Macromolecule-metallic oxide compound as well as preparation and application thereof

A technology of polymers and oxides, applied in the fields of nanotechnology and biomedical engineering, can solve the problems of inability to guarantee blood circulation characteristics, poor physiological stability, weak chelation, etc., achieve good imaging effects, reduce preparation costs, and heat efficiency high effect

Active Publication Date: 2018-03-06
江苏纳菲生物医药科技有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

This method has a long period, and at the same time, due to the use of ligand exchange, the chelation between the surface ligand and iron ions is weak, and it is easy to fall off and release free iron ions to cause hypersensitivity.
[0006] CN101002951A discloses a method for preparing hydrophilic iron oxide complex molecules by a polyol method, which can easily prepare hydrophilic, monodisperse, high-crystallinity iron oxide complex molecules, but because the surface organic matter content is less , so its physiological stability is poor, and its blood circulation characteristics in vivo cannot be guaranteed.

Method used

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  • Macromolecule-metallic oxide compound as well as preparation and application thereof
  • Macromolecule-metallic oxide compound as well as preparation and application thereof
  • Macromolecule-metallic oxide compound as well as preparation and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0064] Synthetic steps:

[0065] First, measure 20ml of diethylene glycol with a graduated cylinder, then weigh 2g of sodium hydroxide with a precision balance, and dissolve it in diethylene glycol by ultrasonication, heating, and stirring to form solution B, solution B Put it in an oven at 70°C to keep the temperature; secondly, weigh 6g of polyacrylic acid with a weight average molecular weight of 1000Da in a beaker, then weigh 500ml of diethylene glycol in a beaker, stir and ultrasonically dissolve the two; quickly weigh 2g of anhydrous ferric chloride was dissolved in a mixture of diethylene glycol and polyacrylic acid by heating, ultrasonication and stirring to form solution A (the solution was brown); finally, solution A was placed in a three-necked flask Keep the temperature at 200°C for 20 minutes in a microwave reactor, then quickly add hot solution B, the reaction proceeds instantaneously, and keep the temperature for 30 minutes. After cooling, polyacrylic acid-iron...

Embodiment 2

[0067] Synthetic steps:

[0068] First, measure 100ml of ethylene glycol with a graduated cylinder, then weigh 8g of sodium acetate with a precision balance, and dissolve it in ethylene glycol through ultrasonication, heating, and stirring to make solution B, and put solution B in an oven at 70°C to keep the temperature Next, take weight-average molecular weight and be that polyacrylic acid 12g of 5000Da is in the beaker, then weigh 360ml ethylene glycol in the beaker, stirring, ultrasonic make both dissolve; Quickly weigh ferric sulfate 8g, by heating, ultrasonic, stirring Dissolve it in a mixture of ethylene glycol and polyacrylic acid to form solution A (the solution is brown); finally, put solution A in a three-necked flask and keep the temperature at 220°C for 10 minutes in a microwave reactor, then quickly add hot solution B , The reaction proceeds instantaneously, and the temperature is kept constant for 10 minutes. After cooling, polyacrylic acid-iron oxide composite ...

Embodiment 3

[0070] Synthetic steps:

[0071] First, measure 100ml of propylene glycol with a measuring cylinder, then weigh 15g of sodium borohydride with a precision balance, and dissolve it in propylene glycol by ultrasonication, heating, and stirring to form solution B, which is placed in an oven at 70°C to keep the temperature constant; secondly, Weigh 30g of polyacrylic acid with a weight average molecular weight of 3000Da in a beaker, then weigh 1000ml of propylene glycol in a beaker, stir and ultrasonically dissolve the two; quickly weigh 30g of ferric hydroxide, and dissolve it in the beaker by heating, ultrasonic and stirring. In the mixture of propylene glycol and polyacrylic acid, prepare solution A (the solution is brown); finally, put solution A in a three-necked flask and keep the temperature in a microwave reactor at 240°C for 20 minutes, then quickly add hot solution B, and the reaction proceeds instantaneously. Constant temperature 30min. After cooling, polyacrylic acid-...

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Abstract

The invention discloses a macromolecule-metallic oxide compound. The macromolecule-metallic oxide compound comprises a metallic oxide particle located in the center and a macromolecule modified on thesurface of the metallic oxide particle, the macromolecule has a functional group capable of being bonded with a metal in the metallic oxide, and the density of a binding site of the polymer and the surface of the metallic oxide is more than 2 binding sites per square nanometer. The invention further discloses a preparation method of the macromolecule-metallic oxide compound and application of themacromolecule-metallic oxide compound as a nuclear magnetic resonance contrast medium and an iron supplement agent. The disclosed macromolecule-metallic oxide compound greatly prolongs the circulation time of the macromolecule-metallic oxide compound in a body and effectively overcomes the defect that the existing contrast medium causes the hypersensitivity, and as the compound has superparamagnetism and has the function of participating in iron metabolism, the macromolecule-metallic oxide compound can be applied as the nuclear magnetic resonance contrast medium and the iron supplement agentused for treating iron-deficiency anaemia.

Description

technical field [0001] The invention relates to the technical fields of nanotechnology and biomedical engineering, in particular to a polymer-metal oxide compound. Background technique [0002] In recent years, superparamagnetic nanoparticles represented by iron oxide have been widely used in various fields of biomedicine due to their unique physical and chemical properties, such as: biomagnetic separation, targeted drug delivery, gene transfection, immunodiagnosis, deficiency Ferric anemia treatment, enhanced magnetic resonance imaging and other fields. In the above fields, nanometer-sized iron oxide particles have been extensively researched and applied in the superparamagnetic magnetic resonance contrast agent and the treatment of iron-deficiency anemia. [0003] At present, the molecular structure of iron oxide nanoparticles in the above applications is mainly a polymer compound of ferric oxide or ferric oxide, and commercial superparamagnetic iron oxide complex molecul...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K49/18A61K49/12A61K9/51A61K47/32A61K47/34A61K33/26A61P7/06
CPCA61K9/5138A61K9/5146A61K33/26A61K49/12A61K49/1854A61K49/1857A61P7/06B82Y5/00A61K47/6933A61K47/6937A61K9/0019A61K9/08A61K9/2009A61K9/2013A61K9/2018A61K9/2054A61K9/2059A61K9/485A61K9/4858A61K9/4866A61K33/32A61K9/51A61K47/32A61K47/34A61K49/18A61K47/58A61K47/6929A61K9/0053C08F292/00
Inventor 侯丽英
Owner 江苏纳菲生物医药科技有限公司
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