Medical porous metal material for replacing weight-bearing bone tissues and preparation method of medical porous metal material

A porous metal and bone tissue technology, applied in tissue regeneration, medical science, prosthesis, etc., can solve the problems of insufficient purity of finished products, carbon skeleton residues, and reduced biological safety, and achieve high qualified rate of finished products and uniform distribution of pores , Improve the effect of mechanical properties

Active Publication Date: 2012-11-28
CHONGQING RUNZE PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the limitations of its preparation method, the purity of the obtained finished product is not enough, and there are carbon skeleton residues, resulting in a decrease in biological safety

Method used

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  • Medical porous metal material for replacing weight-bearing bone tissues and preparation method of medical porous metal material
  • Medical porous metal material for replacing weight-bearing bone tissues and preparation method of medical porous metal material
  • Medical porous metal material for replacing weight-bearing bone tissues and preparation method of medical porous metal material

Examples

Experimental program
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Effect test

Embodiment 1

[0031] Embodiment 1: Weigh zinc stearate, average particle diameter is less than 43 micron oxygen content is less than 0.1% tantalum powder and hydrogen peroxide mix uniformly, wherein zinc stearate accounts for 11%, hydrogen peroxide accounts for 18%, tantalum powder accounts for 71%, All are calculated by volume percentage. Compression molding: Add the above mixed powder into an injection molding machine and press it into a polyurethane foam (pore diameter 0.48-0.89mm, density 0.015g / cm2) at 82Mpa 3 ~0.035g / cm 3 , hardness greater than 50°) in molding. Degreasing treatment: vacuum degree 10 -4 Pa, from room temperature to 400°C at a heating rate of 2.0°C / min, and hold for 320 minutes; then raise the temperature from 400°C to 700°C at a heating rate of 0.5°C / min, and hold for 350 minutes. Vacuum sintering: sintering in a vacuum furnace, the sintering temperature is 2000°C, the heat preservation is 2 hours, and the vacuum degree is 10 -4 Pa, the sintering process is filled...

Embodiment 2

[0033] Embodiment 2: Weigh stearic acid, tantalum powder and ammonium bicarbonate with an average particle size less than 43 microns and an oxygen content of less than 0.1% and mix evenly, wherein stearic acid accounts for 7%, ammonium bicarbonate accounts for 25%, and tantalum powder accounts for 68% %, all in volume percentage. Compression molding: Add the above mixed powder into an injection molding machine and press it into a polyurethane foam (pore diameter 0.48-0.89mm, density 0.015g / cm2) at 87Mpa 3 ~0.035g / cm 3 , hardness greater than 50°) in molding. Degreasing treatment: vacuum degree 10 -4 Pa, from room temperature to 400°C at a heating rate of 2°C / min, and hold for 300min. Vacuum sintering: sintering in a vacuum furnace, the sintering temperature is 2100°C, the heat preservation is 4 hours, and the vacuum degree is 10 -4 Pa, the sintering process is filled with argon gas protection, the dust and dirt on the surface are removed after the product is taken out, and...

Embodiment 3

[0035] Embodiment 3: Weigh styrene-butadiene rubber, tantalum powder with an average particle diameter of less than 43 microns and an oxygen content of less than 0.1%, and mix evenly with hydrogen peroxide, wherein styrene-butadiene rubber accounts for 12%, hydrogen peroxide accounts for 15%, and tantalum powder accounts for 73%, all with Volume percentage meter. Pressure molding: Add the above mixed powder into an injection molding machine and press it into a polyurethane foam (pore diameter 0.48-0.89mm, density 0.015g / cm2) at 52Mpa 3 ~0.035g / cm 3 , hardness greater than 50°) in molding. Degreasing treatment: vacuum degree 10 -4 Pa, from room temperature to 400°C at a heating rate of 0.3°C / min, and hold for 360min. Vacuum sintering: sintering in a vacuum furnace, the sintering temperature is 2200°C, the heat preservation is 2.5 hours, and the vacuum degree is 10 -3 Pa, the sintering process is filled with argon protection, cooled out of the furnace, dust and dirt on the p...

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Abstract

The invention discloses a medical porous metal material for replacing weight-bearing bone tissues and a preparation method of the medical porous metal material. The preparation method of the medical porous metal material comprises the following steps of: mixing tantalum powder with a pore creating material and a forming agent, and then pressing the mixed powder in an organic foam; performing forming, degreasing, sintering, cooling and heat processing to prepare the medical porous metal material; the pressure adopted in the process of press forming is 50-100 MPa, the temperature is gradually raised to 400-800 DEG C at a speed of 0.3-2 DEG C per minute in the degreasing process, argon is introduced in to form protective atmosphere, and the temperature is preserved for 300-360 minutes; the pore creating material is ammonium hydrogen carbonate or hydrogen peroxide, the forming agent is one or more of stearic acid, zinc stearate, wax and synthetic resin, and the formed medical porous tantalum material has the pore diameter of 100-500 microns, the porosity degree of 55-65%, the elastic modulus of 3.8-4.2 Gpa and the elongation percentage of 9.3-10.7%. Through the preparation method of porous tantalum disclosed by the invention, the final content of impurity in the porous tantalum material is very low, and simultaneously the contradiction that the medical porous tantalum material for replacing a weight-bearing site requires larger porosity and also requires good mechanical property is efficiently solved.

Description

technical field [0001] The invention relates to a porous medical metal implant material and a preparation method thereof, in particular to a medical implant porous metal material for replacing bone tissue in a load-bearing part and a preparation method thereof. Background technique [0002] Porous medical metal implant materials have important and special uses in the treatment of bone tissue trauma and femoral tissue necrosis. Common materials of this type include porous metal stainless steel and porous metal titanium. As a porous implant material used in the treatment of bone tissue trauma and femoral tissue necrosis, its porosity should reach 30-80%, and the pores should be all connected and evenly distributed, or it should be consistent with the growth of human bone tissue as needed. , and reduce the weight of the material itself, so that it is suitable for human implantation. [0003] The refractory metal tantalum / niobium, because of its excellent biocompatibility, its ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C22C1/08C22C27/02A61L27/04A61L27/56
CPCB22F3/1137B22F3/1125A61L2430/02A61L27/04A61L27/56A61L27/047C22C1/08C22C27/02B22F3/1021
Inventor 叶雷
Owner CHONGQING RUNZE PHARM CO LTD
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