Developing embolism microsphere for treating tumor diseases through minimally invasive interventional therapy and preparation method thereof

Abstract

The invention relates to a developing embolism microsphere for treating tumor diseases through minimally invasive interventional therapy and a preparation method thereof and belongs to the technical field of medical materials. A functional macromolecule with biocompatibility is formed through the cross-linking polymerization of cross-linking agent iodobenzene compound and cross-linking agent alkyl acid derivative. According to the technology provided by the invention, the defect of developing by adding a developing agent in a traditional operation embolism process is overcome, the operation risk is reduced and convenience is brought for treating tumor diseases through the minimally invasive interventional therapy; the developing microsphere produced according to the preparation process has the characteristics of blocking X ray or weakening X ray and has excellent flexibility and flexibility; and meanwhile, the traditional embolism microsphere is dyed, so that the doctor can conveniently observe in the operation process; the embolism microsphere prepared according to the process is yellow and free from dyeing treatment; the operation is simple and feasible.

Description

technical field [0001] The present invention relates to an imageable embolic microsphere for minimally invasive interventional therapy to treat tumor diseases and a preparation method thereof, in particular to an imageable embolic microsphere with good deformation elasticity for minimally invasive interventional therapy for tumoral disease The preparation process belongs to the technical field of medical materials. Background technique [0002] In recent years, interventional embolization has played an increasingly important role in clinical medicine, especially in the treatment of cancer tumors rich in blood vessels such as liver cancer, kidney cancer and uterine fibroids. It has become the preferred alternative for the treatment of tumors that cannot be surgically removed. At present, commonly used embolic materials for interventional embolization include microspheres, microcatheters, coils, silk threads, etc., and microspheres are highly targeted to specific tissues and ...

AI Technical Summary

Problems solved by technology

In order to achieve better embolization and imaging effects, it is necessary to mix embolization microspheres and ethyliodol to form a stable suspension system during the process of adding ethyliodol, but such a combination is often unstable, which means that the injection combination The substance needs to be prepared immediately before injection, and the ethyliodol and embolic microspheres may be in different positions in the tissue after injection, which greatly increases the difficulty of the doctor's operation. At the same time, the use of contrast medium will also directly stimulate blood vessels. , bringing additional risk

[0006] WO2014 / 152488 describes a polymer microsphere Activate the preformed hydrogel beads by nucleophilic attack, and then covalently attach iodine-containing compounds to the polymer microspheres to prepare visualization microspheres. This method prepares visualization microspheres by chemically modifying the surface of the microspheres, but the operation steps It is cumbersome, and due to the nature of the network structure of the microspheres and the large steric hindrance of the reaction, the preparation of the visualized microspheres requires a higher temperature (50°C) and a longer reaction time (more than 24h), and the reaction conditions are relatively low. harsh

[0007] US2016 / 0193367 describes the surface chemical modification of a polymer microsphere under the catalysis of methanesulfonic acid and an acetal compound containing iodobenzene at 80°C. The prepared microsphere can be developed under X-ray, but Due to the network structure of the microspheres (lower reactivity), the reaction temperature is higher, which may adversely affect the physical properties of the microspheres such as size, sphericity, swelling and compressibility

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