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Multifunctional polyphosphazene bone repair material with anti-oxidation and osteogenesis promoting capability and preparation method of multifunctional polyphosphazene bone repair material

A technology of osteogenic ability and polyphosphazene, which is applied in pharmaceutical formulations, medical science, prostheses, etc., can solve the problems of ROS enrichment, adverse effects of tissue regeneration, single form and function, etc., and achieves easy regulation of performance and molecular structure. Designable effects

Inactive Publication Date: 2019-09-27
BEIJING UNIV OF CHEM TECH
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  • Abstract
  • Description
  • Claims
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Problems solved by technology

[0005] In view of the relatively single form and function of bone regeneration filling materials used in clinical practice, they cannot well meet the needs of various bone defects for repair materials, and the realization of ideal bone regeneration and repair is still facing challenges. The development of multifunctional repair Materials are one of the effective solutions, and the purpose of the present invention is to address the specific problem that ROS is prone to enrichment at the defect site, which adversely affects tissue regeneration, and to synthesize a class that has both antioxidant properties and the ability to promote osteogenic differentiation. biodegradable polyphosphazene material, and prepared into injectable microspheres for bone defect regeneration filling repair

Method used

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  • Multifunctional polyphosphazene bone repair material with anti-oxidation and osteogenesis promoting capability and preparation method of multifunctional polyphosphazene bone repair material
  • Multifunctional polyphosphazene bone repair material with anti-oxidation and osteogenesis promoting capability and preparation method of multifunctional polyphosphazene bone repair material
  • Multifunctional polyphosphazene bone repair material with anti-oxidation and osteogenesis promoting capability and preparation method of multifunctional polyphosphazene bone repair material

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preparation example Construction

[0025] (1) Preparation and purification of linear polydichlorophosphazene: put the purified hexachlorocyclotriphosphazene into the polymerization tube, vacuumize the oxygen and water removal and seal the tube under vacuum, then place the polymerization tube at 250°C Polymerize at low temperature for 24-60 hours, then break the polymerization tube to take out the polymer, add dry petroleum ether to wash three times to remove unreacted monomers, and obtain linear polydichlorophosphazene.

[0026] (2) Preparation of amino acid ester solution: Dissolve amino acid ester hydrochloride and acid-binding agent in dry tetrahydrofuran (200mL) according to the amount of substances 1:2, reflux for 6-48 hours, and filter to remove the generated acid-binding agent hydrochloric acid salt to obtain a tetrahydrofuran solution of amino acid esters.

[0027] (3) Nucleophilic substitution of linear polydichlorophosphazene: dissolve polydichlorophosphazene in dry tetrahydrofuran (100mL) 2 - The mola...

Embodiment 1

[0031] Put the purified hexachlorocyclotriphosphazene (30g) into the polymerization tube, vacuumize (10mbar), fill with dry nitrogen, repeat three times to remove oxygen and water from the system, seal the tube under vacuum, and then place it at 250°C Polymerization was carried out for 48 hours. After the polymerization reaction, break the polymerization tube to take out the polymer, add dry petroleum ether to wash three times to remove unreacted monomers, and obtain linear polydichlorophosphazene.

Embodiment 2

[0033] Polydichlorophosphazene (containing 8.62mmol-PNCl 2 -Structural unit) was dissolved in 100mL of dry tetrahydrofuran, 1.73mmol of aniline tetramer and 1.73mmol of triethylamine were added, and reacted at 50°C for 24 hours under anhydrous and oxygen-free conditions, and then added with 18.64mmol of glycine ethyl ester salt acid salt and 37.28mmol triethylamine reflux reaction for 6 hours of tetrahydrofuran solution (200mL), continue to react at 35 ℃ for 24 hours, to obtain poly (aniline tetramer / ethyl glycine) phosphazene, wherein, the substitution of aniline tetramer The ratio was ~10 mol%, and the substitution ratio of glycine ethyl ester was ~90 mol%.

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Abstract

The invention discloses a multifunctional polyphosphazene bone repair material with anti-oxidation and osteogenesis promoting capability and a preparation method of the multifunctional polyphosphazene bone repair material, and relates to the field of bone regeneration repair materials. The material is a microsphere which is prepared from an alternating phosphorus-nitrogen inorganic structure as a main chain and an organic-inorganic hybrid polymer with antioxidative active organic side groups and biodegradable organic side groups, and the particle size is in a range of 100-300 mu m. The microsphere can be injected into a defect part in the form of a microcellular vector to promote bone regeneration and repair. The invention also provides the preparation method of the material.

Description

technical field [0001] The invention relates to the field of bone regeneration and repair materials, in particular to a biodegradable polyphosphazene microsphere material with anti-oxidation and bone-promoting properties and a preparation method thereof. Background technique [0002] In the tissue defect or surgical site, because the cells are in a state of stress, a large amount of reactive oxygen species (ROS) is usually produced locally. Although an appropriate amount of ROS has been proved to be beneficial to cell proliferation, when the excessive ROS is concentrated in the defect position, it is easy to cause Apoptosis of surrounding normal cells and stimulation of inflammatory response. In bone tissue defect sites, ROS can also activate the overexpression of osteoclasts, which is very unfavorable for new bone formation and regeneration and repair of defect sites. Based on the principle of bone tissue engineering, the strategy of bone regeneration and repair is general...

Claims

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Application Information

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IPC IPC(8): A61L27/18A61L27/58
CPCA61L27/18A61L27/58A61L2400/06A61L2430/02C08L85/02
Inventor 蔡晴黄一谦李业晨杨小平
Owner BEIJING UNIV OF CHEM TECH
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