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Acne removing and oil controlling microemulsion gel as well as preparation method and application thereof

A technology of gel and oil microemulsion, which is applied in the fields of medicine and cosmetics, can solve problems such as the difficulty in forming cosmetic compositions, and achieve the effects of increasing the transdermal penetration rate, improving bioavailability, and prolonging the action time

Inactive Publication Date: 2018-06-15
连云港本草美汇医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The results show that it has a certain bactericidal rate against Propionibacterium acnes, but it uses a variety of plant extracts, making it difficult to form a stable cosmetic composition

Method used

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  • Acne removing and oil controlling microemulsion gel as well as preparation method and application thereof
  • Acne removing and oil controlling microemulsion gel as well as preparation method and application thereof
  • Acne removing and oil controlling microemulsion gel as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] The selection of embodiment 1 microemulsion surfactant and co-surfactant

[0035] The HLB value of the surfactant for preparing O / W microemulsion is 8-18. The present invention screens and adopts Tween 80 and polyoxyethylene castor oil respectively as surfactant, and screens dehydrated alcohol, 1,2-propanediol, glycerin, polyethylene glycol-400 as co-surfactant, surfactant and co-surfactant Active agents are mixed in a mass ratio of 3:1 as a mixed surfactant. Isopropyl myristate is the oil phase, the mixed surface activity is 9:1, 8:2, 7:3, 6:4, 5:5, 4:6, 3:7, 2:8, 1:9 (w / w) mixing to carry out the screening experiment, adding water dropwise at room temperature, taking the critical point of the system from clear to turbid, and from turbid to clear as the judgment standard, to screen suitable surfactants (note: "+" means that it can form Transparent microemulsion; "one" means turbid, unable to form microemulsion). The experimental results show that: when isopropyl myr...

Embodiment 2

[0038] The screening of embodiment 2 gel matrix

[0039] The present invention takes the appearance of the gel in the "Chinese Pharmacopoeia" as an index, which should be uniform, delicate, and keep the gel shape without drying or liquefaction at normal temperature, and obtain the best matrix material through screening. Add carbomer 940, methylcellulose, hydroxypropylmethylcellulose, sodium hydroxymethylcellulose, chitosan, and sodium alginate to blank microemulsion, and swell at (40±1)°C , to prepare a gel (see Table 2). It can be obtained from the table that Carbomer 940 gel matrix is ​​better than other gel matrix. Accordingly, Carbomer 940 gel matrix is ​​preferred in the present invention.

[0040] Table 2 Phenomena of adding different gel matrices

[0041]

[0042]

Embodiment 3

[0043] Embodiment 3 microemulsion gel transdermal test in vitro

[0044] About 20 g of healthy male mice were taken, the hair on the abdominal skin was carefully cut off with scissors, the neck was cut off, and the abdominal skin was peeled off. Spread the peeled skin on a glass plate with the cuticle down, carefully remove the subcutaneous fat and adhesions with a single-back blade, then rinse it with normal saline repeatedly, cut it into an appropriate size, and check the integrity of the skin. Before each experiment, check the integrity of the mouse skin without any damage.

[0045] Fix the skin between the upper and lower chambers of the diffusion cell, with the stratum corneum facing upward, the receiving solution is physiological saline (the volume of the receiving cell is 7mL), and the supply cell is filled with the samples to be tested (salicylic acid, nicotinamide, ascorbic acid, red Bisabolol) 1g, cover the pool mouth with plastic wrap. Place the device in a consta...

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Abstract

The invention discloses an acne removing and oil controlling microemulsion gel and a preparation method thereof. The microemulsion gel is prepared from the following raw materials: 0.1-2 parts of salicylic acid, 0.1-3 parts of nicotinamide, 0.1-3 parts of ascorbic acid, 0.01-0.1 part of bisabolol, 0.01-0.2 part of zinc pyrrolidonecarboxylate, 0.01-0.5 parts of panthenol, 0.01-0.2 part of dipotassium glycyrrhizinate, 1-20 parts of an oil phase, 1-15 parts of a surfactant, 1-10 parts of a co-surfactant, 0.1-10 parts of a gel matrix material, 0.1-5 parts of a pH regulator, 0.1-1 part of a preservative and deionized water. The microemulsion gel provided by the invention is administered to skin, can increase a transdermal permeation rate, promotes transdermal absorption of multiple active ingredients, can achieve purposes of sustained release and long acting, has high product stability and good acne removing effect, and is simple in preparation process and suitable for industrial mass production.

Description

technical field [0001] The invention belongs to the technical fields of medicine and cosmetics, and in particular relates to an acne-removing and oil-controlling microemulsion gel and a preparation method thereof. Background technique [0002] The degree of absorption of active ingredients in cosmetics through the skin determines its efficacy, and any cosmetics must pass through a suitable carrier to exert its due effect. That is to say, the composition and properties of the cosmetic matrix directly affect the absorption of its active ingredients. [0003] Microemulsion (ME) is a liquid state composed of water phase, oil phase, surfactant and co-surfactant, with clear and transparent appearance, droplet size less than 100nm, and very stable thermodynamics and kinetics. system. The particle size of microemulsion droplets is extremely small, and can be freely dispersed in another liquid to form a colloidal dispersion system. The shape of the emulsion droplets is mostly spher...

Claims

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Application Information

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IPC IPC(8): A61K9/107A61K9/06A61K33/30A61P17/10A61K8/365A61K8/67A61K8/34A61K8/49A61K8/63A61Q19/00A61K31/60A61K31/455A61K31/375A61K31/045A61K31/164A61K31/704
CPCA61K8/34A61K8/365A61K8/4913A61K8/63A61K8/673A61K8/675A61K8/676A61K9/06A61K9/1075A61K31/045A61K31/164A61K31/375A61K31/455A61K31/60A61K31/704A61K33/30A61K47/44A61Q19/008
Inventor 秦昆明石芸
Owner 连云港本草美汇医药科技有限公司
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