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Medicine applying membrane for operative wounds

A wound and drug delivery technology, applied in the field of medical materials, can solve problems such as poor ability to absorb exudate, poor adhesion of the wound surface, and poor hemostatic effect of materials, and achieve the effects of promoting healing, improving adhesion and preventing cross-infection.

Inactive Publication Date: 2017-11-24
田秋珍
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The technical problem to be solved by the present invention: in view of the short drug effect time of the current chitosan sustained-release drug delivery film, the film material directly prepared with chitosan as a raw material has poor ability to absorb exudate, and is not tightly attached to the wound surface, resulting in The hemostatic effect of the material is poor, which limits its application in the field of medicine. The invention provides a drug-delivery membrane for surgical wounds

Method used

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  • Medicine applying membrane for operative wounds

Examples

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Effect test

example 1

[0017] Take the herring skin, wash the fish skin twice with deionized water, and then air-dry it naturally, then put the air-dried fish skin into a pulverizer and pulverize it, pass through a 40-mesh sieve, weigh 300g of the sieved fish skin powder and soak it in 3L mass fraction In 0.3% sodium hydroxide solution for 2 hours, filter to obtain the filter residue, wash the filter residue with deionized water until the washing liquid is neutral, and obtain the pre-treated fish skin powder, add the pre-treated fish skin powder to 3L of 3% hydrogen peroxide by mass fraction, Stir at 300r / min for 3 hours, filter to obtain a filter cake, wash the filter cake with deionized water 3 times, and then wash the filter cake 2 times with absolute ethanol to obtain rough fish skin powder, measure 250mL methanol, 80mL acetic acid, add Stir in 600mL of deionized water at 300r / min for 20min, then add 200g of coarsely processed fish skin powder, continue stirring for 15h, then filter to obtain the...

example 2

[0019] Take the grass carp skin, wash the fish skin twice with deionized water, and then air-dry it naturally, then put the air-dried fish skin into a pulverizer and grind it, pass through a 40-mesh sieve, weigh 400g of the sieved fish skin powder and soak it in 4L mass fraction 0.3% sodium hydroxide solution for 2 hours, filter to obtain the filter residue, wash the filter residue with deionized water until the washing liquid is neutral, and obtain the pre-treated fish skin powder, add the pre-treated fish skin powder to 4L of 3% hydrogen peroxide by mass fraction, Stir at 350r / min for 4 hours, filter to obtain a filter cake, wash the filter cake with deionized water 4 times, and then wash the filter cake 2 times with absolute ethanol to obtain rough fish skin powder, measure 275mL of methanol, 90mL of acetic acid, add Stir in 675mL of deionized water at 350r / min for 25min, then add 220g of coarsely processed fish skin powder, continue stirring for 18h, then filter to obtain t...

example 3

[0021]Take silver carp skin, wash the fish skin with deionized water for 3 times, then air-dry naturally, then put the air-dried fish skin into a pulverizer and pulverize, pass through a 40-mesh sieve, weigh 500g of sieved fish skin powder and soak in 5L quality The fraction is 0.3% sodium hydroxide solution for 3 hours, filter to obtain the filter residue, wash the filter residue with deionized water until the washing liquid is neutral, and obtain the primary treatment fish skin powder, add the primary treatment fish skin powder to 5L mass fraction of 3% hydrogen peroxide , stirred at 400r / min for 5h, filtered to obtain a filter cake, washed the filter cake with deionized water for 5 times, and then washed the filter cake with absolute ethanol for 3 times to obtain rough fish skin powder, measure 300mL of methanol, 100mL of acetic acid, Add 750mL of deionized water, stir at 400r / min for 30min, then add 240g of coarsely processed fish skin powder, continue stirring for 20h, the...

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Abstract

The invention relates to a medicine applying membrane for an operative wound, and belongs to the technical field of medical materials. According to the medicine applying membrane for the operative wound, black carp skin is used as a raw material, repeated degreasing, discolouring and impurity-removing treatments are conducted, and fish skin collagen is obtained; then chitosan is stem-grafted by using vanilline in a mixed solution of isopropanol and ethyl alcohol, and vanilline stem grafted chitosan is prepared; and finally the fish skin collagen and the vanilline stem grafted chitosan are compounded, after vacuum defoamation is conducted, tape casting and membrane forming are conducted, and the medicine applying membrane for the operative wound are prepared. According to the medicine applying membrane for the operative wound, by using good biological compatibility of the fish skin collagen, a fiber net structure is formed in the wound, adhesive force of regenerative cells is improved, antibacterial clotting action of chitosan, sodium alginate tech grade and the like is in synergy, and healing of tissues is promoted, the medicine applying membrane for the operative wound is high in bacteriostatic activity and good in absorption seepage capacity and hemostatic effect, dust and microorganism can be effectively prevented from intruding, cross infection is prevented, wounded tissue is repaired, and wound healing is promoted.

Description

technical field [0001] The invention relates to a drug-medicating membrane for surgical wounds, belonging to the technical field of medical materials. Background technique [0002] Film formulation is a new thin-film dosage form developed in recent years by dissolving and uniformly dispersing drugs in film-forming materials. It can be pasted on the skin or mucous membrane wound surface or ulcer surface, and the medicine in the drug-loaded film can be directly absorbed through the mucous membrane, which improves the effective absorption of the medicine and achieves a good therapeutic effect. [0003] Hesperidin, in the citrus genus, those with developed and thinner mesocarp systems contain more hesperidin. Hesperidin mainly has antitussive and antioxidant effects, and also has the effects of maintaining osmotic pressure, enhancing capillary toughness, shortening bleeding time, and lowering cholesterol. Clinical preparations are used for adjuvant treatment of cardiovascular s...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/70A61K31/7048A61K31/734A61K47/36A61K47/42A61P17/02A61P31/04A61P31/02
CPCA61K9/7007A61K31/7048A61K31/734A61K47/36A61K47/42A61K2300/00
Inventor 吴兴旺杨阳
Owner 田秋珍
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