Method for preparing medical porous metal material substituting for load-bearing bone tissue

A porous metal and bone tissue technology, applied in medical science, prosthesis, etc., can solve the problems of reduced biological safety, insufficient purity of finished products, carbon skeleton residues, etc., and achieve improved mechanical properties, high qualified rate of finished products, and pore distribution. uniform effect

Active Publication Date: 2014-04-23
CHONGQING RUNZE PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the limitations of its preparation method, the purity of the obtained finished product is not enough, and there are carbon skeleton residues, resulting in a decrease in biological safety

Method used

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  • Method for preparing medical porous metal material substituting for load-bearing bone tissue
  • Method for preparing medical porous metal material substituting for load-bearing bone tissue
  • Method for preparing medical porous metal material substituting for load-bearing bone tissue

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Example 1: Weigh zinc stearate, tantalum powder with an average particle size less than 43 microns and oxygen content less than 0.1% and hydrogen peroxide and mix evenly, wherein zinc stearate accounts for 11%, hydrogen peroxide accounts for 18%, and tantalum powder accounts for 71%. All are calculated by volume percentage. Pressure molding: Add the above mixed powder into an injection molding machine and press it into a polyurethane foam (pore diameter 0.48-0.89mm, density 0.015g / cm2) at 80Mpa 3 ~0.035g / cm 3 , the hardness is greater than 50°). Degreasing treatment: vacuum degree 10 -4 Pa, from room temperature to 400°C at a heating rate of 1.3°C / min and hold for 324 minutes; then at a heating rate of 0.7°C / min from 400°C to 650°C for a holding time of 340 minutes. Vacuum sintering: sintering in a vacuum furnace, the sintering temperature is 2000°C, the heat preservation is 2 hours, and the vacuum degree is 10 -4 Pa, fill with argon for protection during sintering,...

Embodiment 2

[0025] Embodiment 2: Weigh styrene-butadiene rubber, tantalum powder with an average particle size of less than 43 microns and an oxygen content of less than 0.1%, and ammonium bicarbonate and mix them uniformly to form a mixed powder, wherein styrene-butadiene rubber accounts for 11.5%, ammonium bicarbonate accounts for 17%, tantalum Powder accounted for 71.5%, all in volume percentage. Pressure molding: Add the above mixed powder into an injection molding machine and press it into a polyurethane foam (pore diameter 0.48-0.89mm, density 0.015g / cm2) at 64Mpa 3 ~0.035g / cm 3 , the hardness is greater than 50°). Degreasing treatment: vacuum degree 10 -4 Pa, from room temperature to 700°C at a heating rate of 1.2°C / min, and hold for 332min. Vacuum sintering: sintering in a vacuum furnace, the sintering temperature is 2100°C, the heat preservation is 4 hours, and the vacuum degree is 10 -4 Pa, fill with argon for protection during sintering, remove dust and dirt on the surface ...

Embodiment 3

[0027] Embodiment 3: Weigh paraffin wax, tantalum powder with an average particle size of less than 43 microns and an oxygen content of less than 0.1% and mix evenly with hydrogen peroxide, wherein paraffin wax accounts for 7%, hydrogen peroxide accounts for 15%, and tantalum powder accounts for 78%, all in volume percentage count. Pressure molding: Add the above mixed powder into an injection molding machine and press it into a polyurethane foam (pore diameter 0.48-0.89mm, density 0.015g / cm2) at 52Mpa 3 ~0.035g / cm 3 , the hardness is greater than 50°). Degreasing treatment: vacuum degree 10 -3 Pa, from room temperature to 800°C at a heating rate of 2°C / min, and hold for 300min. Vacuum sintering: sintering in a vacuum furnace, the sintering temperature is 2200°C, the heat preservation is 2.5 hours, and the vacuum degree is 10 -3 Pa, fill the sintering process with argon protection, cool out of the furnace, remove dust and dirt on the surface of the product, and then perfor...

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Abstract

The invention relates to a preparation method for preparing a medical porous metal material substituting for a load-bearing bone tissue. The preparation method comprises the steps of mixing tantalum powder, a pore-forming agent and a forming agent, and further pressing mixed powder into an organic foam body for forming, degreasing, sintering, cooling and performing heat treatment, wherein the press-forming pressure is 50-100Mpa, in the degreasing process, heating is gradually performed to 400-800 DEG C at the rate of 0.3 DEG C / min-2 DEG C / min, argon gas is introduced to constitute a protective atmosphere and heat preservation is performed for 300min-360min, the pore-forming agent is ammonium hydrogen carbonate or hydrogen peroxide, and the forming agent is one or more of stearic acid, zinc stearate, paraffin wax and synthetic resin; heating to 800-900 DEG C at the rate of 10-20 DEG C / min under 10<-4>Pa-10<-3>Pa, performing heat preservation for 240-480min, further cooling to 400 DEG C at the rate of 2-5 DEG C / min, performing heat preservation for 120-300min, and then cooling to room temperature along with a furnace. The test proves that the impurity content is lower than 0.2%, the density achieves 6.67-8.34g / cm<3>, the porosity achieves 50-60%, the pore diameter achieves 150-450mu m, the elastic modulus can achieve 4.5-6.0Gpa, and the bending strength can achieve 100-120Mpa.

Description

[0001] The application of the present invention is a divisional application with the application number 201110300386.4, the application date was September 29, 2011, and the title of the invention is "A Method for Preparing a Medical Porous Metal Material Substituting Load-bearing Bone Tissue". technical field [0002] The invention relates to a preparation method of a porous medical metal implant material, in particular to a preparation method of a porous medical implant metal material suitable for replacing the bone tissue of a load-bearing part. Background technique [0003] Porous medical metal implant materials have important and special uses in the treatment of bone tissue trauma and femoral tissue necrosis. Common materials of this type include porous metal stainless steel and porous metal titanium. As a porous implant material used in the treatment of bone tissue trauma and femoral tissue necrosis, its porosity should reach 30-80%, and the pores should be all connected...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C22C1/08C22C27/02A61L27/04A61L27/56
Inventor 叶雷
Owner CHONGQING RUNZE PHARM CO LTD
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