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Calcium phosphate/bioactive glass bone repair bracket and preparation method thereof

A technology of bioactive glass and calcium phosphate bone, which is applied in the field of bone repair materials, can solve problems such as the inability to manufacture bone repair scaffolds, the inability to control the pore size, and the toxic and side effects of pore-forming agents, so as to avoid excessive coagulation time and excellent biophase Capacitance, effect of shortening setting time

Active Publication Date: 2019-01-04
GUANGZHOU RAINHOME PHARM&TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The preparation method of traditional porous scaffold materials is manual operation with poor reproducibility; the added pore-forming agent has potential toxic side effects, poor pore connectivity, or the pore size cannot be controlled, and it is impossible to manufacture bone repair scaffolds with complex shapes

Method used

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  • Calcium phosphate/bioactive glass bone repair bracket and preparation method thereof

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Experimental program
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Effect test

Embodiment 1

[0043] A preparation method of calcium phosphate / bioactive glass bone repair bracket, comprising the following steps:

[0044] (1) The bone cement solid phase powder and bioactive glass are mixed in a mass ratio of 1:0.04 to obtain a mixed powder; the solid phase powder includes polyethylene glycol, tetracalcium phosphate and calcium dihydrogen phosphate, and the solid phase powder The massfraction of polyethylene glycol in the medium is 0.01%;

[0045] (2) Mix the mixed solid phase powder and the solidified liquid according to the solid-to-liquid ratio of 1g:0.45mL to obtain calcium phosphate bone cement slurry;

[0046] Dissolving xanthan gum and white dextrin in 0.25 mol / L disodium hydrogen phosphate solution to form a solidified solution, wherein the mass fraction of xanthan gum in the solidified solution is 0.5%, and the mass fraction of white dextrin is 0.5%;

[0047] (3) The calcium phosphate bone cement slurry is printed by 3D printing technology to obtain the calcium p...

Embodiment 2

[0054] A preparation method of calcium phosphate / bioactive glass bone repair bracket, comprising the following steps:

[0055] (1) The bone cement solid phase powder and bioactive glass are mixed at a mass ratio of 1:0.04 to obtain a mixed powder; the solid phase powder includes polyethylene glycol, α-tricalcium phosphate, calcium carbonate and calcium hydrogen phosphate, so The massfraction of polyethylene glycol in the solid phase powder is 0.6%;

[0056] (2) Mix the mixed solid phase powder and the solidified liquid according to the solid-to-liquid ratio of 1g:0.5mL to obtain calcium phosphate bone cement slurry;

[0057] Dissolving xanthan gum and white dextrin in 0.25 mol / L disodium hydrogen phosphate solution to form a solidified solution, wherein the mass fraction of xanthan gum in the solidified solution is 0.5%, and the mass fraction of white dextrin is 0.5%;

[0058] (3) The calcium phosphate bone cement slurry is printed by 3D printing technology to obtain the calc...

Embodiment 3

[0065] A preparation method of calcium phosphate / bioactive glass bone repair bracket, comprising the following steps:

[0066] (1) Mix the bone cement solid phase powder and bioactive glass at a mass ratio of 1:0.06 to obtain a mixed powder; the solid phase powder includes polyethylene glycol, α-tricalcium phosphate, strontium-doped octacalcium phosphate and strontium-doped Amorphous calcium phosphate; in the solid phase powder, the molar ratio of strontium to calcium is: strontium:calcium=0.1:1; the molar ratio of the sum of calcium and strontium to phosphorus is: calcium+strontium:phosphorus=1.1: 1; the mass fraction of polyethylene glycol in the solid phase powder is 0.6%;

[0067] (2) Mix the mixed solid phase powder and the solidified liquid according to the solid-to-liquid ratio of 1g:0.45mL to obtain calcium phosphate bone cement slurry;

[0068] Dissolving xanthan gum and white dextrin in 0.25 mol / L disodium hydrogen phosphate solution to form a solidified solution, w...

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Abstract

The invention discloses a calcium phosphate / bioactive glass bone repair bracket and a preparation method thereof. According to the calcium phosphate / bioactive glass bone repair bracket disclosed by the invention, calcium phosphate bone cement and bioactive glass are used as raw materials, a 3D printing technique is used, and the calcium phosphate / bioactive glass bone repair bracket having communicating macropores is obtained. The bioactive glass can promote a hydration reaction of bone cement, and shorten the coagulation time; besides, the solidified bracket releases Ca ions, P ions and Si ions through quick dissolution of bioglass, so that the degradation properties of the bracket are improved, and more stable chemical bonds and higher biological activity are provided. The bracket is modified through gelatin, so that the mechanical strength of the bracket can be effectively improved. The prepared bone repair bracket disclosed by the invention has communicating macropores, the mechanical strength of the bone repair bracket meets demands of spongy bones, and the bone repair bracket has excellent biocompatibility, can effectively promote regeneration of bone tissues, and has a favorable application prospect in the field of bone tissue repair.

Description

technical field [0001] The invention relates to the technical field of bone repair materials, in particular to a calcium phosphate / bioactive glass bone repair bracket and a preparation method thereof. Background technique [0002] Bone is an important tissue of the human body. Although it has bone regeneration and self-repair capabilities, for bone defects caused by tumors, trauma, and abnormal bone growth, in the case that bone self-repair alone cannot heal, it is necessary to use implant materials to assist the damage. Tissue repair and healing. From the perspective of bone tissue self-healing, an ideal bone repair scaffold needs to have good biocompatibility, biodegradability, three-dimensional porous structure, and a complex shape that matches the defect site. The porous bone repair scaffold has a high specific surface area and space, which is conducive to the loading of active factors, cell adhesion and growth, deposition of extracellular matrix, entry of nutrients and...

Claims

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Application Information

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IPC IPC(8): C04B38/00C04B28/34B33Y10/00B33Y70/00
CPCB33Y10/00B33Y70/00C04B28/344C04B2111/00181C04B2111/40C04B14/22C04B38/0054C04B38/0003
Inventor 车七石
Owner GUANGZHOU RAINHOME PHARM&TECH CO LTD
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