Preparation method of boron-containing nano targeted drug

Abstract

The invention relates to a preparation method of a boron-containing nano targeted drug, which comprises the following steps: (1) dissolving an amphiphilic polymer in an organic solvent to obtain an organic solution; adding a boron-containing drug into an aqueous solution containing an emulsifier, uniformly mixing, dropwise adding the obtained system into the above organic solution, and stirring toobtain a w / o emulsion; (2) dropwise adding the w / o emulsion into another aqueous solution containing the emulsifier, stirring, and then removing the organic solvent to obtain a w / o / w double emulsion;and freeze-drying the w / o / w double emulsion to obtain the boron-containing nano targeted drug. The preparation process of the boron-containing nano targeted drug is simple and convenient, the synthesis condition is mild, and expanded production is facilitated. Compared with free BPA, the prepared nano targeted drug has the advantages that the hematoma ratio is remarkably increased and reaches upto 4.1: 1, the tumor treatment effect can be remarkably improved, and the nano targeted drug has very good application prospects when being independently used as an anti-tumor drug and being combinedwith paclitaxel and other anti-tumor drugs for use.

Description

technical field [0001] The invention belongs to the field of drug delivery systems, and in particular relates to a preparation method of a boron-containing nano-targeted drug. Background technique [0002] Due to the difficulty of surgery and drug treatment, sensitive lesion site, easy to cause complications, low cure rate but high morbidity and mortality, the treatment of malignant tumors has become a major problem in the world. Recently, researchers found that compared with traditional treatment methods, boron neutron capture therapy (BNCT) showed excellent effect on malignant tumors. [0003] Neutron capture therapy is to make corresponding pro-tumor drugs from nuclides with large neutron reaction cross-sections, and inject the drugs into the body of tumor patients. The ion capture reaction uses the secondary radiation and recoil particles produced by the nuclear reaction to kill cancer cells. Its main advantages are as follows: ① Neutron capture therapy drugs (usually ...

AI Technical Summary

Problems solved by technology

②Traditional radiotherapy requires oxygen to enhance the effect of biological radiation. However, due to the rapid and aggressive growth of malignant tumors, the blood supply of tumor tissue is often insufficient, resulting in local hypoxia, which reduces the effect of radiotherapy

However, due to the structural characteristics of boron-containing drugs, it is actually difficult to prepare a composite system containing boron-containing drugs. At present, there are few reports on the composite system containing boron-containing drugs with high swollen blood ratio.

Images