45results about How to "Shorten the synthesis process" patented technology

Production of 2-chlorine-5-fluorine-nicotinate and acid is carried out by 2-chlorine-5-fluorine-nicotinate and related carboxylic acid selective dechlorinating, and 2-chlorine-5-fluorine-nicotinate hydrolyzing 2-chlorine-5-fluorine-niacin under the exist of alkaline substances. It can be used for 2-chlorine-5-fluorine-nicotinate and 2-chlorine-5-fluorine-niacin medicine intermediate.

The invention relates to a folic acid coupled targeted ferriferrous oxide/mesoporous silica/copper sulfide nano-composite particle as well as a preparation method and an application thereof. The nano-composite particle consists of Fe3O4@mSiO2 core-shell structural nanoparticles, wherein the core-shell structural nanoparticles take Fe3O4 nanoparticles as cores and mSiO2 as shells, and copper sulfide nanoparticles and folic acid cover the surfaces of the shells; the folic acid is grated on one part of the mesoporous silica (mSiO2) and the copper sulfide particles are loaded on the other part of the mesoporous silica; and polyethylene glycol is grated on the surface of the copper sulfide nanoparticles. Compared with the prior art, the nano-composite particles disclosed by the invention has a broad application prospect in the aspects of nuclear magnetic resonance imaging, drug loading and photothermal therapy; anti-cancer drugs and photothermal reagents can be transmitted to tumor parts in a targeted mode; the nano-composite particle can reduce toxic and side effects on normal tissues and cells, and meanwhile, the nano-composite particle can effectively kill cells, so that a treatment effect is further improved; and moreover, the nano-composite particle is relatively low in preparation condition demand and cost.

The invention discloses a continuous preparation method for semi-aromatic polyamide. The method is characterized by comprising the following steps that: 1 to 50 parts by weight of a catalyst per hour and 1000 to 5000 parts by weight of a semi-aromatic polyamide prepolymer per hour are mixed and then added into a reaction extruder through a main feeding inlet of the extruder; 1 to 10 parts by weight of a molecular weight regulator per hour and 100 to 500 parts by weight of a dispersing material per hour are mixed and then added through an auxiliary feeding inlet; then reactive extrusion is carried out under the conditions of a temperature of 280 to 330 DEG C, a screw rotation speed of 10 to 200 rpm and a vacuum degree of 0.04 to 0.09 MPa; and traction, cooling, granulation and drying are carried out on obtained extrudate so as to obtain semi-aromatic polyamide resin.

The preparation process of porous isomeric clay material includes the steps of: mixing and reacting the dewatered waste organic bentonite and mixed surfactant; adding neutral inorganic precursor to react via stirring; solid-liquid separation to obtain solid, and roasting the solid part to eliminate surfactant and adsorbed organic pollutant. Like similar material, the porous isomeric clay material of the present invention has great specific surface area, homogeneously distributed pores, moderate pore size, high void order degree, and low synthesizing cost.

The invention discloses an 18F-labelled quinazolines irreversible EGFR (epidermal growth factor receptor) positive electron tracer agent, as well as a preparation method and application thereof. The 18F-labelled quinazolines irreversible EGFR positive electron tracer agent has a chemical structure represented by the formula II. The synthesized 18F-labelled small-molecular irreversible EGFR positive electron tracer agent has a clinical value for diagnosing and monitoring a treating effect and particularly plays an important role in pushing individual-based treatment. Furthermore, the invention further provides a one-step method for synthesizing the 18F-labelled small-molecular irreversible EGFR positive electron tracer agent. The method has the characteristics of multiple purposes, high yield, high efficiency, short synthesis time, low cost and the like and can meet a requirement on large-scale production.

The invention discloses a thiocarbamate compound preparation method for preparation of a thiocarbamate flotation agent of sulfide ore. According to the preparation method, corresponding xanthate and amine are adopted as starting materials, water is adopted as a solvent, and a one-step method is adopted to synthesize the corresponding thiocarbamate compound. With the preparation method, the defect of the two-step reaction of the traditional method is overcome, the process is simplified, and a production operation environment is improved. The preparation method has characteristics of simpleness, easy operation, substantial synthesis process shortening, production efficiency improvement, and stable product quality, and provides a simple and feasible method for thiocarbamate flotation agent preparation.

The invention relates to the field of organic compounds and discloses a preparation method of trimethyl gallium. The method comprises the following steps: enabling a gallium salt and methylmagnesium chloride to react in an organic solvent under the protection of an inert gas, and separating the trimethyl gallium from an obtained reaction mixture. The method shortens the process flow, the electrolytic process with higher energy consumption and the synthesis process of a gallium magnesium alloy are avoided, and the production cost of the trimethyl gallium is remarkably lowered.

This invention relates to a method for preparing 2-amino-8-nonenoic acid, especially optically active 2-amino-8-nonenoic acid. The method overcomes the problems of long synthesis route, low yield and expensive chiral catalyst or resolution reagent faced by the present method. The method comprises: attacking chiral pyroglutamate containing protecting groups with Grignard reagent of crotyl bromide to obtain chiral 2-amino-5-oxy-8- nonanoate, reducing to remove carbonyl and obtain chiral or racemized 2-amino-8-nonanoate, and hydrolyzing to obtain optically active 2-amino-8-nonenoic acid. The method in this invention has such advantages as simple route, reasonable process, and high yield, and is suitable for mass production.