Flexible surface enhanced raman scattering substrate based on single-layer ordered nanoparticle array

Abstract

The invention provides a flexible surface enhanced raman scattering substrate based on a single-layer ordered nanoparticle array. The flexible surface enhanced raman scattering substrate comprises a flexible base material layer, a light-cured resin layer, nano particles and a metal coating which are sequentially arranged from bottom to top, the surface of the flexible base material layer is coatedwith the light-cured resin layer formed by a light-cured resin material, and the limiting structure array is processed on the surface of the light-cured resin material of the light-cured resin layerby using a roller press forming process; and each limiting structure is provided with a space which contains one nano particle and of which the nano particle can be exposed out, the single-layer ordered nanoparticle array is formed, and then the nano particles can be limited. According to the flexible surface enhanced raman scattering substrate based on the single-layer ordered nanoparticle array,the limit structure array is processed through the roller press forming process, the process is simple, the cost is low, the efficiency is high, batch production can be realized, and the large-area consistency is good; and the spacing and the array mode of the limiting structures are regulated and controlled so that the gaps and the array modes of the nano particles can be accurately controlled,and the optimal plasma resonance effect is obtained, that is, the optimal raman enhancement effect is achieved.

Description

technical field [0001] The disclosure relates to the technical field of biological detection, in particular to a flexible surface-enhanced Raman scattering substrate based on a single-layer ordered nanoparticle array and a preparation method thereof. Background technique [0002] As a powerful experimental method, surface-enhanced Raman scattering (SERS) is widely used in many fields such as chemistry, catalysis, biology, medicine, environment, food safety, etc. It can provide non-destructive, ultra-sensitive characterization, detection limit down to the single-molecule level. In the fields of in-situ detection of pesticide residues on the surface of fruits and vegetables, in-situ detection of pollutants in aqueous solution, real-time detection of microorganisms, and rapid on-site analysis of chemical reactions, SERS substrates are required to have excellent flexibility and transparency. [0003] Noble metal nanoparticles such as gold and silver are commonly used in surface...

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Problems solved by technology

[0003] Noble metal nanoparticles such as gold and silver are commonly used in surface-enhanced Raman scattering (SERS), but SERS substrates based on nanoparticles are prone to problems such as difficult control of order and uniformity, and poor signal reproducibility.

[0004] Chinese patent CN 109060762 A discloses a composite flexible surface-enhanced Raman substrate based on silver nanoparticles and a preparation method thereof, using a chemical reduction method to prepare silver colloids containing a large amount of silver nanoparticles; Polydimethylsiloxane (PDMS) is mixed to form a suspension, which is dripped on the surface of the hard substrate, heated and cured to form a PDMS film containing a large amount of silver nanoparticles, and peeled off; finally, the dipping method is used to prepare A layer of silver nanoparticles is transferred on a good film to prepare a composite flexible surface-enhanced Raman substrate based on silver nanoparticles. This patent does not regulate the order and uniformity of the nanoparticles, and cannot guarantee the accuracy of multiple measurements. Signal reproducibility

[0005] Chinese patent CN 109650392 A discloses a method for preparing sensitive and stable TiC surface-enhanced Raman scattering nanoparticles, including the following steps: after stirring anhydrous titanium chloride and ethanol evenly, adding lithium powder, stirring again The solution is placed in a stainless steel autoclave and reacted at high temperature to obtain highly stable TiC nanomaterials. The order and uniformity of nanoparticles are not regulated in this patent

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