Metoprolol controlled release mixed matrix tablet and preparation method thereof
The technology of matrix tablet and skeleton is applied in the preparation of metoprolol sustained-release tablets, metoprolol controlled-release mixed matrix tablet and the field of preparation thereof, and can solve the problems of hard particles, uneven distribution, high tablet hardness and the like, To achieve the effect of simple production process, smooth tableting process and low production cost
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Embodiment 1
[0035] The formula of metoprolol tartrate controlled release mixed matrix tablet is as shown in table 1:
[0036] Table 1 Metoprolol tartrate controlled-release mixed matrix tablet formula
[0037] Name of raw material
Prescription amount (mg)
percentage(%)
Metoprolol tartrate
100
13.44
Hypromellose (Methocel K100M)
298
40.05
lactose
33
4.44
Ethyl cellulose (3-15μm)
236
31.72
Polyvinylpyrrolidone (K30)
60
8.06
Sodium dodecyl sulfate
15
2.02
Magnesium stearate
8
1
95% ethanol
about 300
distilled water
about 23
[0038] Tablet weight: about 750mg
[0039] Preparation:
[0040] 1. Processing of raw and auxiliary materials: Metoprolol tartrate, pulverized, and passed through a 60-mesh sieve. After the hydroxypropyl methylcellulose K100M passes through a 60-mesh sieve, put it in a rapid stirring granulator, an...
Embodiment 2
[0050] The formula of metoprolol succinate controlled-release mixed matrix tablet is shown in Table 2:
[0051] Table 2. Metoprolol succinate controlled-release mixed matrix tablet formula
[0052] Name of raw material
Prescription amount (mg)
percentage(%)
metoprolol succinate
95
13.09
Hypromellose (Methocel K100M)
295
40.63
microcrystalline cellulose
40
5.51
Ethyl cellulose (3-15μm)
226
31.13
Polyvinylpyrrolidone (K30)
55
7.58
Sodium dodecyl sulfate
13
1.79
Magnesium stearate
10
1.3
95% ethanol
about 280
distilled water
about 20
[0053] Tablet weight: about 735mg
[0054] The preparation method is as in Example 1.
Embodiment 3
[0056] The formula of metoprolol tartrate controlled-release mixed matrix tablet is shown in Table 3:
[0057] Table 3. Metoprolol tartrate controlled-release mixed matrix tablet formula
[0058] Name of raw material
Prescription amount (mg)
percentage(%)
Metoprolol tartrate
50
10.75
Hypromellose (K15M)
168.3
36.18
pregelatinized starch
51.2
11.01
Ethyl cellulose (3-15μm)
146.5
31.50
Polyvinylpyrrolidone (K30)
36.3
7.80
Sodium dodecyl sulfate
10.23
2.20
Magnesium stearate
2.58
0.55
95% ethanol
about 177
distilled water
about 13
[0059] Tablet weight: about 465mg
[0060] Preparation method is as embodiment 1.
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