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Method of preparing magnesium-doped hydroxyapatite/titania active film on surface of medical titanium alloy

A technology of magnesium hydroxyapatite and titanium dioxide, which is applied in surface reaction electrolytic coating, coating, medical science and other directions, can solve the problems of the influence of the purity of the film layer, the low bonding force between the film layer and the substrate, and easy to peel off. Achieving the effects of good biological activity and cell compatibility, dense structure and uniform film thickness

Active Publication Date: 2012-10-24
HUAIYIN INSTITUTE OF TECHNOLOGY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the bonding force between the film layer and the substrate obtained by these processes is not high, and it is easy to peel off
In addition, the magnesium-containing β-TCP phase and CO 3 2- , the purity of the film layer is affected

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Embodiment 1: Preparation of Mg-HA / TiO on the Surface of Medical Pure Titanium 2 Active film layer:

[0020] (1) Ca(NO 3 ) 2 4H 2 O, Mg(NO 3 ) 2 ·6H 2 O and (NH 4 ) 2 HPO 4 Prepare the main electrolyte according to 8g / L, 0.2g / L, and 2.5g / L respectively, add 0.2g / L sodium hydroxide and 0.3g / L sodium glycerophosphate, and adjust the pH value of the solution to 10 with ammonia water and acetic acid;

[0021] (2) The medical pure titanium after grinding and polishing is used as the anode, and the stainless steel electrolytic cell is used as the cathode. The micro-arc oxidation is carried out under the condition of constant voltage mode by using a unidirectional DC pulse power supply. The process parameters are: the forward loading voltage is 300V, The frequency is 1800Hz, the duty cycle is 30%, and the oxidation time is 10min;

[0022] (3) The medical pure titanium material with a composite film layer was washed sequentially with deionized water and absolute etha...

Embodiment 2

[0023] Example 2 : Preparation of Mg-HA / TiO on the surface of medical NiTi alloy 2 active film layer

[0024] (1) Ca(NO 3 ) 2 4H 2 O, Mg(NO 3 ) 2 ·6H 2 O, (NH 4 ) 2 HPO 4 Prepare the main electrolyte according to 9g / L, 0.5g / L, and 3g / L, and add potassium hydroxide 0.1g / L and sodium glycerophosphate 0.5g / L, and adjust the pH value of the solution to 11 with ammonia water and acetic acid;

[0025] (2) The polished and polished medical NiTi alloy is used as the anode, the stainless steel electrolytic cell is used as the cathode, and the micro-arc oxidation is carried out under constant voltage mode using a unidirectional DC pulse power supply. The process parameters are: the forward loading voltage is 375V, The frequency is 1200Hz, the duty cycle is 40%, and the oxidation time is 15min;

[0026] (3) The medical NiTi alloy material with a composite film layer was washed with deionized water and absolute ethanol in sequence, dried, and packaged to obtain Mg-HA / TiO with ...

Embodiment 3

[0027] Embodiment 3: Preparation of Mg-HA / TiO on the Surface of Medical TC4 Alloy 2 active film layer

[0028] (1) Ca(NO 3 ) 2 4H 2 O, Mg(NO 3 ) 2 ·6H 2 O, (NH 4 ) 2 HPO 4 Prepare the main electrolyte according to 9g / L, 1g / L, and 3g / L, add 0.2g / L sodium hydroxide and 0.6g / L sodium glycerophosphate, and adjust the pH value of the solution to 11 with ammonia water and acetic acid;

[0029](2) The medical TC4 alloy after grinding and polishing is used as the anode, and the stainless steel electrolytic cell is used as the cathode, and the micro-arc oxidation is carried out under the condition of constant voltage mode by using a unidirectional DC pulse power supply. The process parameters are: the forward loading voltage is 450V, The frequency is 900Hz, the duty cycle is 50%, and the oxidation time is 20min;

[0030] (3) The medical TC4 alloy material with a composite film layer was washed sequentially with deionized water and absolute ethanol, dried, and packaged to ob...

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PUM

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Abstract

The invention discloses a method of preparing a magnesium-doped hydroxyapatite / titania active film on the surface of medical titanium alloy. According to the invention, the technology of microarc oxidation is used for synthesis of the magnesium-doped hydroxyapatite / titania active film on the surface of titanium alloy in phosphate electrolyte containing magnesium ions and calcium ions. The film prepared by using the preparation method provided by the invention has a porous structure, high binding strength with a titanium alloy substrate and good biological activity and cellular affinity.

Description

technical field [0001] The invention belongs to a method for preparing a bioactive film layer on the surface of a medical titanium alloy, and specifically refers to in-situ growth of magnesium-doped hydroxyapatite / titanium dioxide (Mg-HA / TiO2) on the surface of a medical titanium alloy. 2 ) method of bioactive composite film layer. Background technique [0002] Titanium and titanium alloys are widely used as biologically inert materials for implantation due to their light weight, low elastic modulus, high corrosion resistance and good biocompatibility. However, due to the different components of bone, it is only a mechanically embedded osseointegration with the bone, rather than a chemical osseointegration. The phase composition of the surface of the material, so that it has excellent biological activity, is a long-term problem in the clinical application of medical titanium alloys in human implants. [0003] The chemical composition of bioceramic hydroxyapatite (HA) is si...

Claims

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Application Information

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IPC IPC(8): C25D11/26A61L27/32A61L27/06A61L31/08A61L31/02
Inventor 丁红燕周广宏张娜章跃刘爱辉朱雨富
Owner HUAIYIN INSTITUTE OF TECHNOLOGY
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