Method of preparing magnesium-doped hydroxyapatite/titania active film on surface of medical titanium alloy

A technology of magnesium hydroxyapatite and titanium dioxide, which is applied in surface reaction electrolytic coating, coating, medical science and other directions, can solve the problems of the influence of the purity of the film layer, the low bonding force between the film layer and the substrate, and easy to peel off. Achieving the effects of good biological activity and cell compatibility, dense structure and uniform film thickness

Active Publication Date: 2012-10-24
HUAIYIN INSTITUTE OF TECHNOLOGY
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  • Abstract
  • Description
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AI Technical Summary

Problems solved by technology

However, the bonding force between the film layer and the substrate obtained by these processes is not high, and it is e

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0019] Example 1: Preparation of Mg-HA / TiO on the surface of medical pure titanium 2 Active film:

[0020] (1) Use deionized water to remove Ca(NO 3 ) 2 ·4H 2 O, Mg(NO 3 ) 2 ·6H 2 O and (NH 4 ) 2 HPO 4 Prepare the main electrolyte at 8g / L, 0.2g / L, and 2.5g / L, add 0.2g / L sodium hydroxide and 0.3g / L sodium glycerophosphate, and adjust the pH value of the solution to 10 with ammonia and acetic acid;

[0021] (2) After grinding and polishing, medical pure titanium is used as the anode, and the stainless steel electrolytic cell is used as the cathode. The unidirectional DC pulse power supply is used for micro-arc oxidation under constant voltage mode. The process parameters are: the forward loading voltage is 300V, The frequency is 1800Hz, the duty cycle is 30%, and the oxidation time is 10min;

[0022] (3) The medical pure titanium material on which the composite film is grown is washed, dried, and packaged in deionized water and absolute ethanol in order to obtain Mg-HA / TiO with good bi...

Example Embodiment

[0023] Example 2 :Preparation of Mg-HA / TiO on the surface of medical NiTi alloy 2 Active film

[0024] (1) Use deionized water to remove Ca(NO 3 ) 2 ·4H 2 O, Mg(NO 3 ) 2 ·6H 2 O, (NH 4 ) 2 HPO 4 Configure the main electrolyte according to 9g / L, 0.5g / L, and 3g / L, add potassium hydroxide 0.1g / L and sodium glycerophosphate 0.5g / L, and adjust the pH of the solution to 11 with ammonia and acetic acid;

[0025] (2) After grinding and polishing, the medical NiTi alloy is used as the anode, and the stainless steel electrolytic cell is used as the cathode. The unidirectional DC pulse power supply is used for micro-arc oxidation in the constant voltage mode. The process parameters are: the forward loading voltage is 375V, The frequency is 1200Hz, the duty cycle is 40%, and the oxidation time is 15min;

[0026] (3) The medical NiTi alloy material on which the composite film is grown is washed, dried, and packaged in deionized water and absolute ethanol to obtain Mg-HA / TiO with good biological ...

Example Embodiment

[0027] Example 3: Preparation of Mg-HA / TiO on the surface of medical TC4 alloy 2 Active film

[0028] (1) Use deionized water to remove Ca(NO 3 ) 2 ·4H 2 O, Mg(NO 3 ) 2 ·6H 2 O, (NH 4 ) 2 HPO 4 Configure the main electrolyte according to 9g / L, 1g / L, and 3g / L, add 0.2g / L sodium hydroxide and 0.6g / L sodium glycerophosphate, and adjust the pH of the solution to 11 with ammonia and acetic acid;

[0029] (2) After grinding and polishing, the medical TC4 alloy is used as the anode, and the stainless steel electrolytic cell is used as the cathode. The unidirectional DC pulse power supply is used for micro-arc oxidation under constant voltage mode. The process parameters are: the forward loading voltage is 450V, The frequency is 900Hz, the duty cycle is 50%, and the oxidation time is 20min;

[0030] (3) The medical TC4 alloy material on which the composite film is grown is washed, dried, and packaged in deionized water and absolute ethanol to obtain Mg-HA / TiO with good bioactivity and bioco...

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Abstract

The invention discloses a method of preparing a magnesium-doped hydroxyapatite/titania active film on the surface of medical titanium alloy. According to the invention, the technology of microarc oxidation is used for synthesis of the magnesium-doped hydroxyapatite/titania active film on the surface of titanium alloy in phosphate electrolyte containing magnesium ions and calcium ions. The film prepared by using the preparation method provided by the invention has a porous structure, high binding strength with a titanium alloy substrate and good biological activity and cellular affinity.

Description

technical field [0001] The invention belongs to a method for preparing a bioactive film layer on the surface of a medical titanium alloy, and specifically refers to in-situ growth of magnesium-doped hydroxyapatite / titanium dioxide (Mg-HA / TiO2) on the surface of a medical titanium alloy. 2 ) method of bioactive composite film layer. Background technique [0002] Titanium and titanium alloys are widely used as biologically inert materials for implantation due to their light weight, low elastic modulus, high corrosion resistance and good biocompatibility. However, due to the different components of bone, it is only a mechanically embedded osseointegration with the bone, rather than a chemical osseointegration. The phase composition of the surface of the material, so that it has excellent biological activity, is a long-term problem in the clinical application of medical titanium alloys in human implants. [0003] The chemical composition of bioceramic hydroxyapatite (HA) is si...

Claims

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Application Information

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IPC IPC(8): C25D11/26A61L27/32A61L27/06A61L31/08A61L31/02
Inventor 丁红燕周广宏张娜章跃刘爱辉朱雨富
Owner HUAIYIN INSTITUTE OF TECHNOLOGY
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