Azoxystrobin nano-water suspending agent and its preparation method

A technology of azoxystrobin and nano-water, which is applied in the field of azoxystrobin nano-aqueous suspension agent and its preparation, can solve the problems of high difficulty, low drug loading and adsorption rate, and high energy consumption, and achieves the effect of avoiding agglomeration

Inactive Publication Date: 2012-08-08
HENAN AGRICULTURAL UNIVERSITY +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, there are technologies for making the active ingredients of pesticides into nano-water suspensions, but there are still some defects in these current technologies: (1) Most nano-water suspensions use organic solvents during preparation, and the final nano-water suspensions It also contains organic solvents, which will pollute the environment when used, which is not conducive to environmental protection; (2) At present, most nanomaterial carriers are used to adsorb pesticides, and organic solvents are used for loading, resulting in lower drug loading and adsorption rates for pesticides. (3) There are also some nano-water suspensions that have high energy consumption, high cost and difficulty in preparation, and cannot realize industrial production, which brings difficulties to the application of nano-water suspensions

Method used

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  • Azoxystrobin nano-water suspending agent and its preparation method
  • Azoxystrobin nano-water suspending agent and its preparation method
  • Azoxystrobin nano-water suspending agent and its preparation method

Examples

Experimental program
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Effect test

Embodiment 1

[0018] Weigh 12 g of azoxystrobin original drug, add 600 mL of methanol and stir to dissolve, then add 12 g of hydrophobic and dispersible nano-silica to obtain an oil phase; add 2 g of calcium lignosulfonate and 4 g of fatty alcohol polyoxyethylene ether into 60 g of water , 5 g of ethylene glycol, and 0.05 g of sodium o-phenylphenate were stirred and dissolved to obtain a water phase, and the water phase was slowly added dropwise to the oil phase, stirring rapidly while adding the water phase; Distill under reduced pressure in a water bath to completely distill methanol out; finally add 0.2g of xanthan gum, 1g of magnesium aluminum silicate, and make up to 100g of water to shear and emulsify evenly to obtain 12% azoxystrobin nano-water suspension. The average particle size of the product was detected to be 100 nm.

Embodiment 2

[0020] Weigh 20 g of azoxystrobin original drug, add 300 mL of acetone and stir to dissolve, then add 10 g of dispersible nano-silica to obtain an oil phase; add 2 g of calcium lignosulfonate, alkylphenol formaldehyde condensate sulfonic acid to 50 g of water 0.8g of salt, 4.8g of nonylphenol polyoxyethylene ether phosphate, 5g of ethylene glycol, and 0.05g of benzoic acid were stirred and dissolved to obtain a water phase, and the water phase was slowly added dropwise to the oil phase, and stirred rapidly while adding; After the water phase is added dropwise, distill under reduced pressure in a 30°C water bath with stirring to completely distill the acetone; finally add 0.2g of xanthan gum, 1g of magnesium aluminum silicate, and make up to 100g of water to shear and emulsify evenly to obtain 20% pyrimidine Strostrobin nano-water suspension. The average particle size of the product was detected to be 165 nm.

Embodiment 3

[0022] Weigh 20 g of azoxystrobin original drug, add 300 mL of acetone and stir to dissolve, then add 30 g of dispersible nano-silicon dioxide to obtain an oil phase, add 2 g of calcium dodecylbenzenesulfonate, styrene ethyl phenol to 35 g of water 3g of oxyethylene polyoxypropylene ether, 1g of methylene bis-naphthalene sulfonate, 5g of ethylene glycol, and 0.05g of benzoic acid were stirred and dissolved to obtain a water phase, and the water phase was slowly added dropwise to the oil phase, stirring rapidly while adding After the addition of the water phase is completed, distill under reduced pressure in a water bath at 30°C under stirring to completely distill the acetone; finally add 0.2 g of xanthan gum and 1 g of magnesium aluminum silicate, make up to 100 g of water and emulsify evenly to obtain 20 % azoxystrobin nano water suspension. The average particle size of the product was detected to be 75 nm.

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Abstract

The invention relates to an azoxystrobin nano-water suspending agent, which comprise, by mass: 10-20% of azoxystrobin, 10-30% of hydrophobic dispersible nano-silica, 2-10% of a wetting dispersant, 0.2-3% of a thickening agent, 1-5% of an antifreezing agent, 0.01-0.2% of a preservative, and the balance water. The azoxystrobin nano-water suspending agent of the invention has the advantages of: small particle size, high fluidity, and enhanced penetration and conductivity within leaves. Due to enhanced surface energy, the nano-water suspending agent provided in the invention is easier to be adsorbed by plants. As wind blow and rain wash resistance are strengthened, pesticide residues flowing into water and soil can be reduced. With certain slow release effect, the azoxystrobin nano-water suspending agent in the invention can reach the purposes of improving drug effects and prolonging the duration period.

Description

technical field [0001] The invention relates to a nano-water suspension, in particular to an azoxystrobin nano-water suspension and a preparation method thereof. Background technique [0002] Nanotechnology has developed rapidly in recent years and has been widely used in materials, manufacturing and other fields, and has brought profound changes to human life. When it comes to the field of pharmacy, the nanometer size is generally defined as 1~1000nm. Nano-pharmaceutical preparations are mainly made of particles of drugs or drugs adsorbed and wrapped in carriers to make particles in the nanometer size range, and then made into different types of dosage forms based on them. Due to the unique small size effect and certain surface effect of nano drug preparations, it shows many excellent properties and new functions, which will enable the production of drugs to achieve low cost, high efficiency, automation, and large scale; The function will realize organ targeting, and has b...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A01N43/54A01N25/04A01P3/00
Inventor 宋美荣雷天乾刘德仓李红金范彩玲高飞
Owner HENAN AGRICULTURAL UNIVERSITY
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