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Method for preparing fructose or mannitol in combination with enzymatic catalysis and chemical catalysis

A technology of chemical catalysis and mannitol, which is applied in chemical instruments and methods, preparation of hydroxyl compounds, preparation of organic compounds, etc., can solve complex mannitol production process, failure to meet market demand, low yield of fructose and mannitol, etc. problems, to achieve the effect of effectively controlling reaction selectivity, inhibiting the formation of by-products, and high conversion rate of glucose

Inactive Publication Date: 2018-01-09
BEIJING FORESTRY UNIVERSITY
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  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the complicated production process and high production cost of mannitol, the price of mannose is relatively expensive
[0006] Some of the above-mentioned production methods of fructose and mannitol are only theoretical production, and cannot realize industrialization at all; High cost, large consumption of raw materials, low output, high price and unable to meet market demand

Method used

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  • Method for preparing fructose or mannitol in combination with enzymatic catalysis and chemical catalysis

Examples

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preparation example Construction

[0031] Preparation of nickel / activated carbon: a certain amount of Ni(NO 3 ) 2 ·6H 2 0 was dissolved in water, and slowly added dropwise to the suspension of activated carbon after being completely dissolved, stirred at room temperature for 12 hours, and after being vacuum-dried, the obtained catalyst precursor Ni(NO 3 ) 2 / AC was placed in a tube furnace, activated at 450°C for 6 hours under nitrogen-hydrogen mixture (containing 5-20% hydrogen), and cooled to room temperature to obtain a nickel / activated carbon catalyst with a certain loading capacity.

[0032] Preparation of other metal catalysts: cobalt / activated carbon, nickel / silica, iron / silica, cobalt / silica, cobalt / ASA The preparation process of the catalyst is similar to the preparation of nickel / activated carbon, the difference is that the carrier is used separately Silicon dioxide, activated carbon, and ASA are used, and the supported metals are iron, nickel, etc., and different metal-supported catalysts can be o...

Embodiment 1

[0034](1) According to the mass ratio of D-pyranose oxidase (pyranose oxidase, EC1.1.3.10), catalase, glucose and water in the ratio of 1:1:100:1000, prepare 10g of glucose and 100g of water After mixing to obtain a glucose solution, add 100 mg of D-pyranose oxidase and 100 mg of catalase to the glucose solution, adjust the pH to 5 with citric acid, and then shake the mixture at 30°C (150 rpm) Carry out enzymatic reaction in 12 hours, obtain 2-ketoglucose aqueous solution; Add catalase in this step and can effectively decompose hydrogen peroxide produced in the enzymatic oxidation reaction process;

[0035] In this step, the conversion rate of glucose and the yield of 2-ketoglucose can be qualitatively and quantitatively analyzed by high performance liquid chromatography (HPLC). The detection conditions are as follows: Agilent 1260 liquid chromatograph, column Carbomix Ca-NP10 (10um, 8% cross-linking degree, 7.8×300mm); mobile phase: ultrapure water; column temperature: 80°C; ...

Embodiment 2

[0040] Same as Example 1, only the ethanol in step (2) is replaced with methanol.

[0041] The resulting fructose yield was 93.6%.

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Abstract

The invention discloses a method for preparing fructose or mannitol in combination with enzymatic catalysis and chemical catalysis. The method comprises the following steps: firstly preparing a 2-ketoglucose aqueous solution, adding alcohols and poly-phase metallic catalysts into the 2-ketoglucose aqueous solution and then performing hydrogenation reaction under different hydrogen pressure conditions to obtain the fructose or the mannitol. The method disclosed by the invention has the beneficial effects that the process of converting glucose into the fructose or the mannitol is completed by utilizing a two-step method; the enzymatic oxidation reaction and the chemical hydrogenation catalytic reaction can be subjected to continuous reaction through a one-pot method, an intermediate productis not required to be separated, reaction conditions are mild, an environment-friendly effect is realized, and the corrosion to equipment is low; the reaction selectivity can be effectively controlled, the formation of a by-product is inhibited, and the yield, the quality and the selectivity of the fructose or the mannitol are improved; the method disclosed by the invention is simple in process, safe, convenient to operate, simple in product post-treatment, high in glucose conversion rate, high in fructose and mannitol yield and very good in fructose and mannitol selectivity under different conditions.

Description

technical field [0001] The invention relates to a method for preparing fructose or mannitol by combining enzymatic catalysis with chemical catalysis, in particular to a method for preparing crystalline fructose or mannitol in one pot in an alcohol-water system. Background technique [0002] Fructose (C 6 h 12 o 6 ) is a six-carbon monosaccharide, which is an isomer of glucose, and constitutes the three main components of blood sugar together with glucose and galactose. The sweetness of fructose is 1.8 times that of sucrose. Compared with sucrose, fructose has the advantages of good taste, high sweetness, low glycemic index and not easy to cause dental caries. Fructose exists in many foods, such as honey, fruit, berries, melons, and some root vegetables such as beets, sweet potatoes, onions, etc. contain fructose. Since the commercialization of fructose products in the 1960s, with the continuous updating of production technology and the extensive needs of the food industr...

Claims

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Application Information

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IPC IPC(8): C07H3/02C07H1/00C07C29/149C07C31/26C12P7/24
CPCY02P20/584
Inventor 宋国勇孙建奎王波黄鸿志
Owner BEIJING FORESTRY UNIVERSITY
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