A kind of erythromycin thiocyanate enteric-coated pellets and preparation method thereof

A technology of erythromycin thiocyanate and enteric-coated pellets, applied in the field of veterinary medicine, can solve problems such as poor oral palatability, and achieve the effects of improving stability and improving bioavailability

Active Publication Date: 2021-10-29
RINGPU TIANJIN BIOLOGICAL PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The present invention aims to overcome the defects in the prior art, provide a kind of erythromycin thiocyanate enteric-coated pellets and a preparation method thereof, solve the problem of poor oral palatability of erythromycin thiocyanate powder, and improve animal feed intake; And improve the stability of erythromycin thiocyanate in acid, improve the bioavailability of the drug in animals, and better meet the needs of modern farming

Method used

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  • A kind of erythromycin thiocyanate enteric-coated pellets and preparation method thereof
  • A kind of erythromycin thiocyanate enteric-coated pellets and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Table 1 10% content specification prescription

[0036] Name of raw material Amount added (g) Erythromycin Thiocyanate 10 (converted content) Low-substituted hydroxypropyl cellulose 2 sucrose 10 Mannitol added to 85 2% Hydroxypropyl Cellulose 80 Cellulose acetate phthalate 10 Titanium dioxide 2.0 polyethylene glycol 400 3.0 acetone 80

[0037] Preparation process

[0038] (1) Take by weighing erythromycin thiocyanate, low-substituted hydroxypropyl cellulose, sucrose and mannitol and mix uniformly by prescription quantity;

[0039] (2) Take 1.6g of hypromellose by weighing according to the prescription quantity and throw it into 80g of purified water, cut and dissolve for 15min, and obtain the adhesive;

[0040] (3) Put the powder in step (1) into the tank mixer machine, mix with the binder of step (2) to prepare soft material, and discharge;

[0041] (4) Add the soft material prepared in step (3) to...

Embodiment 2

[0046] Table 2 30% content specification prescription

[0047] Name of raw material Amount added (g) Erythromycin Thiocyanate 30 (converted content) Crospovidone 2 sucrose 10 Dextrin added to 70 1% hypromellose 65 Hydroxypropyl Methyl Cellulose Phthalate 27 silica 5.0 Triacetin 2.0 40% ethanol in water 80

[0048] Preparation process

[0049] (1) take erythromycin thiocyanate, polyvinylpolypyrrolidone, sucrose and dextrin and mix uniformly by recipe quantity;

[0050] (2) Take 0.65g of hypromellose by weighing according to the prescription quantity and throw it into 65g of purified water, cut and dissolve for 15min, and obtain the adhesive;

[0051] (3) Put the powder in step (1) into the tank mixer machine, mix with the binder of step (2) to prepare soft material, and discharge;

[0052] (4) Add the soft material prepared in step (3) to the spherical extruder for 45 rotations to extrude, and spheronize in...

Embodiment 3

[0057]Table 3 20% content specification prescription

[0058] Name of raw material Amount added (g) Erythromycin Thiocyanate 20 (converted content) Carboxymethyl Starch Sodium 2 microcrystalline cellulose 30 starch added to 80 1%pvpk30 76 Acrylic 14 silica 3.0 triethyl citrate 3.0 acetone 70

[0059] Preparation process

[0060] (1) take by weighing erythromycin thiocyanate, sodium starch glycolate, microcrystalline cellulose and starch by recipe quantity and mix;

[0061] (2) Weigh 0.76g pvpk30 according to the prescription amount and drop it into 76g purified water, cut and dissolve for 15min to obtain the adhesive;

[0062] (3) Put the powder in step (1) into the tank mixer machine, mix with the binder of step (2) to prepare soft material, and discharge;

[0063] (4) Add the soft material prepared in step (3) to the spherical extruder for 45 rotations to extrude, and spheronize in the spheronizer at 600...

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Abstract

An erythromycin thiocyanate enteric-coated pellet relates to the field of veterinary medicine. The erythromycin thiocyanate pellet is composed of a pellet core and a coating solution, and the pellet core is composed of the following components in percentage by weight: sulfur 10%-40% erythromycin cyanate, 23%-84% excipient, 1%-5% disintegrant, 0%-2% binder; 5%-30% weight gain of the coating solution. In addition, it also relates to the preparation method of the erythromycin thiocyanate enteric-coated pellets, which can cover the bitter taste of the erythromycin thiocyanate, ensure that the preparation will not be degraded and destroyed in gastric acid, and significantly improve the bioavailability of the drug in animals Spend.

Description

technical field [0001] The invention relates to the field of veterinary medicine, in particular to veterinary drugs, in particular to erythromycin thiocyanate enteric-coated pellets and a preparation method thereof. Background technique [0002] Erythromycin thiocyanate is currently the thiocyanate of the commonly used macrolide antibiotic erythromycin. This product is a veterinary drug used to treat Gram-positive bacteria and mycoplasma infections. Animal Growth Promoter", it is listed as my country's four major export veterinary antibiotic products together with Tylosin, Tetracycline Hydrochloride and Oxytetracycline. [0003] The antibacterial mechanism of erythromycin thiocyanate is based on a macrolide as the mother nucleus, which is connected with 1 to 3 molecular sugars by glycosidic bonds through the hydroxyl group, which can inhibit bacterial protein synthesis. The effect of this product on gram-positive bacteria is similar to that of penicillin, but its antibacteri...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/50A61K47/38A61K47/26A61K47/32A61K31/7048A61P31/04
CPCA61K9/5015A61K9/5026A61K9/5042A61K31/7048A61P31/04
Inventor 聂丽娜李晓慧夏雪林刘爱玲李守军吴燕子
Owner RINGPU TIANJIN BIOLOGICAL PHARMA
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