A kind of preparation method of integrated small diameter artificial vascular stent

A technology for artificial blood vessels and vascular stents, applied in stents, textiles, papermaking, filament/thread forming, etc., can solve problems such as vascular intimal hyperplasia and easy formation of thrombus, and achieve good biocompatibility, low cost, and high efficiency high effect

Active Publication Date: 2020-12-01
云帆(天津)仪器有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The reason is that when a small-caliber artificial vascular stent is implanted in the body, it is very easy to form a thrombus and lead to vascular intimal hyperplasia.

Method used

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  • A kind of preparation method of integrated small diameter artificial vascular stent
  • A kind of preparation method of integrated small diameter artificial vascular stent

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0072] Step 1, prepare spinning solution

[0073] At room temperature, the silk fibroin and the sulfated silk fibroin were blended and dissolved in hexafluoroisopropanol, dissolved and stirred by a constant temperature magnetic stirrer until the solution was transparent, and a polymer A solution with a mass fraction of 7% was obtained; The lactone was dissolved in chloroform / N,N-dimethylformamide (7:3), dissolved and stirred by a constant temperature magnetic stirrer until the solution was transparent, and a polymer B solution with a mass fraction of 10% was obtained.

[0074] Step 2, preparation of vascular inner layer fibrous membrane

[0075] Under the environmental conditions of a temperature of 20° C. and a relative humidity of 45%, the prepared solution A was added to the syringe, and the distance between the two receiving plates was set at 3 cm. Apply a layer of lubricant (PEG) on the receiving roller before spinning, turn on the DC high voltage generator, adjust the s...

Embodiment 2

[0084] Step 1, prepare spinning solution

[0085] At room temperature, dissolve polyglycolic acid in hexafluoroisopropanol, pass through a constant temperature magnetic stirrer, dissolve and stir until the solution is transparent, and obtain a polymer A solution with a mass fraction of 8%; dissolve polyurethane in dichloromethane, pass through a constant temperature magnetic force Stirrer, dissolve and stir until the solution is transparent to obtain a polymer B solution with a mass fraction of 11%.

[0086] Step 2, preparation of vascular inner layer fibrous membrane

[0087] Under the environmental conditions of a temperature of 22° C. and a relative humidity of 55%, the prepared solution A was added to the syringe, and the distance between the two receiving plates was set at 3.5 cm. Apply a layer of lubricant (PEG) on the receiving roll before spinning, turn on the DC high voltage generator, adjust the spinning voltage to 20kV, adjust the spinning distance to 150mm, and co...

Embodiment 3

[0096] Step 1, prepare spinning solution

[0097] At room temperature, chitosan and collagen are blended and dissolved in trifluoroacetic acid, and dissolved and stirred until the solution is transparent by a constant temperature magnetic stirrer to obtain a polymer A solution with a mass fraction of 9%; ester) was dissolved in acetone, passed through a constant temperature magnetic stirrer, dissolved and stirred until the solution was transparent, and a polymer B solution with a mass fraction of 12% was obtained.

[0098] Step 2, preparation of vascular inner layer fibrous membrane

[0099] Under the environmental conditions of a temperature of 30° C. and a relative humidity of 60%, the prepared solution A was added to the syringe, and the distance between the two receiving plates was set at 5 cm. Apply a layer of lubricant (PEG) on the receiving roll before spinning, turn on the DC high voltage generator, adjust the spinning voltage to 30kV, adjust the spinning distance to ...

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Abstract

The invention discloses a device for electrospinning an integrated small-bore artificial vascular stent. The device comprises a spinning device, a receiving device and a vascular stent molding device;the vascular stent molding device comprises a fiber winding device and a winding control device, wherein the fiber winding device is used for winding a fiber received by the receiving device into a cylinder shape; the winding control device is used for controlling the fiber winding device to move axially and rotate circumferentially to form a nanofiber tube, the nanofiber tube is subjected to rinsing and receiving roller removing to obtain the integrated small-bore artificial vascular stent. The invention further discloses a method for preparing the integrated small-bore artificial vascular stent by adopting the device. The device and method for electrospinning the integrated small-bore artificial vascular stent have the advantages that the device structure is simple, the cost is low, theproduction process is operated easily, and the efficiency is high; when the small-bore artificial vascular stent is prepared, the inner diameter of the receiving roller can be controlled by adjustingthe diameter of the cross section of the receiving roller; the prepared small-bore artificial vascular stent by adopting the device has the characteristics of large strength, high porosity, good biocompatibility and the like.

Description

technical field [0001] The invention belongs to the technical field of electrospinning, and relates to an electrospinning integrated small-diameter artificial vascular stent device, and also relates to a method for preparing an integrated small-diameter artificial vascular stent by using the above-mentioned device. Background technique [0002] Human blood vessels consist of three layers: intima, media and adventitia. Each layer is composed of different cells, and the inner and outer layers should have good biocompatibility and hemocompatibility in contact with blood; the middle layer needs to maintain the vascular structure and bear the pressure of blood vessels, so it should have excellent mechanics performance. [0003] In modern society, with the accelerated pace of life and irregular diet, cardiovascular disease has become a major killer threatening human health and an important cause of high human mortality. Vascular reconstruction surgery is an effective method for ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): D04H1/728D04H1/76D01D5/00
CPCD01D5/0076D04H1/728D04H1/76D10B2509/06
Inventor 刘呈坤吴红李博昱毛雪孙润军陈美玉
Owner 云帆(天津)仪器有限公司
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