Spina gleditsiae extract hydrogel patch and preparation method thereof

A technology of saponin thorn extract and hydrogel, which is applied in the direction of drug combination, medical formula, plant raw materials, etc., can solve the problems that harmful components cannot be separated, harmful metals cannot be completely removed, and the limitation of nano-Chinese medicine, etc., to achieve anti-infective drugs Good efficacy and activity, save raw materials of traditional Chinese medicine, and simple prescription

Inactive Publication Date: 2012-01-11
GUANGDONG PHARMA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Existing traditional Chinese medicines have many problems such as inaccurate curative effect, unstable quality, excessive heavy metal and pesticide residues, unreliable safety, backward technology and dosage forms, low bioavailability, and poor timeliness.
Since the 1990s, the country has set nano-Chinese medicine as the development direction of modern Chinese medicine. Although some progress has been made, the preparation technology of nano-Chinese medicine is basically limited to the ultra-fine grinding of Chinese herbal pieces, not only can not completely extract the active ingredients in Chinese medicine. , even harmful components cannot be separated, and harmful metals cannot be completely removed, so that the practical application of nano-Chinese medicine is greatly restricted, and the development of nano-Chinese medicine is slow.

Method used

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  • Spina gleditsiae extract hydrogel patch and preparation method thereof
  • Spina gleditsiae extract hydrogel patch and preparation method thereof
  • Spina gleditsiae extract hydrogel patch and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] The preparation of embodiment 1 saponins thorn extract hydrogel plaster

[0027] 1. Preparation of Saponaria thorn extract

[0028] The preparation of saponin thorn gasification explosive solution is prepared by the reference "Preliminary study on the external antibacterial effect and components of saponin thorn gasification explosive solution" (Journal of Guangdong Pharmaceutical University, 2010, 26 (6): 579~582). Cut the raw material of saponin thorn into sections, and put it in a gasifier (name of equipment: gasification explosion extraction equipment, manufacturer: Tonghua Institute of Traditional Chinese Medicine, Jilin Province, patent name of this equipment: a special device for extracting effective parts of Chinese herbal medicine, Patent No. 01212112.6) is heated to 800°C to produce yellow gas that enters the detonation chamber, and then passes through CO detonation chamber. After automatic liquefaction, the liquid is collected (filtered or clarified after s...

Embodiment 2

[0064] Example 2 Skin irritation test of single administration in rabbits

[0065] 4 New Zealand rabbits were used for animal experiments to remove the skin and hair on the back of the rabbits with a depilatory liquid, with a range of 5cm x 5cm on the left and right sides, and kept them for 24 hours. The medicated patch and blank patch prepared in Example 1 were respectively applied to the depilatory areas on both sides, with a size of 3 cm × 3 cm, fixed with non-irritating bandages, and kept in separate cages. After 24 hours, remove the blank patch and the medicated patch, clean the skin with warm water, observe and record whether there is erythema and edema at the application site 1 hour, 24 hours, 48 ​​hours and 72 hours after removing the drug. The degree of erythema and edema is evaluated from 0 to 4 points, and the smaller the score, the lower the skin irritation.

[0066] After a single administration, the skin of the rabbits had no erythema and edema, and the total ...

Embodiment 3

[0067] Example 3 Pharmacodynamic experiment of mice infected with Staphylococcus aureus

[0068] (1) Cultivation and preparation of bacterial strains for infection: ATCC6538 Staphylococcus aureus strains were shaken and grown overnight in nutrient agar medium, and transferred to new nutrient agar medium on the second day. When the bacteria grew to the logarithmic growth phase, use Quickly wash 2 times with sterile normal saline, and then resuspend the bacteria to 1×10 9 CFUs / 100μl or 1×10 8 CFUs / 50 μl.

[0069] (2) Establishment of the mouse skin infection model: the mice were depilated on the back 24 hours before the experiment, and 0.2ml / mouse of Staphylococcus aureus was injected subcutaneously. After 24 hours, purulent infection of the back skin of the mice could be seen.

[0070] (3) Experimental grouping and administration: 40 Kunming mice, half male and half male, were randomly divided into 4 groups, 10 mice in each group. The specifics are as follows: ①medicated p...

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Abstract

The invention discloses a spina gleditsiae extract hydrogel patch and a preparation method thereof, and belongs to the technical field of pharmaceutic preparation. The spina gleditsiae extract hydrogel patch is formed by mixing a spina gleditsiae extract and a blank hydrogel substrate; the phenolic acid compound contend of the spina gleditsiae extract is 6-7 mg/ml; the blank hydrogel substrate is formed by stirring and mixing an oil phase and a water pahse, wherein the weight ratio of the oil phase and the water phase is 50-60:100; the components of the oil phase are glycerin, polyacrylic acid, dihydroxyaluminum aminoucetate, and azone; the components of the water phase are water, carboxymethylcellulose sodium, tartaric acid, EDTA-2Na, and titanium dioxide. The spina gleditsiae extract hydrogel patch of the invention has simple substrate prescription, high water content, and strong affinity, is reliable and stable, has no irritation to skin, has good anti-infection drug effect activity, allows convenient addition of various Chinese herbal medicine extracts, and is widely applicable to aspects such as surgical wounds, general wounds, skin infection, cosmetology and skin beautification, and the like.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, and in particular relates to a saponin thorn extract hydrogel sheet and a preparation method thereof. Background technique [0002] Due to the widespread use and even abuse of antibiotics, the emergence of bacterial resistance has accelerated, and the situation of anti-infection treatment is becoming more and more severe. A common example is Staphylococcus aureus, which is one of the common pathogenic bacteria in hospital infections. It can infect wounds, including wounds caused by medical operations, and further enter the human body, causing serious infectious diseases. Conventional drugs for treating infection are mainly chemical drugs. Long-term use can easily cause bacterial drug resistance, affect the curative effect, and even cause harm to the human body. Therefore, finding and developing safe and effective anti-infective drugs with low side effects has very important t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/483A61K9/70A61P1/16A61P7/02A61P35/00A61P37/02
Inventor 杨红何震宇李红枝董艳芬赵美顺黄庆
Owner GUANGDONG PHARMA UNIV
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