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A preparation method of traditional Chinese medicine microecological preparation for preventing and treating duck plague

A technology of traditional Chinese medicine microecology and duck plague, applied in pharmaceutical formulations, medical preparations containing active ingredients, antiviral agents, etc., can solve the problems of immune failure, single treatment methods, and no reports, and increase the beneficial flora. Quantity, improve immune function, no toxic side effects

Active Publication Date: 2016-06-29
广州和普生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At this stage, there is no effective treatment for the disease. The main prevention methods are vaccination and strengthening feeding management. The treatment method is single and there is a hidden danger of immune failure.
[0003] At present, vaccination is mainly used to prevent the occurrence of the disease, which has basically controlled the epidemic of typical duck plague, but virus mutation, improper use and storage of vaccine, malnutrition, other Factors such as the interference of the disease on the production of antibodies will cause immune failure, resulting in the frequent occurrence of atypical duck plague
Drugs for the treatment of duck plague are mainly antiviral amantadine, ribavirin and egg yolk antibody. Animal experiments have shown that both drugs have teratogenic effects, and amantadine can also induce drug-resistant strains. Long-term application Make the virus resistant to drugs and affect the efficacy
[0004]Although the traditional Chinese veterinary medicine preparations Shuanghuanglian, Astragalus polysaccharide, and Qingkailing have become one of the main methods for veterinary clinical treatment of livestock and poultry antiviral diseases, in the clinical It plays an important role in epidemic prevention, but these drugs have not shown satisfactory clinical effects on many common clinical viral diseases. Therefore, continuing to develop effective clinical drugs is still one of the main tasks of veterinary workers
[0005] and the traditional Chinese medicine micro-ecological preparation prepared by fermenting Chinese medicine and microorganism together, there is no report in the prior art

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] A preparation method of a traditional Chinese medicine microecological preparation for preventing and treating duck plague, comprising the following steps:

[0021] Weigh the following Chinese herbal medicines by weight (Kg): 60 honeysuckle, 60 cassia twigs, 60 isatidis, 40 Guoluhuang, 40 Qingdai, 40 Huanglian, 30 Astragalus, 30 Gynostemma, 20 licorice.

[0022] Preparation of fermented liquid: add 6 times the amount of water of the total weight of Chinese herbal medicine, soak for 30 minutes, boil with strong fire, keep warm for 30 minutes with slow fire, cool and filter with twelve layers of gauze; Filter through two layers of gauze, and combine the two filtrates. Add 20Kg of white sugar to 100Kg of filtrate as a unit, boil for 5 minutes, cool to room temperature, inoculate 5Kg of Bacillus subtilis, Lactobacillus and Zygomyces Bayer yeast preparations, and ferment in a sterile fermentation room. Ferment until pH 5.5.

[0023] The obtained fermented liquid is diluted...

Embodiment 2

[0025] A preparation method of a traditional Chinese medicine microecological preparation for preventing and treating duck plague, comprising the following steps:

[0026] Weigh the following Chinese herbal medicines by weight (Kg): Honeysuckle 80, Guizhi 80, Banlangen 80, Guoluhuang 60, Qingdai 60, Coptidis 60, Astragalus 40, Gynostemma 40, Licorice 30. Preparation of fermentation broth: add 8 times the amount of water of the total weight of Chinese herbal medicine, soak for 60 minutes, boil with strong fire, keep warm for 60 minutes with slow fire, cool and filter with twelve layers of gauze; Filter through two layers of gauze, and combine the two filtrates. Add 25Kg of white sugar to 100Kg of filtrate as a unit, boil for 5-10min, cool to room temperature, inoculate 10Kg of Bacillus subtilis, Lactobacillus and Zygomyces Bayer yeast preparations, and ferment in a sterile fermentation room. Ferment until pH 6.0.

[0027] The obtained fermented liquid is diluted 3 to 8 times ...

Embodiment 3

[0029] Clinical trial example: On May 15, 2013, 5,000 35-day-old meat ducks raised by a professional duck farmer in Huaibei District, Anhui Province developed the disease. Clinical symptoms: eyelid edema, tearing, numbness of both feet, green loose stools, and elevated body temperature , listlessness, bowing the head and shrinking the neck, loss of appetite, necrotic inflammation of the esophagus, vascular injury, serosa and viscera with hemorrhagic spots were seen in the necropsy, and the clinical diagnosis was duck plague. The number of diseased ducks was 957, and the diseased ducks were isolated and raised, then diluted 3 to 5 times with the probiotics described in Example 2, and continuously gave the ducks to drink for 7 days. After 2 hours of medication, the mental state of the diseased ducks was obviously improved. Days later, 288 ducks died, and the remaining sick ducks were basically recovered, with a cure rate of 69.90%. For ducks that did not show clinical symptoms, ...

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PUM

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Abstract

The invention discloses a preparation method of a microecological preparation of traditional Chinese medicines for preventing and treating duck plague. The microecological preparation is prepared by the following process: adding water to honeysuckle, cassia twig, radix isatidis, lysimachia christinae, indigo naturalis, coptis chinensis, astragalus membranaceus, gynostemma pentaphyllum and radix glycyrrhizae, heating by a high fire till boiling; carrying out heat preservation for 30-60 minutes by using a slow fire, cooling and filtering; and collecting filtrate; adding white sugar, heating till boiling, cooling to normal temperature, inoculating with bacillus subtilis, lactic acid bacillus and bayer joint yeast, and fermenting for 3-7d, so as to obtain the microecological preparation, wherein the obtained microecological preparation is directly drunk by ducks after being diluted according to the ratio. The microecological preparation of the traditional Chinese medicines has the efficacies of resisting viruses, inducing the generation of interferon, increasing beneficial bacteria inside intestinal tracts, improving the immune function, enhancing the disease resistance of the duck bodies, and the like, and is free of toxic and side effects. The microecological preparation is simple in preparation method, convenient to use, free of residues, and high in live bacteria content, and the effective components of the fermented traditional Chinese medicines are multiplied. Therefore, the preparation method meets the requirements of large-scale industrial production and has a good market prospect.

Description

technical field [0001] The invention belongs to the technical field of veterinary drug microecological preparations, and in particular relates to a preparation method of a natural green traditional Chinese medicine microecological preparation for preventing duck plague. Background technique [0002] Duck plague is commonly known as big head plague, also known as duck viral enteritis. The pathogen is Herpesviridae. It is an acute and highly contagious infectious disease common in ducks, geese, swans and other birds of the order Anseridae. It is a serious hazard to the waterfowl farming industry worldwide. one of the diseases. The main clinical manifestations are swollen head, tearing, numbness of both feet, green loose feces, elevated body temperature, pseudomembranous necrotic inflammation of the esophagus, vascular injury, cloacal congestion, edema, and necrosis. The disease was first discovered in the Netherlands in 1923 , my country first broke out in 1957. The disease c...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/73A61K36/72A61K36/718A61P31/22A61K35/742A61K35/747
CPCY02A50/30
Inventor 郭庆阮武营王伟杰杨涛杜海燕韩俊伟黄岩邹小娟赵智灿王海涛
Owner 广州和普生物科技有限公司