Good-compatibility and absorbable medical suture line and production method thereof

A suture and compatibility technology, applied in the field of medical sutures, can solve the problems of slow degradation rate, easy cell adhesion and supply, etc., to achieve the effect of increasing smoothness, reducing tissue drag, and reducing pain

Active Publication Date: 2015-11-25
安徽省康宁医疗用品有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] PGA fiber is very suitable for cell adhesion and reproduction, but due to its fast degradation rate, it cannot provide sufficient strength before tissue formation; compared with PGA fiber, the degradation rate of PLA fiber is slower, but PLA is hydrophobic, Cells cannot adhere and reproduce well on fibers. When using sutures made of this type of polymer, it is difficult to meet the two conditions of slow degradation rate and easy cell adhesion and reproduction.

Method used

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  • Good-compatibility and absorbable medical suture line and production method thereof

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preparation example Construction

[0031] Reference figure 1 , The method for preparing an absorbable medical suture with good compatibility provided by the present invention includes the following steps:

[0032] S1. Preparation of suture fiber: mix polyglycolide, modified polylactic acid, polylactic acid, hyaluronic acid, methyl methacrylate, epoxidized soybean oil, and tea tree oil. -300r / min stirring for 4-6h, heating to 100-120℃, extruding with twin screw extruder, water cooling, air drying, pelletizing to obtain masterbatch; heating to 150-170℃ to melt masterbatch and defoam , Obtain primary fibers through a spinneret; stretch the primary fibers in a water bath at 40-60°C to obtain suture fibers;

[0033] S2. Preparation of coating solution: after adding polycaprolactone to ethanol and stirring, adding calcium stearate powder and stirring, and heating to 40-50°C to obtain a coating solution;

[0034] S3. Coating and knitting: coating the suture fiber obtained in S1 with the coating solution obtained in S2, dry...

Embodiment 1

[0037] A compatible and absorbable medical suture thread. Its raw materials by weight include: 40 parts of polyglycolide, 10 parts of modified polylactic acid, 70 parts of polylactic acid, 10 parts of hyaluronic acid, and 7 parts of methyl methacrylate. Parts, 4 parts epoxidized soybean oil, 4 parts tea tree oil, 1 part polycaprolactone, 0.3 parts calcium stearate, 15 parts ethanol;

[0038] Among them, the preparation method of modified polylactic acid is as follows: add 2 parts of polylactic acid to 20 parts of chloroform by weight to dissolve, blow in nitrogen, add 6 parts of 2-ethylhexyl methacrylic anhydride, and heat to 70°C, Incubate for 2 hours, cool, add dropwise to 150 parts of ethanol, filter with suction, heat up to 40°C, and vacuum dry for 15 hours to obtain intermediate materials; add 7 parts of itaconic acid to 40 parts of oxalyl chloride in parts by weight, heat up to 90°C, keep warm 3h, suction filtration, add the filter cake to 40 parts of ether and soak for 22h...

Embodiment 2

[0044] An absorbable medical suture thread with good compatibility. Its raw materials by weight include: 20 parts of polyglycolide, 20 parts of modified polylactic acid, 50 parts of polylactic acid, 20 parts of hyaluronic acid, and 5 parts of methyl methacrylate. Parts, 6 parts of epoxidized soybean oil, 2 parts of tea tree oil, 5 parts of polycaprolactone, 0.1 part of calcium stearate, 30 parts of ethanol;

[0045] Among them, the preparation method of modified polylactic acid is as follows: add 4 parts of polylactic acid to 10 parts of chloroform by weight to dissolve, blow in nitrogen, add 13 parts of 2-ethylhexyl methacrylic anhydride, and heat to 50°C, Incubate for 4 hours, cool, add dropwise to 100 parts of ethanol, filter with suction, heat up to 60°C, and vacuum dry for 10 hours to obtain intermediate materials; add 11 parts of itaconic acid to 30 parts of oxalyl chloride in parts by weight, heat up to 110°C, keep warm 2h, suction filtration, add the filter cake to 60 par...

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Abstract

The invention discloses a good-compatibility and absorbable medical suture line which comprises, by weight, 20-40 parts of polyglycollide, 10-20 parts of modified polylactic acid, 50-70 parts of polylactic acid, 10-20 parts of hyaluronic acid, 5-7 parts of methyl methacrylate, 4-6 parts of epoxidized soybean oil, 2-4 parts of tea tree oil, 1-5 parts of polycaprolactone and 0.1-0.3 part of calcium stearate. The invention further discloses a production method of the good-compatibility and absorbable medical suture line. The method includes the steps of S1, producing suture line fibers; S2, preparing coating solution; S3, braiding coating. The medical suture line has the advantages that the suture line is good in compatibility with biological tissues, good in mechanical performance, resistant to degradation and simple to operate, adhesion and reproduction of cells on the suture line are facilitated, and industrial production is facilitated.

Description

Technical field [0001] The invention relates to the technical field of medical sutures, in particular to an absorbable medical suture with good compatibility and a preparation method thereof. Background technique [0002] Surgical suture thread refers to a special thread used for wound ligation, suture hemostasis, and tissue suture during surgery. According to its biodegradability, it can be divided into two categories: non-absorbable thread and absorbable thread. Absorbable sutures include natural fibers and synthetic polymer sutures. [0003] Synthetic polymer sutures include polyglycolide (PGA) sutures, polylactic acid (PLA) sutures, polydioxanone (PDS) sutures and the like. Absorbable sutures are degraded and absorbed in the body, avoiding the pain caused by the second operation to the patient, and sutures with different degradation times can be selected according to actual surgical needs. [0004] PGA fiber is very suitable for cell adhesion and reproduction, but due to its f...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L17/12A61L17/10A61L17/14D06M15/507D06M13/188D01F8/14D01F1/10D06M101/32
Inventor 祁建兵
Owner 安徽省康宁医疗用品有限公司
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