In-situ cross-linked hydrogel

Abstract

The invention discloses in-situ cross-linked hydrogel which is prepared from a polymer main agent and a cross-linking agent in a water solution through cross-linking, wherein the polymer main agent contains furan groups on a side chain; the cross-linking agent contains more than two carbon-carbon double bonds; and as diene, the polymer main agent is subjected to a Diels-Alder cycloaddition reaction with dienophile of the cross-linking agent in a water solvent, and thus the hydrogel is prepared. The hydrogel is free of organic solvent, and is safe and environment-friendly; no catalyst is needed when the hydrogel is prepared, only an in-situ cross-linking reaction is needed, and cross-linking can be carried out at normal temperature; the hydrogel is large in cross-linking density and rapid in reaction process, and can be applied to leaking stoppage or hemostasis; and meanwhile, when the raw materials (the polymer main agent and the cross-linking agent) of the hydrogel are prepared, the yield is high, preparation processes are simple, and large-scale production and application can be easily achieved.

Description

technical field [0001] The invention relates to the field of hydrogels, in particular to an in-situ cross-linked hydrogel, in particular to an in-situ cross-linked hydrogel for leak plugging or hemostasis. Background technique [0002] As a high water absorption and high water retention material, hydrogel is widely used in many fields, such as: water retention in arable land in arid areas, humectant in antipyretic patches and cosmetic mask products, anti-condensation agent in construction, petrochemical industry Water blocking agent, medical hemostatic material, drug carrier, etc., especially for leak plugging or hemostasis. There are many methods for preparing hydrogels, among which, among many types of chemical reactions, the Diels-Alder cycloaddition reaction (D-A reaction) is a reaction that is very suitable for in-situ crosslinking hydrogels. [0003] Nabendu Pramanik et al. prepared polyfurfuryl methacrylate containing diene furan side groups, using 4,4-diaminobipheny...

AI Technical Summary

Problems solved by technology

However, first, the dienophile is a macromolecule, and the reactive carbon-carbon double bond is at both ends of the macromolecule. In this way, during the D-A reaction, the carbon-carbon double bond is easily wrapped by the main structure of the macromolecule, PEG, resulting in a D-A reaction. The efficiency is very low; secondly, the cross-linked structure of the hydrogel prepared by the dienophile (PEG-AMI) of macromolecular structure has large gaps and is not compact, so it is not suitable for plugging or hemostasis; thirdly, the amphiphile The preparation of alkenes is complicated. First, N-(isopropanoyl)-maleimide (AMI) is synthesized by maleic anhydride and alanine, and then the amphiphile is prepared by reacting AMI with polyethylene glycol (PEG). Enbody (PEG-AMI); Fourth, the preparation conversion rate of dienophile (PEG-AMI) is low and can only reach 23%

[0007] At the same time, the existing hydrogel products are basically cross-linked in the polymerization stage of the preparation process. The final product is in the form of powder or particles after drying, and becomes a hydrogel after absorbing water, and then further applied. In this state, During the application process, the polymer molecular chains in the hydrogel are always a cross-linked network structure, which does not have fluidity

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