhesion, closure, leakage, hemostasis, restoration, and artificial meningifier in surgical surgery.Carrings and nano -level organization engineering bracket materials. Background technique [0002] In surgical surgery, it is often necessary to be closed, repaired and prevent adhesion of defects and damage tissues. Existing products include film and gel products with carboxymethyl cellulose, shell polycan, polymapilic acid, collagen and fibrin gel. TheseTo a certain extent, the product plays a positive role in the closure, repair and adhesion of the d...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L31/12A61L31/16A61L27/44A61L27/54A61K47/36A61K47/42A61M31/00A61M37/00
Inventor 吴昌琳
Owner SUZHOU BOCHUANG TONGKANG PHARM TECH CO LTD
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