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Titanium-based surface antibacterial and bone tissue regeneration-inducing functional coating and its preparation method and application

A technology for bone tissue regeneration and surface antibacterial, applied in the direction of surface reaction electrolytic coating, coating, electrolytic coating, etc., can solve the problems of low bonding strength between coating and substrate, impure phase of coating, no nanofiber, etc. , to achieve the effect of being conducive to large-scale mass production, low price and simple ingredients

Active Publication Date: 2017-05-31
宝鸡卡斯特医疗科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Existing technologies such as plasma spraying, magnetron sputtering, and sol-gel method can obtain strontium-containing fluorohydroxyapatite on the surface of dense metal substrates, but the bonding strength of the obtained strontium-containing fluorohydroxyapatite coating to the substrate Low, easy to peel off during the planting process; the coating phase is impure, there are impurities; and it is not in the form of nanofibers

Method used

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  • Titanium-based surface antibacterial and bone tissue regeneration-inducing functional coating and its preparation method and application
  • Titanium-based surface antibacterial and bone tissue regeneration-inducing functional coating and its preparation method and application
  • Titanium-based surface antibacterial and bone tissue regeneration-inducing functional coating and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] 1) Preprocessing:

[0037] Polish the titanium disc (size Ф14×2mm) with 180#, 360#, 800#, 1000#, 1500# sandpaper in sequence, and then use 99.5% acetone, 99.7% absolute ethanol, and deionized water to ultrasonically for 20 minutes each;

[0038] 2) Electrolyte preparation:

[0039] Will (CH 3 COO) 2 Ca, (CH 3 COO) 2 Sr and β-C 3 h 7 Na 2 o 6 Dissolve P(β-GP) in water, mix well, and prepare electrolyte solution; in the electrolyte solution (CH 3 COO) 2 The concentration of Ca is 0.2mol / L, (CH 3 COO) 2 The concentration of Sr is 0.1mol / L, the concentration of β-GP is 0.02mol / L;

[0040] 3) Micro-arc oxidation:

[0041] With titanium sheet as the anode and stainless steel as the cathode, a DC pulse power supply is used under the conditions of positive voltage 380 volts, negative voltage 50 volts, frequency 150 Hz, duty cycle 25%, distance between cathode and anode plates 9 cm, and electrolyte temperature 10 °C The micro-arc oxidation treatment was performed o...

Embodiment 2

[0052] 1) Preprocessing:

[0053] Polish the titanium disc (size Ф14×2mm) with 180#, 360#, 800#, 1000#, 1500# sandpaper in sequence, and then use 99.5% acetone, 99.7% absolute ethanol, and deionized water to ultrasonically for 20 minutes each;

[0054] 2) Electrolyte preparation:

[0055] Will (CH 3 COO) 2 Ca, (CH 3 COO) 2 Sr and β-C 3 h 7 Na 2 o 6 Dissolve P(β-GP) in water, mix well, and prepare electrolyte solution; in the electrolyte solution (CH 3 COO) 2 The concentration of Ca is 0.3mol / L, (CH 3 COO) 2 The concentration of Sr is 0.15mol / L, the concentration of β-GP is 0.03mol / L;

[0056] 3) Micro-arc oxidation:

[0057] With titanium sheet as the anode and stainless steel as the cathode, a DC pulse power supply is used under the conditions of positive voltage 380 volts, negative voltage 50 volts, frequency 150 Hz, duty cycle 25%, distance between cathode and anode plates 9 cm, and electrolyte temperature 10 °C The micro-arc oxidation treatment was performed ...

Embodiment 3

[0064] 1) Preprocessing:

[0065] Polish the titanium disc (size Ф14×2mm) with 180#, 360#, 800#, 1000#, 1500# sandpaper in sequence, and then use 99.5% acetone, 99.7% absolute ethanol, and deionized water to ultrasonically for 20 minutes each;

[0066] 2) Electrolyte preparation:

[0067] Will (CH 3 COO) 2 Ca, (CH 3 COO) 2 Sr and β-C 3 h 7 Na 2 o 6 Dissolve P(β-GP) in water, mix well, and prepare electrolyte solution; in the electrolyte solution (CH 3 COO) 2 The concentration of Ca is 0.2mol / L, (CH 3 COO) 2 The concentration of Sr is 0.1mol / L, the concentration of β-GP is 0.02mol / L;

[0068] 3) Micro-arc oxidation:

[0069] With titanium sheet as the anode and stainless steel as the cathode, a DC pulse power supply is used under the conditions of positive voltage 400 volts, negative voltage 80 volts, frequency 150 Hz, duty cycle 25%, distance between cathode and anode plates 9 cm, and electrolyte temperature 10 °C The micro-arc oxidation treatment was performed o...

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Abstract

The invention provides a titanium-based surface antibacterial and bone tissue regeneration induced functional coating as well as a preparation method and application thereof. The preparation method comprises the following steps: firstly preparing an electrolyte, taking titanium or a titanium alloy as an anode and taking stainless steel as a cathode, preparing a porous TiO2 coating containing calcium, phosphorus and strontium by adopting a micro-arc oxidation technology, then sequentially performing hydro-thermal treatment by virtue of a fluorine-containing solution, and also loading human bone morphogenetic protein-2 to finally obtain a target coating disclosed by the invention, wherein the coating consists of an inner layer which is bonded on the surface of a matrix and a surface layer which is bonded on the surface of the inner layer, the inner layer is a porous TiO2 layer containing calcium, phosphorus and strontium, and the surface layer is a three-dimensional nano-fibrous hydroxyapatite layer which is loaded with human bone morphogenetic protein-2 and contains strontium and fluorine. No non-continuous interface is formed between the coating and the matrix, so that the coating provided by the invention has relatively good bonding strength and structure stability performance, also has good antibacterial and bone tissue regeneration inducing functions, and can be used for significantly promoting the osteogenic function of cells, promoting new bone formation and inhibiting the adhesion and growth of bacteria.

Description

technical field [0001] The invention belongs to the technical field of surface modification of medical metal materials, and relates to a titanium-based surface antibacterial and bone tissue regeneration inductive functional coating and a preparation method and application thereof. Background technique [0002] Titanium and its alloys have the advantages of good corrosion resistance, strong chemical stability, and excellent biocompatibility, and are widely used in orthopedics, orthopedics, and stomatology. However, titanium and its alloys are biologically inert materials, which cannot form a chemical combination with the host bone after implantation, and have no ability to promote new bone formation, which seriously affects the implantation effect; in addition, because titanium and its alloys do not have antibacterial function, Bacterial infection is likely to occur after the operation, resulting in implant failure. In view of the above two points, it is necessary to modify ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/32A61L27/54A61L27/06A61L27/56C25D11/26
Inventor 周建宏冯爱玲段旭朝张亚妮王参军张建伟
Owner 宝鸡卡斯特医疗科技有限公司
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