45results about How to "Shorten the synthesis process" patented technology

Production of 2-chlorine-5-fluorine-nicotinate and acid is carried out by 2-chlorine-5-fluorine-nicotinate and related carboxylic acid selective dechlorinating, and 2-chlorine-5-fluorine-nicotinate hydrolyzing 2-chlorine-5-fluorine-niacin under the exist of alkaline substances. It can be used for 2-chlorine-5-fluorine-nicotinate and 2-chlorine-5-fluorine-niacin medicine intermediate.

The invention discloses a method for preparing vinyl chloride through catalyzing acetylene and dichloroethane to react. The method comprises the steps: mixing acetylene and dichloroethane steam according to a molar ratio of 1:1-1:4, then introducing into a fixed bed reactor provided with a nitrogen modified catalyst, and carrying out a reaction with the reaction temperature of 180-300 DEG C and the air speed of 20-120 h<-1>. The nitrogen modified catalyst takes active carbon as a carrier, and is loaded with a metal salt compound and a nitrogen-containing compound; based on the total mass of the catalyst, the mass percentage of the metal salt compound is 0.01-10%, and the mass percentage of the nitrogen-containing compound is 0.01-10%. Vinyl chloride prepared by the method has the characteristics of high acetylene conversion rate and high vinyl chloride selectivity; and the nitrogen modified catalyst preparation process adopted in the process method is simple, and the cost is low.

The invention relates to a folic acid coupled targeted ferriferrous oxide / mesoporous silica / copper sulfide nano-composite particle as well as a preparation method and an application thereof. The nano-composite particle consists of Fe3O4@mSiO2 core-shell structural nanoparticles, wherein the core-shell structural nanoparticles take Fe3O4 nanoparticles as cores and mSiO2 as shells, and copper sulfide nanoparticles and folic acid cover the surfaces of the shells; the folic acid is grated on one part of the mesoporous silica (mSiO2) and the copper sulfide particles are loaded on the other part of the mesoporous silica; and polyethylene glycol is grated on the surface of the copper sulfide nanoparticles. Compared with the prior art, the nano-composite particles disclosed by the invention has a broad application prospect in the aspects of nuclear magnetic resonance imaging, drug loading and photothermal therapy; anti-cancer drugs and photothermal reagents can be transmitted to tumor parts in a targeted mode; the nano-composite particle can reduce toxic and side effects on normal tissues and cells, and meanwhile, the nano-composite particle can effectively kill cells, so that a treatment effect is further improved; and moreover, the nano-composite particle is relatively low in preparation condition demand and cost.

The invention discloses a novel use of poly(m-phenylenediamine) as a mercury iron sorbent with low cost and simple synthesis technology, in addition, the poly(m-phenylenediamine) has rapid adsorbing speed for mercury iron at normal temperature, capable of reaching adsorption equilibrium for a short time. Furthermore, the sorbent has a saturated adsorption capacity higher than most of synthetical mercury iron sorbents reported so far. Accordingly, the poly(m-phenylenediamine) sorbent has great latent great value in application, after the cost of material and manufacturing and adsorption properties are comprehensively considered.

The invention discloses a continuous preparation method for semi-aromatic polyamide. The method is characterized by comprising the following steps that: 1 to 50 parts by weight of a catalyst per hour and 1000 to 5000 parts by weight of a semi-aromatic polyamide prepolymer per hour are mixed and then added into a reaction extruder through a main feeding inlet of the extruder; 1 to 10 parts by weight of a molecular weight regulator per hour and 100 to 500 parts by weight of a dispersing material per hour are mixed and then added through an auxiliary feeding inlet; then reactive extrusion is carried out under the conditions of a temperature of 280 to 330 DEG C, a screw rotation speed of 10 to 200 rpm and a vacuum degree of 0.04 to 0.09 MPa; and traction, cooling, granulation and drying are carried out on obtained extrudate so as to obtain semi-aromatic polyamide resin.

The invention is a starch-based high water absorptivity resin preparing method, using starch, acrylic nitricle (AN), and 2-acrylamide-2-methyl prophyl sulfonic acid (AMPS) as raw materials, adopting [Mn(H2P2O7)3]3- as initiator, making graft polymerization and saponification, and fast synthesizing starch-based high water absorptivity resin. It makes graft copolymerization on starch and two kinds of monomer raw materials, making them form multielement compound, the initiator is cheap and the modified process can omit medium washing step and AMPS group is added to be able to obviously shorten the synthesis process and time of the final product, reduce production cost and simultaneously also be able to improve the water-absorbing performance of the final product.

The invention discloses a preparation method of a rare earth doped zinc oxide nanowire for a gas sensor. The zinc oxide nanowire is synthesized under a strong alkali condition by using a chemical solution method; the gas sensor is of a heater-type device structure; an aluminum oxide ceramic tube is used as a carrier and internally provided with a heating wire; a gas sensitive material of the rare earth doped zinc oxide nanowire is coated outside the ceramic tube. The gas sensor can be used for detecting ethanol within different working temperature ranges and is high in response ratio and short in response time. The preparation method of the rare earth doped zinc oxide nanowire is simple; the rare earth doping variety and concentration are easy to control; the obtained rare earth doped zinc oxide nanowire has the advantages such as uniformity in diameter distribution, good stability and the like; the rare earth doped zinc oxide nanowire prepared by the invention can be used for the gas sensor, a solar cell photoanode and the like.

The invention relates to a method for adding a collecting agent in a process of floating bauxite, in particular to a method for preparing and adding a KL collecting agent in a process of positively floating bauxite. The method is characterized by comprising the steps of: with a caustic soda solution, a hydroxylamine hydrochloride solution and methyl benzoate as raw materials, obtaining a mixed solution containing sodium hydroxamate, sodium chloride, methanol and water after carrying out hydroxyl-oximating reaction; and secondly, diluting the prepared mixed solution with water, adding the diluted mixed solution as the collecting agent into the bauxite for floatation. Due to the adoption of the invention, hydroxamate is synthesized through controlling the proper reaction temperature, the synthesized solution containing hydroxyoximate is directly used for preparing the collecting agent, and thus the crystallization separation process is eliminated. The collecting agent prepared from a sodium hydroxamate mixing solution produced by using the method has better application effect in the process of floating the bauxite, and has the advantages of strong collection property, less consumption, good separation effect and wide application prospect.

The preparation process of porous isomeric clay material includes the steps of: mixing and reacting the dewatered waste organic bentonite and mixed surfactant; adding neutral inorganic precursor to react via stirring; solid-liquid separation to obtain solid, and roasting the solid part to eliminate surfactant and adsorbed organic pollutant. Like similar material, the porous isomeric clay material of the present invention has great specific surface area, homogeneously distributed pores, moderate pore size, high void order degree, and low synthesizing cost.

The invention relates to a ceramic positive temperature coefficient (PTC) thermistor of a variable-frequency air conditioner starter and a manufacturing method thereof. The ceramic PTC thermistor belongs to the (Ba1-xCaX) TiO3+TiO2+Y2O3+SiO2+Mn(NO3)2 series. The ceramic PTC thermistor is prepared by 1.022 mol of TiO2, 0.790 to 0.810 mol of BaCO3, 0.179 to 0.185 mol of CaCO3, 0.022 to 0.023 mol ofSiO2, 0.0021 to 0.0022 mol of Y2O3 and 50 mass percent of Mn(NO3)2 solution at the concentration of 0.005 ml per weight percent by a one-step synthesis method. The raw materials are reasonable; the production process is simple; in the product, the Curie temperature is between 125 and 135 DEG C, the voltage resistance is more than AC800V, and the resistivity at room temperature is 190 to 480 Omegacm; and the ceramic PTC thermistor is particularly suitable for the variable-frequency air conditioner starter.

The invention discloses a preparation method for an in situ filled semi-aromatic polyamide composite material. The method is characterized by comprising the following steps: adding 1000 to 5000 parts by weight of a semi-aromatic polyamide prepolymer, 1 to 50 parts by weight of a catalyst, 10 to 5000 parts by weight of a filling material and 1 to 10 parts by weight of a molecular weight regulator into a reaction extruder; carrying out reactive extrusion under the conditions of a temperature of 290 to 330 DEG C, a screw rotation speed of 20 to 200 rpm and a vacuum degree of 0.04 to 0.09 MPa; and then carrying out traction, cooling, granulation and drying on obtained extrudate so as to obtain the in situ filled semi-aromatic polyamide composite material.

The invention discloses an 18F-labelled quinazolines irreversible EGFR (epidermal growth factor receptor) positive electron tracer agent, as well as a preparation method and application thereof. The 18F-labelled quinazolines irreversible EGFR positive electron tracer agent has a chemical structure represented by the formula II. The synthesized 18F-labelled small-molecular irreversible EGFR positive electron tracer agent has a clinical value for diagnosing and monitoring a treating effect and particularly plays an important role in pushing individual-based treatment. Furthermore, the invention further provides a one-step method for synthesizing the 18F-labelled small-molecular irreversible EGFR positive electron tracer agent. The method has the characteristics of multiple purposes, high yield, high efficiency, short synthesis time, low cost and the like and can meet a requirement on large-scale production.

The invention discloses a thiocarbamate compound preparation method for preparation of a thiocarbamate flotation agent of sulfide ore. According to the preparation method, corresponding xanthate and amine are adopted as starting materials, water is adopted as a solvent, and a one-step method is adopted to synthesize the corresponding thiocarbamate compound. With the preparation method, the defect of the two-step reaction of the traditional method is overcome, the process is simplified, and a production operation environment is improved. The preparation method has characteristics of simpleness, easy operation, substantial synthesis process shortening, production efficiency improvement, and stable product quality, and provides a simple and feasible method for thiocarbamate flotation agent preparation.

The invention relates to a preparation method of a beta-cyclodextrin modified starch material, and an adsorption property of the beta-cyclodextrin modified starch material on a dye. The process technology is simpler and novel, the cyclodextrin content of the obtained cyclodextrin modified starch material is higher, an adsorption effect on the dye is better, the removal rate of the dye can reach up to 86.0618 percent maximally, and the adsorption effect of the beta-cyclodextrin modified starch material is superior to the adsorption effect of a common adsorption agent such as corn starch, activated carbon and zeolite. The cyclodextrin modified starch material is naturally degradable, free of toxic and side effects, green and environment-friendly, high in safety and the like.

This invention relates to a method for preparing 2-amino-8-nonenoic acid, especially optically active 2-amino-8-nonenoic acid. The method overcomes the problems of long synthesis route, low yield and expensive chiral catalyst or resolution reagent faced by the present method. The method comprises: attacking chiral pyroglutamate containing protecting groups with Grignard reagent of crotyl bromide to obtain chiral 2-amino-5-oxy-8- nonanoate, reducing to remove carbonyl and obtain chiral or racemized 2-amino-8-nonanoate, and hydrolyzing to obtain optically active 2-amino-8-nonenoic acid. The method in this invention has such advantages as simple route, reasonable process, and high yield, and is suitable for mass production.

The invention discloses a continuous preparation method for semi-aromatic polyamide. The method is characterized by comprising the following steps that: 1 to 50 parts by weight of a catalyst per hour and 1000 to 5000 parts by weight of a semi-aromatic polyamide prepolymer per hour are mixed and then added into a reaction extruder through a main feeding inlet of the extruder; 1 to 10 parts by weight of a molecular weight regulator per hour and 100 to 500 parts by weight of a dispersing material per hour are mixed and then added through an auxiliary feeding inlet; then reactive extrusion is carried out under the conditions of a temperature of 280 to 330 DEG C, a screw rotation speed of 10 to 200 rpm and a vacuum degree of 0.04 to 0.09 MPa; and traction, cooling, granulation and drying are carried out on obtained extrudate so as to obtain semi-aromatic polyamide resin.

The invention discloses a macromolecule-metallic oxide compound. The macromolecule-metallic oxide compound comprises a metallic oxide particle located in the center and a macromolecule modified on thesurface of the metallic oxide particle, the macromolecule has a functional group capable of being bonded with a metal in the metallic oxide, and the density of a binding site of the polymer and the surface of the metallic oxide is more than 2 binding sites per square nanometer. The invention further discloses a preparation method of the macromolecule-metallic oxide compound and application of themacromolecule-metallic oxide compound as a nuclear magnetic resonance contrast medium and an iron supplement agent. The disclosed macromolecule-metallic oxide compound greatly prolongs the circulation time of the macromolecule-metallic oxide compound in a body and effectively overcomes the defect that the existing contrast medium causes the hypersensitivity, and as the compound has superparamagnetism and has the function of participating in iron metabolism, the macromolecule-metallic oxide compound can be applied as the nuclear magnetic resonance contrast medium and the iron supplement agentused for treating iron-deficiency anaemia.

The present invention discloses a preparation method for an anatase type bentonite-based porous TiO2 nanometer material. The preparation method is that the organic bentonite after dehydration and drying or the organic bentonite abandoned after wastewater treatment is added with the mixture of amine and titanate or only added with titanate; then after well mixing and centrifuging, the supernate isabandoned and the solid part left will be removed from surfactant and organic materials through drying and high-temperature calcinations, thus the porous TiO2 nanometer material is obtained. The material prepared by the invention is of large specific surface area, smaller grain size, single particle size and uniform pore distribution, wherein, the aperture ranges between micropore and mesopore andthe pores are in high sequence degree. The material is mainly anatase type and is provided with relatively high catalytic activity, which can be applied to the indoor organic pollutant purification field. At the same time, the present invention provides a very good solution to the ultimate disposition of abandoned organobentonite, and makes good use of the abandoned organobentonite after wastewater treatment to achieve the treatment of a waste with another waste. The preparation method is of low energy consumption, simple preparation process, optimal pH control and no need of acid, which is suitable for large-scale engineering applications.

The invention is a starch-based high water absorptivity resin preparing method, using starch, acrylic nitricle (AN), and 2-acrylamide-2-methyl prophyl sulfonic acid (AMPS) as raw materials, adopting [Mn(H2P2O7)3]3- as initiator, making graft polymerization and saponification, and fast synthesizing starch-based high water absorptivity resin. It makes graft copolymerization on starch and two kinds of monomer raw materials, making them form multielement compound, the initiator is cheap and the modified process can omit medium washing step and AMPS group is added to be able to obviously shorten the synthesis process and time of the final product, reduce production cost and simultaneously also be able to improve the water-absorbing performance of the final product.

The invention relates to a method for synthesizing a sulfide solid electrolyte. The method comprises the following steps of: weighing raw materials according to a composition proportion of a sulfide solid electrolytic tank in a dry argon atmosphere, and performing plasma ball milling in a ball milling tank, wherein the raw materials comprise pure lithium, powdered sulfur and phosphorus pentasulfide; under the protection of a dry inert atmosphere, performing heat treatment on the powder obtained after ball milling in the step 1 at the temperature of 350-550 DEG C for 1-5 hours, and performing rapid shock cooling after heat treatment; and crushing and granulating the product subjected to heat treatment in the step 2 to obtain the sulfide electrolyte. The method does not need to adopt a lithium sulfide raw material, directly uses the pure lithium and sulfur powder which are low in price as raw materials, and adopts a plasma ball milling technology, so that the pure lithium, the sulfur powder and phosphorus pentasulfide raw materials can directly form a solid electrolyte precursor; and the performance of the synthesized solid electrolyte is equivalent to that of a solid electrolyte obtained by adopting an existing method.

The present invention relates to preparation process of optically active long chain N-Boc-amino acid with end olefinic bond, and the preparation process is superior to available process, which has long path, low yield and expensive chiral reagent. The preparation process includes attacking metylene radical of azirane derivative selectively with olefin halide Grignard reagent with end olefinic bond and opening ring to obtain beta-amino alcohol with protecting group, eliminating protecting hydroxyl group to obtain beta-amino alcohol, and oxidizing to obtain optically active long chain N-Boc-amino acid with end olefinic bond. The present invention is used in preparing anti-HCV medicine BILN2061.

The invention discloses a method for preparing CL-20 through a two-step method, and belongs to the technical field of energetic materials. The method includes the steps of firstly, adding a sulfamatewater solution and a 40% glyoxal water solution into a container, conducting the condensation reaction at a certain temperature, and then conducting filtering and drying to obtain white powder HSIW; secondly, conducting nitration reaction on the HSIW obtained in the first step through a nitrating agent, pouring nitration liquid into icy water, and conducting filtering, washing and drying to obtaina product containing CL-20, wherein the yield of the CL-20 can reach 1.78% at most. By means of the method, sulfamate replaces benzylamine, and the raw material cost is reduced; no catalytic hydrogenolysis is needed, and cost is reduced; the preparing process of the CL-20 is simplified, and the synthesis cycle of the CL-20 is shortened.

Production of 2-chlorine-5-fluorine-nicotinate and acid is carried out by 2-chlorine-5-fluorine-nicotinate and related carboxylic acid selective dechlorinating, and 2-chlorine-5-fluorine-nicotinate hydrolyzing 2-chlorine-5-fluorine-niacin under the exist of alkaline substances. It can be used for 2-chlorine-5-fluorine-nicotinate and 2-chlorine-5-fluorine-niacin medicine intermediate.

The invention discloses a method for preparing a Co3O4 nano material by a Co2O3 powder, comprising the following steps: taking the Co2O3 powder as a precursor, wherein, if deionized water and alcohol are taken as solvents, the volume ratio of the deionized water to the alcohol of absolute alcohol is 9:1 to 0:10; or when the water solution of glucose is taken as the solvent, the mass fraction of the glucose is between 5-30 percent; mixing and stirring 0.1-0.2mol / L Co2O3 powder and deionized water and alcohol or glucose aqueous solution solvent to form a uniform mixed material, wherein the alcohol may be ethanol, ethylene glycol or glycerol; putting the mixed material in a container, then putting the container in a constant temperature cabinet, raising the temperature at a speed of 8.5-11.5 DEG C / min, and heating the mixed material within the temperature range of 120-160 DEG C for 6-24h; taking the container out for cooling to the room temperature; alternately washing a synthetic product by the deionized water and the absolute alcohol, and drying at low temperature to obtain the Co3O4 nano material. The Co3O4 nano material prepared by the method has easily controlled shape and granularity, high purity, good crystallinity and environment-friendly production process.

The invention discloses a preparation method of a diazonium photosensitizer, which comprises the following steps: 1) mixing concentrated sulfuric acid and phosphoric acid according to a proper ratio to obtain a mixed acid, cooling, and slowly adding a proper amount of p-aminodiphenylamine diazonium sulfate (VRT) which is a wet product; wherein the temperature is controlled to be 20-40 DEG C when the p-aminodiphenylamine diazonium sulfate is added; 2) slowly adding a proper amount of paraformaldehyde after the dissolution in the step 1) is finished, and reacting at the temperature of below 40 DEG C until the reaction is complete; 3) dissolving a reaction solution completely reacted in the step 2) in water, adding a proper amount of a chlorine salt, and separating out a yellow precipitate; and 4) filtering, and drying the yellow precipitate to obtain the product. According to the preparation method disclosed by the invention, reaction with paraformaldehyde is carried out in the mixed acid, the reaction temperature can be effectively increased, the direct damage effect of the concentrated sulfuric acid on the raw materials is reduced, the reaction can be carried out at a relatively high temperature which is easier to control, the weight of the synthesized photosensitizer required for photoresist mixing is reduced to 90%, and the cost is saved.

The invention relates to a ceramic positive temperature coefficient (PTC) thermistor of a variable-frequency air conditioner starter and a manufacturing method thereof. The ceramic PTC thermistor belongs to the (Ba1-xCaX) TiO3+TiO2+Y2O3+SiO2+Mn(NO3)2 series. The ceramic PTC thermistor is prepared by 1.022 mol of TiO2, 0.790 to 0.810 mol of BaCO3, 0.179 to 0.185 mol of CaCO3, 0.022 to 0.023 mol of SiO2, 0.0021 to 0.0022 mol of Y2O3 and 50 mass percent of Mn(NO3)2 solution at the concentration of 0.005 ml per weight percent by a one-step synthesis method. The raw materials are reasonable; the production process is simple; in the product, the Curie temperature is between 125 and 135 DEG C, the voltage resistance is more than AC800V, and the resistivity at room temperature is 190 to 480 Omega cm; and the ceramic PTC thermistor is particularly suitable for the variable-frequency air conditioner starter.

The invention discloses an electrochemical synthesis method of a beta-acetamido carbonyl compound, and belongs to the technical field of chemical engineering. A green electrochemical synthesis mode is adopted to realize oxidative coupling of alkenyl amide, formate and aldehyde compounds through an electrochemical method, so the beta-acetamido carbonyl compound is simply, efficiently and practically prepared.The electrochemical method does not need to add additional oxidizing agents and catalysts, the method improves the raw material utilization rate of the whole process, reduces the production cost and three-waste pollution generated in the production process, is more green and environment-friendly, and has wide industrial application prospects and economic and practical values.