Abscisic acid receptor stimulant raw drug and preparation method thereof

An abscisic acid receptor and agonist technology, applied in the preparation of sulfonic acid, chemical instruments and methods, preparation of organic compounds, etc., can solve the problem of high production cost, achieve the effects of low cost, high activity, and improved adaptability

Inactive Publication Date: 2015-01-14
上海绿盎生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the optical configuration of natural abscisic acid in plants is only +/-cis and trans-ABA, and the production cost of traditional chemical synthesis is high. Due to the high price and th

Method used

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  • Abscisic acid receptor stimulant raw drug and preparation method thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] An original drug of an abscisic acid receptor agonist, the raw materials in molar parts include: 1 part of quinolinone, 4.5 parts of sodium hydride, 5 parts of iodopropane, 40 parts of fuming nitric acid, 1.5 parts of hydrochloric acid, 4.5 parts of iron powder, 1-2 parts, 1.2 parts of thiourea, 1.2 parts of acid-binding agent potassium carbonate, 5 parts of sodium perchlorate, 6 parts of concentrated hydrochloric acid, 1.4 parts of N,N-diisopropylethylamine.

[0041] The preparation method of the former medicine of described abscisic acid receptor agonist comprises the steps:

[0042] (1) Weighing raw materials: Weighing each raw material according to mole fraction;

[0043](2) Preparation of N-propyl quinolinone: A. Add quinolinone into the organic solvent N,N-dimethylformamide, stir at -6°C for 0.5h; B. Separate under argon protection environment Add sodium hydride in batches as a catalyst, and stir for 0.5 hours after the addition; C. Add halopropane dropwise into...

Embodiment 2

[0057] An original drug of an abscisic acid receptor agonist, the raw materials in molar parts include: 1.5 parts of quinolinone, 5 parts of sodium hydride, 7 parts of iodopropane, 45 parts of fuming nitric acid, 3 parts of hydrochloric acid, 5 parts of iron powder, 2 parts, 1.5 parts of thiourea, 1.8 parts of acid-binding agent potassium carbonate, 6 parts of sodium perchlorate, 15 parts of concentrated hydrochloric acid, and 1.5 parts of N,N-diisopropylethylamine.

[0058] The preparation method of the former medicine of described abscisic acid receptor agonist comprises the steps:

[0059] (1) Weighing raw materials: Weighing each raw material according to mole fraction;

[0060] (2) Preparation of N-propyl quinolinone: A. Add quinolinone into the organic solvent N,N-dimethylformamide, and stir at -5°C for 0.8h; B. Separate under argon protection environment Add sodium hydride in batches as a catalyst, and stir for 0.8 hours after the addition; C, drop iodopropane into th...

Embodiment 3

[0074] An original drug of an abscisic acid receptor agonist. The raw materials in molar parts include: 2 parts of quinolinone, 5.5 parts of sodium hydride, 10 parts of iodopropane, 50 parts of fuming nitric acid, 5.5 parts of hydrochloric acid, 5.5 parts of iron powder, 1 part, 1.5 parts of potassium thioacetate, 1.5 parts of acid-binding agent potassium carbonate, and 1.6 parts of N,N-diisopropylethylamine.

[0075] The preparation method of the former medicine of described abscisic acid receptor agonist comprises the steps:

[0076] (1) Weighing raw materials: Weighing each raw material according to mole fraction;

[0077] (2) Preparation of N-propyl quinolinone: A. Add quinolinone into the organic solvent N,N-dimethylformamide, and stir at -4°C for 1 hour; B. Batch under the protection of argon Add sodium hydride as a catalyst, and stir for 1 hour after the addition; C, add iodopropane dropwise into the solution, and react at room temperature for 13 hours; D, add water t...

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Abstract

The invention discloses an abscisic acid receptor stimulant raw drug and a preparation method thereof. The preparation method of the abscisic acid receptor stimulant raw drug comprises the following steps: adding quinolinone and halogenated propane into N, N-dimethyl formamide, and performing alkylation reaction to generate N-propyl quinolinone by taking sodium hydride as a catalyst; adding N-propyl quinolinone into dichloromethane, then, adding fuming nitric acid, and performing nitratlon reaction to generate 7-nitryl-propyl quinolinone; adding 7-nitryl-N-propyl quinolinone into an organic solvent ethanol, then, adding hydrochloric acid and iron powder, and performing hydrogenation reduction reaction to generate 7-amino-N-propyl quinolinone; adding 7-amino-N-propyl quinolinone into an organic solvent acetonitrile, then, adding 4-methyl benzylsulfonyl chloride, performing condensation reaction to generate N-(2-carbonyl-1-propyl-1,2,3,4-4H-quinolinone-6-)-4-p-methyl sulfamide, namely a abscisic acid receptor stimulant by taking N, N-diisopropylethylamine as a catalyst. The method has a relatively high yield; the prepared abscisic acid receptor stimulant raw drug is free of an optical isomer, easy to purify and relatively low in cost.

Description

technical field [0001] The invention relates to the field of plant growth regulators, in particular to an original drug of an abscisic acid receptor agonist and a preparation method thereof. Background technique [0002] In recent years, droughts have become more common and severe in my country. In addition to long-term water shortages in Northwest China and frequent droughts in North China, the frequency of moderate to severe droughts in the Yangtze River Basin and Huanghuai River Basin has also increased significantly, resulting in a substantial reduction in crop yields, and even facing severe droughts. Harvest failure and drought are increasingly becoming the primary environmental factors limiting crop production. [0003] Although traditional drought-resistant breeding has achieved some results, it is limited by the lack of suitable genetic variation in the target species, so the progress of hybrid breeding of drought-resistant varieties of crops has been slow. In addit...

Claims

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Application Information

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IPC IPC(8): C07D215/38A01P21/00
CPCC07D215/38C07C303/02C07C303/44C07C335/32C07D215/227
Inventor 谢如良方小云
Owner 上海绿盎生物科技有限公司
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