Abscisic acid receptor stimulant raw drug and preparation method thereof

Abstract

The invention discloses an abscisic acid receptor stimulant raw drug and a preparation method thereof. The preparation method of the abscisic acid receptor stimulant raw drug comprises the following steps: adding quinolinone and halogenated propane into N, N-dimethyl formamide, and performing alkylation reaction to generate N-propyl quinolinone by taking sodium hydride as a catalyst; adding N-propyl quinolinone into dichloromethane, then, adding fuming nitric acid, and performing nitratlon reaction to generate 7-nitryl-propyl quinolinone; adding 7-nitryl-N-propyl quinolinone into an organic solvent ethanol, then, adding hydrochloric acid and iron powder, and performing hydrogenation reduction reaction to generate 7-amino-N-propyl quinolinone; adding 7-amino-N-propyl quinolinone into an organic solvent acetonitrile, then, adding 4-methyl benzylsulfonyl chloride, performing condensation reaction to generate N-(2-carbonyl-1-propyl-1,2,3,4-4H-quinolinone-6-)-4-p-methyl sulfamide, namely a abscisic acid receptor stimulant by taking N, N-diisopropylethylamine as a catalyst. The method has a relatively high yield; the prepared abscisic acid receptor stimulant raw drug is free of an optical isomer, easy to purify and relatively low in cost.

Description

technical field [0001] The invention relates to the field of plant growth regulators, in particular to an original drug of an abscisic acid receptor agonist and a preparation method thereof. Background technique [0002] In recent years, droughts have become more common and severe in my country. In addition to long-term water shortages in Northwest China and frequent droughts in North China, the frequency of moderate to severe droughts in the Yangtze River Basin and Huanghuai River Basin has also increased significantly, resulting in a substantial reduction in crop yields, and even facing severe droughts. Harvest failure and drought are increasingly becoming the primary environmental factors limiting crop production. [0003] Although traditional drought-resistant breeding has achieved some results, it is limited by the lack of suitable genetic variation in the target species, so the progress of hybrid breeding of drought-resistant varieties of crops has been slow. In addit...

AI Technical Summary

Problems solved by technology

However, the optical configuration of natural abscisic acid in plants is only + / -cis and trans-ABA, and the production cost of traditional chemical synthesis is high. Due to the high price and the difference in activity, abscisic acid has not been widely used. For agricultural production, scientists from all over the world are looking for cheap production methods of natural abscisic acid

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