Pharmaceutical composition with function of effectively promoting sleep

Abstract

The invention belongs to pharmaceutical compositions, and in particular relates to a pharmaceutical composition with a function of effectively promoting sleep. The pharmaceutical composition is prepared from the following raw materials in parts by weight: 4-6 parts of melatonin, 0.2-0.8 part of vitamin B6, 6-10 parts of herba euphorbiae lunulata extract, 0.08-0.1 part of epimedium herb aqueous extract and 1.2-1.8 parts of medium-chain fatty acid triglyceride. Compared with the prior art, the pharmaceutical composition provided by the invention has the advantages that the medicine raw materialsof the pharmaceutical composition are easy to obtain and scientific and reasonable in combination; the epimedium herb extract and the herba euphorbiae lunulata extract are used for regulating the balance of a cerebral cortex excitement and inhibition process, and have a certain inhibiting effect on the different parts of the nerve center; the medium-chain fatty acid triglyceride can help to enhance the effect of the melatonin; tablets prepared from the pharmaceutical composition are simple in preparation method, have no toxic and side effects, can be safely used, have a better hypnotic effectafter being taken, and are free from an after effect.

Description

technical field [0001] The invention belongs to pharmaceutical compositions, in particular to a pharmaceutical composition capable of effectively promoting sleep. Background technique [0002] Insomnia is a kind of disease characterized by the inability to obtain normal sleep due to mental disorders or restlessness. It is mainly manifested in the lack of sleep time and depth and the inability to eliminate fatigue, restore physical strength and memory. In mild cases, it is difficult to fall asleep or sleep soundly. Waking up from time to time, or being unable to sleep again after waking up, and severe cases of insomnia all night. Western medicine usually uses oryzanol, Acanthopanax and other drugs that nourish the brain nerves in the treatment of mild cases. These drugs are prone to addiction or side effects, and it is difficult to fundamentally improve sleep. Compared with western medicines, tranquilizing traditional Chinese medicines and their preparations are safer and mor...

AI Technical Summary

Problems solved by technology

[0002] Insomnia is a kind of disease characterized by the inability to obtain normal sleep due to mental disorders or restlessness. It is mainly manifested in the lack of sleep time and depth and the inability to eliminate fatigue, restore physical strength and memory. In mild cases, it is difficult to fall asleep or sleep soundly. Waking up from time to time, or being unable to sleep again after waking up, and severe cases of insomnia all night. Western medicine usually uses oryzanol, Acanthopanax and other drugs that nourish the brain nerves in the treatment of mild cases. These drugs are prone to addiction or side effects, and it is difficult to fundamentally improve sleep. Compared with western medicines, tranquilizing traditional Chinese medicines and their preparations are safer and more reliable, with less toxic and side effects, but the action time is slower

[0003] Melatonin, whose chemical name is N-acetyl-5-methoxytryptamine, plays an important role in regulating human growth and development, reproduction and metabolism, and has the effects of sedative hypnosis, enhancing immune function, prolonging life and inhibiting tumors , the dosage forms of domestic and foreign marketed varieties include ordinary tablets, capsules, and general medicines. Ordinary tablets and capsules have the characteristics of fast onset of action, but short maintenance time. General sustained-release tablets have the characteristics of long maintenance time, but slow onset of action. , both of which can not meet the needs of patients very well. The application document with the application number 021338876 discloses a double-layer tablet composed of an immediate-release layer and a sustained-release layer with melatonin as the main raw material. The composition of the release layer includes 1-5% of melatonin, 3-15% of vitamin B6, 10-70% of lactose, 10-70% of pregelatinized starch, 1% of hypromellose, and 0.3% of magnesium stearate. -2%, silicon dioxide 1.0-3.0%; the composition of the sustained-release layer includes: melatonin 2-6%, hypromellose 15-60%, stearic acid 15-65%, polyethylene glycol 10000 10-30%, magnesium stearate 1.0-5.0%, through the double-layer tablet of quick release and slow release, this product has the effect of rapid hypnosis and effective sleep time prolongation, which can relatively make up for the existing market. However, there are many raw materials and cumbersome preparation methods. If melatonin is not consumed properly, it will cause hypothermia, release too much prolactin, cause infertility, and reduce male libido. Melanin's sleep-promoting product undergoes further research