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Cetirizine pseudoephedrine sustained-release capsule and preparation method thereof

A pseudoephedrine and sustained-release capsule technology is applied in the directions of capsule delivery, microcapsules, pharmaceutical formulations, etc., and can solve the drug release interference of cetirizine and pseudoephedrine, cetirizine-pseudoephedrine sustained-release capsule or tablet preparation process is cumbersome, etc. problems, to achieve the effect of reducing the number of doses, small tablet weight, and good reproducibility of the release curve

Inactive Publication Date: 2020-04-10
白喜平
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The object of the present invention is to provide a kind of cetirizine pseudoephedrine sustained-release capsule, which solves the problem of mutual interference of cetirizine and pseudoephedrine drug release in the prior art
[0006] Another object of the present invention is to provide a preparation method of cetirizine pseudoephedrine sustained-release capsules, which solves the cumbersome problem in the preparation process of cetirizine pseudoephedrine sustained-release capsules or tablets in the prior art

Method used

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Examples

Experimental program
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Effect test

preparation example Construction

[0029] A preparation method for cetirizine pseudoephedrine sustained-release capsules, comprising the steps of:

[0030] The first step is to weigh 5-8mg of cetirizine hydrochloride, 90-110mg of lactose, 30-70mg of microcrystalline cellulose, 20-30mg of excipients, 4-9mg of coating material, 100-150mg of pseudoephedrine hydrochloride, and 60- 80mg, blocker 20-40mg, magnesium stearate 2-6mg;

[0031] In the second step, the cetirizine hydrochloride and lactose microcrystalline cellulose weighed in the first step are uniformly mixed, crushed with a pulverizer, and sieved to obtain a mixture of 80 to 90 meshes;

[0032] In the third step, add 5% povidone ethanol solution to the mixture obtained in the second step, stir at a speed of 200-600r / min for 10-15 minutes, prepare granules with a size of 10-15 mesh, and obtain after drying Whole grain;

[0033] The fourth step is to add the excipients, coating materials and magnesium stearate weighed in the first step to the whole grain...

Embodiment 1

[0038] The first step, weigh 5 mg of cetirizine hydrochloride, 90 mg of lactose, 30 mg of microcrystalline cellulose, 20 mg of hypromellose, 4 mg of polyvinyl alcohol, 100 mg of pseudoephedrine hydrochloride, 60 mg of sodium alginate, 20 mg of ethyl cellulose, hard Magnesium fatty acid 2mg;

[0039] In the second step, the cetirizine hydrochloride and lactose microcrystalline cellulose weighed in the first step are mixed uniformly, crushed with a pulverizer, and sieved to obtain a mixture of 80 meshes;

[0040] In the third step, add 5% povidone ethanol solution to the mixture obtained in the second step, stir at a speed of 200 r / min for 10 minutes, prepare granules with a size of 10 mesh, and obtain granules after drying;

[0041] In the fourth step, add the hypromellose, polyvinyl alcohol, and magnesium stearate weighed in the first step to the whole grains obtained in the third step, and mix evenly to prepare pellets with a size of 14 meshes, namely Obtain the cetirizine h...

Embodiment 2

[0046] The first step, weigh 8 mg of cetirizine hydrochloride, 110 mg of lactose, 70 mg of microcrystalline cellulose, 30 mg of acrylic resin, 9 mg of polyethylene glycol, 150 mg of pseudoephedrine hydrochloride, 80 mg of hydroxypropyl cellulose, and 40 mg of glyceryl monostearate , magnesium stearate 6mg;

[0047] In the second step, the cetirizine hydrochloride and lactose microcrystalline cellulose weighed in the first step are mixed uniformly, crushed with a pulverizer, and sieved to obtain a 90-mesh mixture;

[0048] In the third step, add 5% povidone ethanol solution to the mixture obtained in the second step, stir at a speed of 600r / min for 15 minutes, prepare granules with a size of 15 meshes, and obtain granules after drying;

[0049] In the fourth step, add the acrylic resin, polyethylene glycol, and magnesium stearate weighed in the first step to the granule obtained in the third step, and mix evenly to prepare pellets with a size of 20 meshes to obtain hydrochloric...

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Abstract

The invention provides a cetirizine pseudoephedrine sustained-release capsule and a preparation method thereof. The capsule is filled with cetirizine hydrochloride quick-release pellets and pseudoephedrine hydrochloride sustained-release pellets. The cetirizine hydrochloride quick-release pellet in each capsule is prepared from the components of 5 to 8mg of cetirizine hydrochloride, 90 to 110mg oflactose, 30 to 70mg of microcrystalline cellulose, 20 to 30mg of auxiliary materials, 4 to 9mg of coating materials and 1 to 3mg of magnesium stearate. The pseudoephedrine hydrochloride sustained-release pellet is prepared from the components of 100 to 150mg of pseudoephedrine hydrochloride, 60 to 80mg of a framework material, 20 to 40mg of a retardant and 1 to 3mg of magnesium stearate. The cetirizine hydrochloride quick-release pellets and the pseudoephedrine hydrochloride slow-release pellets are mixed. The process is simple. Dissolution and release of the two medicines do not interfere with each other. The release curve reproducibility is good. The tablet weight is small, and production and split charging are facilitated.

Description

technical field [0001] The invention belongs to the technical field of medicine preparation, relates to a cetirizine-pseudoephedrine sustained-release capsule, and also relates to a preparation method of the cetirizine-pseudoephedrine sustained-release capsule. Background technique [0002] Rhinitis refers to inflammation of the nasal mucosa and submucosal tissues. Manifested as congestion or edema, patients often have symptoms such as nasal congestion, runny nose, nasal itching, throat discomfort, coughing, etc. The thin liquid-like substance secreted by the nasal cavity is called nasal mucus or nasal secretion, and its function is to help remove dust and bacteria. to keep the lungs healthy. Under normal circumstances, the nasal mucus mixed with bacteria and dust is sucked into the throat and finally into the stomach. Because of the small amount of secretion, it generally does not attract people's attention. When there is inflammation in the nose, a large amount of nasal m...

Claims

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Application Information

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IPC IPC(8): A61K9/52A61K47/38A61K31/495A61K31/137A61P11/02A61P37/08
CPCA61K9/1652A61K9/5042A61K9/5084A61K31/137A61K31/495A61P11/02A61P37/08A61K2300/00
Inventor 白喜平
Owner 白喜平
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