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A ferrimagnetic nanomaterial and its application in magnetic particle imaging

A technology of magnetic particle imaging and nanomaterials, which can be applied to medical preparations with inactive ingredients, preparations for in vivo experiments, microcapsules, etc. Uniform and controllable imaging effect, size and shape

Active Publication Date: 2021-04-20
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, unlike the traditional co-precipitation method or hydrothermal method that directly obtains IONPs in the aqueous phase system, the IONPs prepared by this method can only be well dispersed in non-polar solvents. Agglomeration of nanoparticles is prone to occur, so surface modification is required for good water dispersion and colloidal stability

Method used

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  • A ferrimagnetic nanomaterial and its application in magnetic particle imaging
  • A ferrimagnetic nanomaterial and its application in magnetic particle imaging
  • A ferrimagnetic nanomaterial and its application in magnetic particle imaging

Examples

Experimental program
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Effect test

Embodiment 1

[0031] Embodiment 1: the synthesis of cube-shaped iron ferric oxide nanoparticles

[0032] Mix 0.71 g of iron acetylacetonate with 0.4 g of biphenyl-4-carboxylic acid, 1.27 g of oleic acid, and 10.4 g of dibenzyl ether, stir at room temperature for 1 h under vacuum, and heat the mixture to 290 °C at a rate of 20 °C / min. ℃, when the temperature of the system reaches 290 ℃, keep the temperature for 30 minutes, cool it rapidly, wash the product with a 4:1 mixed solution of toluene and hexane, and then resuspend it in chloroform for storage. The particle size is 20-25nm. The X-ray diffraction result of the cube-shaped iron ferric oxide nanoparticles prepared in this embodiment is as follows figure 1 As shown, it is proved that the obtained nanoparticles are ferric oxide crystal form; the magnetization curve results are as follows figure 2 As shown, it shows that the obtained nanoparticles are ferrimagnetic, with high saturation magnetization and magnetic susceptibility, low coe...

Embodiment 2

[0033] Embodiment 2: the synthesis of cube-shaped iron ferric oxide nanoparticles

[0034] Mix 0.71g of iron acetylacetonate with 1.13g of oleic acid and 52g of dibenzyl ether, stir at room temperature for 1h under vacuum, and raise the temperature of the mixture to about 290°C at a rate of 20°C / min. When the system temperature reaches 290°C, keep The temperature was 15 minutes, cooled rapidly, the product was washed with a 4:1 mixed solution of toluene and hexane, and then resuspended in chloroform for storage. The obtained cubic iron ferric oxide nanoparticles had a size of 25-30nm.

Embodiment 3

[0035] Embodiment 3: the synthesis of ferrimagnetic nanomaterial

[0036] Disperse 2-5 mg of cubic iron ferric oxide nanoparticles synthesized in Example 1 and 10-50 mg of phospholipid polyethylene glycol in a mass ratio of 5:1 in 10-50 mL of chloroform. The organic solvent was evaporated under reduced pressure to form a thin film. Continue to add 2-5 mL of double distilled water for hydration to obtain monodisperse cubic magnetic nanoparticles in the aqueous phase system. The morphology of the cube-shaped magnetic nanoparticles was characterized by transmission electron microscopy, and the results are as follows: image 3 As shown, it can be seen from the figure that the synthesized nanoparticles are cubes with uniform size, and the core size is about 20-25nm.

[0037] Using dynamic light scattering to analyze the particle size distribution of cubic magnetic nanoparticles, the results are as follows Figure 4 As shown, the results prove that the cube-shaped magnetic nanopa...

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Abstract

The invention discloses a ferrimagnetic nanometer material, which comprises cubic iron ferric oxide nanometer particles and phospholipid polyethylene glycol coated on the outer layer of the cubic iron ferric oxide nanoparticle. The invention also discloses the application of ferrimagnetic nanometer material in magnetic particle imaging. The ferrimagnetic nanometer material provided by the invention can be stably dispersed in an aqueous phase system, has excellent magnetic particle imaging effect, and is a sensitive and efficient MPI contrast agent.

Description

technical field [0001] The invention relates to the application of magnetic nanometer materials, in particular to a ferrimagnetic nanometer material and its application in magnetic particle imaging. Background technique [0002] Magnetic Particle Imaging (MPI) is an emerging imaging technology that directly detects magnetic nanomaterials, mainly iron oxide nanoparticles (IONPs), through a time-varying magnetic field, with high sensitivity, high resolution, high signal-to-noise ratio, and high specificity. , The signal does not attenuate with depth, no radiation, etc. At the same time, the preparation process of the contrast agent IONPs required for imaging is relatively simple, easy to large-scale industrial production, compared with some other metal materials, it is almost non-toxic to cells, and has better safety. , so MPI has broad application prospects in cell tracking, disease diagnosis and treatment, and vascular imaging. [0003] However, the current commercial MPI c...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K49/00A61K9/50A61K47/24
CPCA61K9/5031A61K49/00
Inventor 凌代舜李方园王绮玥
Owner ZHEJIANG UNIV
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