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Amphipathic superparamagnetic composite hollow microsphere and preparation method thereof

A superparamagnetic and composite microsphere technology is applied in the field of amphiphilic superparamagnetic composite hollow microspheres and their preparation, which can solve the problems of poor stability, limited biomedical application effect, and small particle size adjustment range, and avoid the Decomposition, Ease of Purification and Collection, Enhanced Magnetic Responsiveness

Active Publication Date: 2015-03-04
XINXIANG MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the existing amphiphilic superparamagnetic composite materials often self-assemble through amphiphilic polymers and magnetic nanoparticles to form self-assembled bodies such as micelles, clusters, liposomes, etc. , ionic strength, solvent polarity and other environmental factors are highly dependent, the stability is poor, and the control range of particle size is small, so its biomedical application effect is limited

Method used

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  • Amphipathic superparamagnetic composite hollow microsphere and preparation method thereof
  • Amphipathic superparamagnetic composite hollow microsphere and preparation method thereof
  • Amphipathic superparamagnetic composite hollow microsphere and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0041] Embodiment one: preparation of copolymer solid microspheres P (St-AA) by soap-free seed emulsion polymerization

[0042] Take a three-necked bottle equipped with mechanical stirring, vacuumize and ventilate nitrogen, and repeat three times to ensure that the reaction system is anhydrous and oxygen-free; inject 45mL distilled water into the reaction system, and ventilate nitrogen for 30 minutes under mechanical stirring to remove dissolved in water. Oxygen; then inject 0.5g styrene (St) into the aqueous solution, mechanically stir to make it fully emulsified; heat the reaction system to 70°C in an oil bath, add ammonium persulfate as an initiator, and react for 3 hours to obtain polystyrene seed small Then 4.5g styrene, 1.0g acrylic acid (AA), and 5mL water were injected into the reaction system respectively, and the reaction was continued for 5 hours; after the reaction, a white emulsion was obtained; cooled to room temperature, the reaction solution was distilled under ...

Embodiment 2

[0043] Embodiment two: no soap seed emulsion polymerization method prepares copolymer solid microsphere P (MMA-AA)

[0044] Take a three-necked bottle equipped with mechanical stirring, vacuumize and ventilate nitrogen, and repeat three times to ensure that the reaction system is anhydrous and oxygen-free; inject 45mL distilled water into the reaction system, and ventilate nitrogen for 30 minutes under mechanical stirring to remove dissolved in water. Oxygen; then inject 0.5g methyl methacrylate (MMA) into the aqueous solution, and mechanically stir it to make it fully emulsified; heat the reaction system to 70°C in an oil bath, add potassium persulfate as an initiator, and react for 3 hours to obtain polymethylmethacrylate Methyl methacrylate seed pellets; then 4.5g methyl methacrylate, 1.0g acrylic acid (AA), and 5mL water were injected into the reaction system respectively, and the reaction was continued for 5 hours; after the reaction, a white emulsion was obtained; cooled ...

Embodiment 3

[0045] Embodiment three: polyol method prepares Fe 3 o 4 superparamagnetic nanoparticles

[0046] Take a 100mL three-necked bottle with a condenser, vacuumize and ventilate nitrogen three times, dissolve 720mg of iron acetylacetonate in 40mL of triethylene glycol and inject it into the reaction system; magnetically stir, heat in a sand bath, and slowly raise the temperature to 180°C , keep warm for 30 minutes; then rapidly raise the temperature to 278°C (the boiling point of triethylene glycol), and reflux for 30 minutes to obtain a black magnetic fluid (Fe 3 o 4 The original reaction solution of nanoparticles); cooled to room temperature, washed three times with ethanol / ethyl acetate mixed solvent with a volume ratio of 1:10, and then subjected to magnetic separation. The obtained product was dispersed in ethanol and stored at low temperature.

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Abstract

The invention discloses an amphipathic superparamagnetic composite hollow microsphere and a preparation method thereof. The amphipathic superparamagnetic composite hollow microsphere comprises a hydrophobic copolymer inner cavity, a superparamagnetic nanoparticle interlayer and a hydrophilic polymer brush shell. The amphipathic superparamagnetic composite hollow microsphere disclosed by the invention has the advantages of high magnetic content, good stability, monodispersity and biocompatibility and the like.

Description

technical field [0001] The invention relates to a superparamagnetic composite microsphere and a preparation method thereof, in particular to an amphiphilic superparamagnetic composite hollow microsphere and a preparation method thereof. Background technique [0002] Superparamagnetic nanoparticles are widely used in magnetic resonance imaging, biological separation (cell separation, protein separation) etc.), drug delivery systems, magnetic hyperthermia and gene therapy and other biomedical fields. [0003] Amphiphilic superparamagnetic composite materials are both hydrophilic and lipophilic, and can be widely used in biomedical fields such as magnetic resonance imaging, magnetic hyperthermia, and drug delivery after surface modification. However, the existing amphiphilic superparamagnetic composite materials often self-assemble through amphiphilic polymers and magnetic nanoparticles to form self-assembled bodies such as micelles, clusters, liposomes, etc. , ionic strength...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08F257/02C08F265/04C08F212/08C08F220/06C08F220/14C08F8/42C08F8/24C08J9/26
Inventor 解丽芹陈红丽赵亮冯志伟徐志浩王勉陈淑丽
Owner XINXIANG MEDICAL UNIV
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