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Preparation method for ganoderma lucidum spore powder sustained-release microcapsules

A technology of Ganoderma lucidum spore powder and slow-release microcapsules, which is applied in the direction of microcapsules, capsule delivery, and medical preparations of non-active ingredients, etc. It can solve the problems of Ganoderma lucidum spore oil being easily oxidized, the embedding rate needs to be improved, and the absorption effect is affected. , to achieve a good slow-release effect, improve the practical value and utilization rate, and improve the stability

Active Publication Date: 2020-02-21
INST OF AGRO FOOD SCI & TECH SHANDONG ACAD OF AGRI SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] Ganoderma lucidum spore powder contains a variety of effective biologically active substances, but it is easy to lose its activity at room temperature. Ganoderma lucidum spore oil is more likely to oxidize and reduce its efficacy
Chinese patent application CN201810102485.3 discloses a Ganoderma lucidum spore powder microcapsule and its preparation method. In this method, gelatin and cyclodextrin are used as wall materials, and a single Ganoderma lucidum spore powder is used as the core material. The prepared microcapsules have good homogeneity However, the microcapsules prepared by this method are still layered after standing, and the embedding rate still needs to be improved, and the microcapsules prepared by this method are directly released, which affects the absorption effect
And at present, when Ganoderma lucidum spore powder is directly prepared into microcapsules, the embedding rate is low and the stability is poor

Method used

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  • Preparation method for ganoderma lucidum spore powder sustained-release microcapsules
  • Preparation method for ganoderma lucidum spore powder sustained-release microcapsules
  • Preparation method for ganoderma lucidum spore powder sustained-release microcapsules

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Effect test

Embodiment 1

[0029] (1) Select immature and disease-free green bananas, peel them, add 3 times the volume of ice water, beat at 2200rpm for 8 minutes, add pullulanase, cellulase and brewer's yeast according to the mass ratio of 1:1:2 Composed of compound enzymes, the inoculation amount of compound enzymes accounts for 2.5% of the mass of green bananas, enzymatic hydrolysis at 30-35 ° C for 1.5 hours, and then carbon dioxide is introduced to form a foam slurry with a density of 0.6 g / cm 3 , continue the heat preservation enzymatic hydrolysis for 1.5h, filter the slag with 3 layers of non-woven gauze to obtain green banana pulp, and vacuum concentrate the green banana pulp to a solid content of 30% at 70-80°C to obtain concentrated green banana pulp;

[0030] (2) Add 0.2 part of sodium alginate and 0.1 part of stachyose to 100 parts of green banana concentrated pulp, stir well to make a mixture;

[0031] (3) After soaking the white fungus, take it out, make a pulp, concentrate until the wat...

Embodiment 2

[0036] (1) Select immature and disease-free green bananas, peel them, add 3 times the volume of ice water, beat at 2000rpm for 8 minutes, add pullulanase, cellulase and brewer's yeast according to the mass ratio of 1:1:2 Composed of compound enzymes, the inoculum amount of compound enzymes accounts for 2% of the mass of green bananas, enzymatic hydrolysis at 30-35°C for 1.5 hours, and then carbon dioxide is introduced to form a foam slurry with a density of 0.7g / cm 3 , continue to heat-preserve the enzymatic hydrolysis for 1.5 hours, filter the slag with 3 layers of non-woven gauze to obtain green banana pulp, and vacuum concentrate the green banana pulp to a solid content of 36% at 70-80°C to obtain concentrated green banana pulp;

[0037] (2) Add 0.2 part of sodium alginate and 0.1 part of stachyose to 100 parts of green banana concentrated pulp, stir well to make a mixture;

[0038] (3) After soaking the white fungus, take it out, make a pulp, concentrate until the water c...

Embodiment 3

[0043] (1) Select immature and disease-free green bananas, peel them, add 3 times the volume of ice water, beat at 2500rpm for 8 minutes, add pullulanase, cellulase and brewer's yeast according to the mass ratio of 1:1:2 Composed of compound enzymes, the inoculum amount of compound enzymes accounts for 3% of the mass of green bananas, enzymolysis at 30-35°C for 1.5 hours, and then carbon dioxide is introduced to form a foam slurry with a density of 0.8g / cm 3 , continue to heat-preserve the enzymatic hydrolysis for 1.5h, filter the slag with 3 layers of non-woven gauze to obtain green banana pulp, and vacuum concentrate the green banana pulp to a solid content of 40% at 70-80°C to obtain concentrated green banana pulp;

[0044] (2) Add 0.2 part of sodium alginate and 0.1 part of stachyose to 100 parts of green banana concentrated pulp, stir well to make a mixture;

[0045] (3) After soaking the white fungus, take it out, make a pulp, concentrate until the water content is 25%, a...

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Abstract

The invention belongs to the technical field of health-care product preparation, and particularly relates to a preparation method for ganoderma lucidum spore powder sustained-release microcapsules. The microcapsules are prepared by the following steps: firstly processing green bananas to obtain green banana concentrated slurry, preparing a wall material and a core material solution, performing mixing, performing grinding through a colloid mill, performing homogenization, and performing spray drying to obtain the product. According to the method, ganoderma lucidum spore powder is used to prepare the microcapsules, after microencapsulation, the influence of environmental factors on the stability of the ganoderma lucidum spore powder can be avoided, the stability of the ganoderma lucidum spore powder can be improved, and the functionality of the ganoderma lucidum spore powder can be maintained; according to the preparation method provided by the invention, the extraction rate of resistantstarch in the green bananas is high, the content of pectin in the resistant starch is high, the green banana concentrated slurry is used to prepare the wall material under the synergistic action of sodium alginate and stachyose, the embedding rate is high, and the microcapsules prepared from the wall material have good stability, no delamination, and a good sustained-release effect; and the method has a simple process, uses the green bananas as the main raw material, improves the practical value and utilization rate of the green bananas, and is suitable for industrial production.

Description

technical field [0001] The invention belongs to the technical field of preparation of health care products, and in particular relates to a preparation method of ganoderma lucidum spore powder slow-release microcapsules. Background technique [0002] Ganoderma lucidum is a well-known medicinal fungus, also known as Seicao, a large fungus with high medicinal value. In recent years, it has been widely used in the treatment and prevention of various cardiovascular diseases, liver and kidney diseases, neurological diseases, etc. common diseases. Although Ganoderma lucidum has a very long history of medicinal use in my country, the haze-shaped, egg-shaped germ cells ejected from the cap of Ganoderma lucidum during the mature stage, that is, Ganoderma lucidum spores, were not recognized and utilized until the 20th century. Ganoderma lucidum spores contain Ganoderma lucidum seeds Almost all active substances in the entity include polysaccharides, triterpenoids, proteins, sterols, nu...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/074A61K9/62A61K47/46A61K47/36A61K47/26A61P9/00A61P1/16A61P13/12A61P25/00A61P35/00A61P39/06A61P37/04
CPCA61K36/074A61K9/5063A61K9/5036A61K9/5015A61K9/5089A61P9/00A61P1/16A61P13/12A61P25/00A61P35/00A61P39/06A61P37/04
Inventor 巩东营王恒振李志国
Owner INST OF AGRO FOOD SCI & TECH SHANDONG ACAD OF AGRI SCI
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