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A kind of composite bone repair material and preparation method thereof

A composite material and bone repair technology, which is applied in the fields of pharmaceutical formulations, prostheses, drug delivery, etc., can solve the problem that it is difficult to continuously provide other nutrients for bone growth tissue, bone repair materials are difficult to effectively use oral alveolar sockets, and biologically active factors Osteogenic site enrichment and other issues, to achieve a significant surface isolation effect, inhibit the ability of bacterial infection, and promote the effect of osteoinductive growth

Active Publication Date: 2021-10-22
AFFILIATED HOSPITAL OF WEIFANG MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the porous calcium phosphate scaffold-loaded microsphere composite has the effect of filling bone reconstruction and osteoinductive osteogenesis, the loaded drug is not suitable for the oral environment, and it is easy to escape under the action of cavity fluid
[0010] In summary, the bone repair materials in the prior art are difficult to be effectively used in the alveolar socket of the oral cavity. The main problems are:
[0013] However, at present, bone repair materials are mainly used in the environment of closed bone defects, which are difficult to be used in the open and complex environment of the oral cavity, and there are many disadvantages: for example, the scaffold material is easily infiltrated by saliva, and the slowly released bioactive factors are easily diluted and difficult to repair. It is enriched in the osteogenic site, and it is also difficult to continuously provide other nutrients to the required bone growth tissue, which is not conducive to bone proliferation and promotes bone tissue growth

Method used

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  • A kind of composite bone repair material and preparation method thereof
  • A kind of composite bone repair material and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

preparation example 1

[0101] Preparation of porous bioactive bottom matrix

[0102] S1: 4g of hydroxyapatite powder and 2g of bioactive glass powder (55% SiO 2 -35%CaO-10%P 2 o 5 ) was added to 65ml of 1,4-dioxane solvent, and then magnetically stirred for 12 minutes to mix evenly, so that the particles were uniformly dispersed in the organic solvent to obtain a suspension of biologically active particles.

[0103] S2: 20 mL of polyε-caprolactone-dioxane solution with a mass concentration of 0.1 g / mL and 50 mL of PLGA with a mass concentration of 0.2 g / mL (the monomer ratio of polylactic acid and glycolic acid is 50:50) mixed dichloromethane solution to obtain PLGA / polyε-caprolactone mixed polymer organic solution;

[0104] S3: Add the above-mentioned bioactive particle suspension into the above-mentioned high molecular polymer organic solution, stir rapidly for preliminary mixing, and then ultrasonically disperse at room temperature for 1 min after rapid stirring and mixing, and then take an ap...

preparation example 2

[0107] Prepare the upper matrix premix slurry

[0108] S1: Dissolve 10g PLGA (molecular weight 60,000-80,000, polylactic acid and glycolic acid monomer ratio is 70:30) in 50mL dichloromethane, inject 5mL deionized water into it, and shear at 8500r / min After 1min, add it to 200mL 5% polyvinyl alcohol solution, and continue high-speed shearing for 1min; 12g; Rotary evaporation at 35-45°C to remove the organic solvent, then stand at room temperature for precipitation for 1 hour, centrifuge to separate the precipitate, wash thoroughly with deionized water, and freeze-dry to obtain PLGA microspheres;

[0109] Mix 5 g of the above-obtained PLGA microspheres and 55 g of calcium phosphate-based composite bone cement with a particle size of 10-15 μm at room temperature, and dry to obtain PLGA microspheres / calcium phosphate-based composite bone cement powder;

[0110] Among them, the calcium phosphate-based composite bone cement is composed of 80% β-tricalcium phosphate, 15% anhydrous ...

preparation example 3

[0114] Preparation of composite adhesives for bonding upper and lower end matrix scaffolds

[0115] S1: In a heated crucible, 2 g of bioactive glass particles (based on molar ratio, 55% SiO 2 -35%CaO-10%P 2 o 5 , particle size ≤ 40 μm) was added to 5 g of molten PLGA (particle size 50 μm, LA / GA = 1), stirred and mixed at 200 ° C, then cooled to room temperature, pulverized and granulated so that the particle size did not exceed 100 μm , to obtain embedding particles containing bioactive glass particles.

[0116] S2: Mix 3g of the above embedding granules, 4g of PLGA powder (LA / GA=1), 13g of n-butyl α-cyanoacrylate and 150mg of povidone-iodine (containing 12% available iodine), and stir for 3 minutes until uniform to obtain a composite adhesive.

[0117] According to GB / T 7124-2008, the bonding strength between the adhesive and the aluminum plate after curing for 15 minutes is 5.85±0.36MPa, which has excellent bonding force.

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Abstract

The invention relates to a filling scaffold material with a three-layer structure suitable for bone repair and a preparation method thereof; wherein the bottom end of the bone repair scaffold has a multi-level porous structure with high porosity, which can slowly release bioactive factors and improve bone damage sites It has good biological activity and osteoinductive ability, which is beneficial to enhance osteogenesis and bone remodeling; the upper end is a low-porosity bone cement matrix barrier layer, and the middle layer is an adhesive layer. The composite scaffold of the present invention can effectively promote the repair and regeneration of bone tissue by utilizing the barrier effect of the upper layer and the osteogenic effect of the lower layer. points, and has a synergistic effect with the skeleton.

Description

technical field [0001] The invention belongs to the field of orthopedic materials, in particular to a bioactive composite matrix orthopedic repair filling material with a gradient pore structure and a preparation method thereof. Background technique [0002] In orthopedic clinical practice, guided tissue regeneration using bionic bone is a commonly used bone repair method. In dental practice, tooth extraction and dental implant after tooth extraction are common operations. However, due to individual differences, alveolar bone defect or underestimation is a common situation, especially when the thickness and bone density of the alveolar socket bone are not ideal, which will seriously affect the implant effect. [0003] Therefore, it has a good application prospect to repair the bone in the alveolar region before implantation, promote the thickness and density of the alveolar bone, and overcome the defect of insufficient alveolar bone. [0004] At present, bone repair materi...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/10A61L27/12A61L27/16A61L27/18A61L27/20A61L27/24A61L27/50A61L27/52A61L27/56A61L27/58
CPCA61L27/10A61L27/12A61L27/16A61L27/18A61L27/20A61L27/24A61L27/50A61L27/52A61L27/56A61L27/58A61L2400/06A61L2430/02C08L67/04C08L5/08C08L39/06
Inventor 杨杨牟亚男
Owner AFFILIATED HOSPITAL OF WEIFANG MEDICAL UNIV
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