Porous biological scaffold for preventing internal-fixation-material-removed refracture, and preparation thereof
A bio-scaffold and bio-glass technology, which is applied in the field of porous bio-scaffold and its preparation, can solve the problem of unfavorable bone replacement and bone reconstruction material growth, the difficulty of precisely controlling the shape and particle size of pores, and the inability of bone fibers to pass through completely. etc. to achieve excellent biological activity, good biocompatibility and good plasticity
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[0055] The preparation method of described bioglass specifically comprises the steps:
[0056] Using water, ethanol or a mixture of ethanol and water as a solvent, mix phytic acid, tetraethyl orthosilicate and calcium nitrate or calcium chloride to prepare a gel precursor sol solution; prepare the gel precursor sol solution at room temperature Put it down until it gels; age at 60°C, then take it out and bake it in an oven to evaporate all the solvents, cool down to room temperature, then raise the temperature from room temperature to 300-400°C, dry the dried The glue is sintered at a constant temperature of 300-400°C for at least 10 minutes and then cooled naturally to obtain bioglass; wherein: the addition of phytic acid, tetraethyl orthosilicate and calcium nitrate or calcium chloride is through the bioglass. P 2 o 5 , SiO 2 And the molar percentage of CaO to reflect.
[0057] Optionally, during the preparation of the bioglass, sodium salts, zinc salts, and strontium sal...
Embodiment 1
[0066] Embodiment 1 has the preparation of the BP-14 / Gel of porous scaffold structure
[0067] The gelatin was swollen in water at room temperature, and then heated and dissolved at 40° C. to obtain a uniform gelatin solution with a concentration of 20 wt%. Add bioglass BP-14 into the gelatin solution (the molar ratio of bioglass BP-14 and gelatin is 1:1), stir at 40°C for 8h, and mix thoroughly. Pour the uniformly mixed liquid into a polyethylene mold and age for 24 hours. After the aging is completed, place it in a -20°C refrigerator for 48 hours. Freeze-dry the frozen sample at -54°C for 2-3 days . Soak the freeze-dried sample in 1wt% glutaraldehyde solution for 24 hours to fully cross-link. After the cross-linking is completed, take out the sample and fully wash it with ultrapure water, and soak it in water for 24 hours. Change the water every 6-8 hours , to ensure that unreacted glutaraldehyde can be completely removed. Finally, the sample soaked in water was freeze-dr...
Embodiment 2
[0076] Embodiment 2 has the preparation of the BP-65 / Gel of porous scaffold structure
[0077] The preparation method of the BP-65 / Gel with a porous scaffold structure is the same as in Example 1, the only difference is that the bioglass uses BP-65.
[0078] figure 2 (c) is a scanning electron microscope image of BP-65 / Gel with a porous scaffold structure prepared in Example 2 of the present invention. It can be seen from the figure that the BP-65 / Gel with a porous scaffold structure prepared in this embodiment can be clearly observed The large pores penetrate the structure, indicating that it has connected channels; the porosity of the BP-65 / Gel is 85.1±2.4%, and the pore size is 50-400 μm.
[0079] image 3 (b) is the distribution diagram of BP in BP-65 / Gel with a porous scaffold structure prepared in Example 2 of the present invention. It can be seen from the figure that the BP in BP-65 / Gel with a porous scaffold structure prepared in this embodiment is The particles ar...
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Abstract
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