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Method for simultaneously determining 19 sun-screening agents in cosmetics

A technology of sunscreen and cosmetics, applied in the field of analysis and detection, can solve the problems of corrosion, experimenters harming the environment, pollution, etc., and achieve good reproducibility and durability, simple sample processing method, simple and environmentally friendly method Effect

Pending Publication Date: 2018-11-13
青海省药品检验检测院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

According to the "Specifications", there are 25 kinds of chemical sunscreens that can be used within the limited range, but only 19 kinds of sunscreens have listed detection methods, and they are 5 different groups of HPLC methods, including the restricted component phenylbenzene The determination of 15 components such as imidazole sulfonic acid, the determination of 3 components of diethylamino hydroxybenzoyl hexyl benzoate, diethylhexyl butyramide triazone and benzylidene camphor sulfonic acid respectively, and banned The detection method of the component benzophenone-2 is time-consuming and labor-intensive, and the operability is not good
After experimental research, the determination methods of 15 components such as phenylbenzimidazole sulfonic acid in the "Specifications" have certain limitations in actual inspection work, not only for many polyetheretherketone (PEEK) component materials of reversed-phase liquid chromatography It is corrosive, and the repeatability of retention time will decrease when running in large batches. It is also harmful to experimenters and pollutes the environment.

Method used

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  • Method for simultaneously determining 19 sun-screening agents in cosmetics
  • Method for simultaneously determining 19 sun-screening agents in cosmetics
  • Method for simultaneously determining 19 sun-screening agents in cosmetics

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0051] A method for simultaneous determination of isoamyl p-methoxycinnamate, ethylhexyl triazone, bis-ethylhexylphenol methoxyphenyl triazine, diethylhexylbutyrylamide triazone, benzophenone in cosmetics -3, Benzophenone-5, Benzophenone-2, PABA Ethylhexyl Ester, Benzylidene Camphor Sulfonic Acid, Diethylamine Hydroxybenzoyl Hexyl Benzoate, p-Aminobenzoic Acid, Phenylbenzimidazole Sulfonic acid, 4-methylbenzylidene camphor, butylmethoxydibenzoylmethane, octocrylene, ethylhexyl methoxycinnamate, ethylhexyl salicylate, homosalate and Methylbis-benzotriazolyltetramethylbutylphenol and other 19 sunscreen methods:

[0052] Methanol, isopropanol, tetrahydrofuran, formic acid and sodium hydroxide used are chromatographically pure, wherein the purity of formic acid and dimethyl sulfoxide is more than or equal to 99%, and the purity of formic acid is more than or equal to 99%.

[0053] Preparation of single-standard mother liquor: accurately weigh phenyl benzimidazole sulfonic acid an...

Embodiment 2

[0065] Linear range and limit of detection (LOD), limit of quantitation (LOQ):

[0066] Take a series of standard solutions for measurement and analysis, and perform linear regression analysis with the sunscreen concentration as the abscissa and the peak area as the ordinate.

[0067] 19 kinds of sunscreen mixed standard plus matrix solution were prepared from sunscreen-free facial cleanser products and diluted step by step to determine the detection limit and quantification limit of this method. Injection volumes were used as LOD and LOQ. The results are shown in Table 3.

[0068] Table 3 Linear results and LOD, LOQ of 19 sunscreens

[0069]

[0070] The measurement results showed that all the sunscreens were within the injection range, and the injection concentration and the chromatographic peak area had a good linear relationship, and the correlation coefficients were all greater than 0.99.

Embodiment 3

[0072] Recovery and precision determination:

[0073] Choose one of four different matrix cosmetics without sunscreen, such as water, lotion, cream, and face cleanser. Take 9 parts of each, and add low (60%), medium (100%), and high (140%) three For each concentration gradient sample, three parallel samples were made, and the sample was processed and measured according to the method established in this study, and the recovery rate and RSD were calculated. The results are shown in Table 4.

[0074] Table 4 Concentration of mixed standard stock solution (n=9)

[0075]

[0076] The sample recovery of each component in different matrices ranges from 96.3% to 104.3%, and the RSD ranges from 0.82 to 2.45%, indicating that the method has good accuracy and the selected extraction method can be adapted to water, lotion, cream and cleansing. Base cosmetics.

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Abstract

The invention relates to the technical field of analysis and detection, in particular to a method for simultaneously determining 19 sun-screening agents in cosmetics. The method comprises the steps ofpreparation of a mono-standard mother solution, preparation of mixed standard solutions, preparation of a series of mixed standard solutions, preparation of test product solutions and liquid chromatography determination. Response values of a series of mixed standard solutions and the test product solutions are in a linear range of instrument detection, are qualitative according to peak retentiontime and are quantitative according to peak area. The sample processing method is simple and effective. Simultaneous separation and detection of 19 sun-screening agents on a C18 chromatographic columnare achieved. The method is simple, convenient, environmentally friendly, high in accuracy and good in repeatability and durability.

Description

technical field [0001] The invention relates to the technical field of analysis and detection, in particular to a method for simultaneously measuring 19 sunscreens in cosmetics. Background technique [0002] Industrial pollution has caused serious damage to the ozone layer in the atmosphere, increasing the amount of ultraviolet rays entering the ground from the sun. Excessive ultraviolet radiation will cause serious damage to human skin. Medium-wave ultraviolet UVB (280-320nm) causes skin sunburn and redness in a short period of time; long-wave ultraviolet UVA (320-400nm) has a strong penetrating ability, can penetrate deep into the tissues below the dermis, destroy collagen, and accelerate the formation of melanin. can cause skin cancer. [0003] Sunscreens can protect the skin from ultraviolet rays and are often added to cosmetics to make sunscreen cosmetics. Sunscreens can be divided into physical sunscreens and chemical sunscreens. Physical sunscreens block ultraviolet...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/02
CPCG01N30/02
Inventor 韩晓萍李亚楠王启林肖瑞娜李玉丽唐启奎李镇冰董海彦骆桂法海平
Owner 青海省药品检验检测院
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