Method for preparing pyrogallol and phloroglucinol

Abstract

The invention belongs to the field of marine chemical industry medicine intermediates, and particularly relates to a method for preparing pyrogallol and phloroglucinol, wherein the preparation route that trimethoxybenzaldehyde is subjected to catalysis decarbonylation under a hydrogen atmosphere is adopted, the modified raney nickel is adopted as a catalyst to carry out a catalysis decarbonylation reaction in a solvent, the modified raney nickel is subjected to bulk phase and surface modification based on the conventional raney nickel preparation method, the modified component is one or a plurality of materials selected from Mn, Fe, Cr, Mo, Ti and W, and the modified component content (wt) is 0.5-10 wt%. The method has characteristics of environmental protection, easy operation, wide raw material source, short reaction step, simple catalyst preparation and capability of being repeatedly applied multiple times, and is suitable for industrialization.

Description

technical field [0001] The invention belongs to the field of marine chemical pharmaceutical intermediates, and in particular relates to a method for preparing pyrogallol and pyrogallol. Background technique [0002] The method of removing functional groups of organic molecules is extremely important in chemical synthesis, especially in the synthesis of natural products. For a long time, many people engaged in chemical catalysis and organic synthesis have been working on the decarbonylation of aldehyde groups Research in this area, but they are only limited to the selection of noble metal (such as ruthenium, iridium, rhodium, etc.) .Ed.2012,51,8607-8610; A General and Convenient Method for the Rhodium-Catalyzed Decarbonylation of Aldehydes.Adv.Synth.Catal.2006,348,2148-2154, etc.), while British Mark A.Keane used Ni / SiO 2 The hydrogenolysis (decarbonylation) of benzaldehyde to benzene needs to be above 200°C, and the hydrogenolysis (decarbonylation) of methylbenzaldehyde ...

AI Technical Summary

Problems solved by technology

[0011] Trinitrotoluene (TNT) method is obtained by using trinitrotoluene as raw material through sodium dichromate oxidation (oxidation of methyl to carboxyl), high temperature decarboxylation, nitro reduction, diazotization, and hydrolysis, but due to trinitrotoluene Toluene (TNT) is an explosive, not easy to buy, and has the disadvantages of heavy metal chromium pollution and long steps

[0012] Disadvantages of the prior art: the preparation of pyrogallol by gallic acid is obtained by extracting gallic acid from the plant Galla, the source is scarce, the price is expensive, the market fluctuates greatly, and it also damages the environment, while the reaction temperature is high and the energy consumption is large;

[0013] The aniline method has a long route for the preparation of pyroglucinol, many influencing factors, insufficient production stability, and a large amount of copper sludge will be produced at the same time, causing great pollution

[0014] Trinitrotoluene (TNT) method prepares p-(homo)glucinol, because trinitrotoluene (TNT) is an explosive, it is not easy to buy, and there are heavy metal chromium pollution and long steps.

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