Nucleic acid medicine loading system for targeted therapy and preparation method of nucleic acid medicine loading system

A drug-carrying system and targeted therapy technology, which is applied in the direction of pharmaceutical formulations, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., can solve problems such as lack of drugs, unstable complexes, complex organic reactions, etc. , to achieve the effect of simple and efficient preparation process, inhibition of cancer cell growth, and high drug loading
CN102716494AActive Publication Date: 2012-10-10HUNAN UNIV
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
HUNAN UNIV
Publication Date
2012-10-10

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Abstract

The invention discloses a nucleic acid medicine loading system for targeted therapy and a preparation method of the nucleic acid medicine loading system. The system is adduct consisting of DNA (deoxyribonucleic acid) aptamers as medicine carriers and targeted probes and anticancer medicine loaded onto the DNA aptamers. The targeted identification specificity, high stability and easy modification of the DNA aptamers are utilized, and the DNA aptamer-anticancer medicine adduct is prepared, so small molecule medicine is modified onto the DNA aptamers. The DNA aptamers are very stable at the solid state or low temperature liquid state (such as the temperature below 10 DEG C) and is suitable for being stored for a long time. The adduct maintains the identification specificity of the original DNA aptamers to targeted cancer cells, medicine can be conveyed to cancer cells in a targeted way and can be gradually released at the physiological temperature, the special killing and injury effect on the targeted cancer cells is generated, the side effect is reduced, and the curative effect is improved. The nucleic acid medicine loading system and the preparation method have the advantages that the preparation process is simple, economy is realized, the efficiency is high, and the preparation process is suitable for mass production and is particularly suitable for being used for preparing the targeted medication anticancer medicine.
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Description

technical field

[0001] The invention belongs to the technical field of targeted drug delivery systems, and relates to targeted drug delivery for cancer treatment, in particular to a nucleic acid aptamer-based carrier and anticancer drug adduct as well as its preparation and application. Background technique

[0002] Chemotherapy is currently the most widely used cancer therapy in clinical practice. However, the nonspecificity of traditional chemotherapeutic drugs causes them to induce cytotoxicity and inhibit cell expansion not only to rapidly growing cancer cells but also to rapidly growing normal, healthy cells, including bone marrow hematopoietic cells, hair follicles, oral , digestive tract, reproductive system cells, etc. This toxicity to healthy cells leads to obvious side effects of chemotherapy, and thus only a very limited maximum tolerated drug dose can be used clinically. In addition, the bioavailability of traditional small molecule chemotherapy drugs is very l...

Claims

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