An electrospun nanofiber with discrete and uneven drug distribution characteristics and its preparation method

A technology of electrospinning nanofibers and uniform distribution, which is applied in the field of materials science, can solve the problems of poor slow-release effect of nanofibers, and achieve remarkable technological progress, smooth fiber surface, and simple preparation process

Inactive Publication Date: 2019-02-15
UNIV OF SHANGHAI FOR SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] Aiming at the above-mentioned technical problems in the prior art, the present invention provides an electrospun nanofiber with discrete and uneven drug distribution characteristics and a preparation method thereof, the electrospun nanofiber with discrete and uneven drug distribution characteristics The technical problem that the sustained-release effect of the nanofiber in the prior art is not good is solved by the preparation method thereof

Method used

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  • An electrospun nanofiber with discrete and uneven drug distribution characteristics and its preparation method
  • An electrospun nanofiber with discrete and uneven drug distribution characteristics and its preparation method
  • An electrospun nanofiber with discrete and uneven drug distribution characteristics and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Example 1: Implementation of coaxial electrospinning process on one side in parallel

[0028] 8 grams of polyvinylpyrrolidone and 2 grams of ketoprofen were co-dissolved in 100 grams of ethanol to prepare the working fluid for the outer layer. Put 44 grams of ethyl cellulose into 200 grams of ethanol to make a mother liquor with good spinning properties. The above mother liquor was equally divided into two parts. A part of them directly uses the sheath liquid of the parallel coaxial side, and the other part is added with 8 grams of ketoprofen, and after co-dissolving into a uniform solution, it is used as the core liquid of the parallel coaxial side. Fill the above three working fluids into syringes and install them on the corresponding syringe pumps, connect the fluids of each layer to each inlet of the three-stage combined spinning head, and connect the high-voltage spinning head and the high-voltage electrostatic generator.

[0029] According to the following proce...

Embodiment 2

[0033] Example 2: Characterization analysis of the morphology and structure of nanofibers with discrete and uneven distribution of drugs

[0034] Field emission scanning electron microscopy (FESEM) was used to observe the surface of the fiber prepared in Example 1 after spraying gold, and the results were as follows Figure 4 shown. The prepared fiber exhibits a good linear state, no beading structure occurs, the fiber surface is smooth, and the fiber accumulation is uniform. The diameter is 710 ± 140 nm, the distribution is relatively uniform, and the diameter distribution is relatively concentrated.

[0035] The internal structure of the prepared fiber was observed by high-resolution transmission electron microscope (TEM), and the results were as follows: Figure 5 As shown, the juxtaposed side of the nanofibers contains a clear coaxial structure, and the sheath of the coaxial side shows a lower gray feature because the blank does not contain drugs.

[0036] Schematic dia...

Embodiment 3

[0039] The sustained and controlled release performance of ketoprofen provided by nanofibers with discrete and uneven drug distribution characteristics:

[0040] According to the 2015 edition of Chinese Pharmacopoeia Appendix ⅩD Release Test Method 2, the RCZ-8A intelligent dissolution tester was used to conduct the in vitro dissolution test on the drug-loaded nanofibers obtained above. The speed was controlled at 50rpm, the temperature was 37±0.1°C, and the dissolution medium was 900mL of pH7.2 phosphate buffer solution to investigate the in vitro drug release performance of nanofibers with discrete and uneven drug distribution characteristics. Sampling 5mL at the scheduled time to obtain a sample of the dissolution solution, and immediately replenish the same volume of isothermal fresh medium. After appropriate dilution of the sample, at λ max = 257 nm place, adopt ultraviolet-visible spectrophotometer to carry out ultraviolet measurement, calculate drug ketoprofen dissolu...

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Abstract

The invention provides an electro-spinning nano fiber with discrete uneven distribution characteristics of drugs. The fiber comprises a core part. A sheath part is arranged at the outer circle of the core part. The core part and the sheath part extend coaxially. The inside of the core part is loaded with drugs. One side of the sheath part is provided with a parallel outer surface layer. The parallel outer surface layer extends in the length direction, and covers 40-60% of the outer circle of the sheath part. The inside of the parallel outer surface layer is loaded with drugs. The invention further provides a preparation method of the nano fiber, and a device for achieving the preparation method. The electro-spinning nano fiber with discrete uneven distribution characteristics of drugs has the advantages of being simple in preparation process, effective in a single step, clear in the structure of the prepared nano fiber, small in nano-particle diameter, good in linearity, uniform in diameter distribution and smooth in fiber surface. The uneven distribution characteristics of drugs provides an effective implementation method for the design of a plurality of new drug slow release materials.

Description

technical field [0001] The invention belongs to the field of materials science, and relates to a technology for establishing a structure-activity relationship of a novel nano-level substance, in particular to an electrospun nanofiber with discrete and uneven drug distribution characteristics and a preparation method thereof. Background technique [0002] High-voltage electrospinning technology (electrospinning) is a top-down nano-manufacturing technology. The jet is formed by overcoming the liquid surface tension and viscoelastic force of the droplets at the tip of the nozzle by applying an electric field force. Under the joint action of Coulomb force and surface tension, the atomized liquid jet is bent, stretched, and split by high frequency, and is stretched tens of millions of times within tens of milliseconds. After solvent volatilization or melt cooling, nanometer particles are obtained at the receiving end. grade fiber. This technology has simple process, convenient o...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): D01D5/00D01D5/32D01D5/34D01F8/02D01F8/10D01F1/10
CPCD01D5/003D01D5/0069D01D5/32D01D5/34D01F1/10D01F8/02D01F8/10
Inventor 余灯广李娇娇王庆李海鹏曲杨璐
Owner UNIV OF SHANGHAI FOR SCI & TECH
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