Unlock instant, AI-driven research and patent intelligence for your innovation.

A kind of production process of glycerol fructose sodium chloride injection

A technology of sodium chloride injection and production process, which is applied in the direction of blood diseases, extracellular fluid diseases, active ingredients of hydroxyl compounds, etc. Problems such as slow heat conduction can reduce the probability of bursting bottles (bags), improve production safety, and speed up preheating

Active Publication Date: 2021-03-23
HUAXIASHENGSHENG PHARMA BEIJING CO LTD
View PDF2 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] There are also some technical solutions for the production of glycerin fructose injection in the prior art, such as a Chinese patent with application number 2018116099458, which discloses a production process of glycerin fructose sodium chloride injection, which ensures that the fructose in the finished product content, and keep 5-HMF within the standard range, and more effectively prevent pyrogen substances from being mixed into the finished product, but when performing water bath or steam sterilization for large infusions, the packaging container (glass bottle, plastic bottle or multi-layer co-extruded bag ) is large and not easy to transfer heat, which makes it take a long time to sterilize the large infusion, which in turn affects the production efficiency of the injection. , plastic bottle or multi-layer co-extrusion bag) the drug at the high temperature state for a long time and scrapped, thereby affecting the quality of the drug, accordingly, the present invention proposes a production process of glycerol fructose sodium chloride injection

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • A kind of production process of glycerol fructose sodium chloride injection
  • A kind of production process of glycerol fructose sodium chloride injection
  • A kind of production process of glycerol fructose sodium chloride injection

Examples

Experimental program
Comparison scheme
Effect test

specific Embodiment approach

[0036] As a specific embodiment of the present invention, the prescription feeding of glycerin fructose injection comprises by weight:

[0037] Glycerin 9-11 parts

[0038] 4-6 servings of fructose

[0039] Sodium chloride 1-3 parts

[0040] 1-3 parts of pH regulator

[0041] 78-82 parts of water for injection.

[0042] As a specific embodiment of the present invention, the preparation temperature in S2 is 10-30°C, the pH regulator in S3 is hydrochloric acid or sodium hydroxide, and micropores below 0.22um are used for filtration in S4, and fructose is filtered at high temperature. Or generate this impurity of 5-hydroxymethylfurfural under weak acid condition, the present invention adopts preparation temperature control, pH adjuster selection and microporous filtration, controls fructose to the intermediate product of 5-hydroxymethylfurfural conversion process, thereby effectively reduces 5-hydroxymethylfurfural HMF content.

[0043] As a specific embodiment of the presen...

Embodiment 1

[0049] A kind of glycerin fructose sodium chloride injection production technology, comprises the following steps:

[0050] S1: Add 70% water for injection into the preparation container, control the temperature at 60°C, add the prescribed amount of sodium chloride and glycerin, stir for 12 minutes to dissolve the sodium chloride and glycerin, and obtain the medicinal solution 1;

[0051] S2: Lower the preparation temperature of S1 Chinese medicinal solution 1 to 15°C, add the prescribed amount of fructose, stir for 8 minutes to dissolve the fructose, and set the volume to the prepared amount to obtain medicinal solution 2. Prepare medicinal liquid 1 and medicinal liquid 2 Inert gas protection is used in the process;

[0052] S3: After circulating the second medicinal solution in S2 for 15 minutes, use a pH regulator to adjust the second medicinal solution so that the pH value of the second medicinal solution is 4.0, and obtain the finished injection. Sampling and characterizi...

Embodiment 2

[0055] A kind of glycerin fructose sodium chloride injection production technology, comprises the following steps:

[0056]S1: Add 70% water for injection into the preparation container, control the temperature at 60°C, add the prescribed amount of sodium chloride and glycerin, stir for 12 minutes to dissolve the sodium chloride and glycerin, and obtain the medicinal solution 1;

[0057] S2: Lower the preparation temperature of S1 Chinese medicinal solution 1 to 40°C, add the prescribed amount of fructose, stir for 8 minutes to dissolve the fructose, and set the volume to the prepared amount to obtain medicinal solution 2. Prepare medicinal liquid 1 and medicinal liquid 2 Inert gas protection is used in the process;

[0058] S3: After circulating the second medicinal solution in S2 for 15 minutes, use a pH regulator to adjust the second medicinal solution so that the pH value of the second medicinal solution is 4.0, and obtain the finished injection. Sampling and characterizin...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention belongs to the technical field of injection production. The invention relates to a production process of a sodium chloride injection, in particular to a glycerin-fructose-sodium chlorideinjection production process. A temperature uniformizing device used in the process comprises a mounting plate, first push rod motors are arranged at the two ends of the mounting plate correspondingly. Guiding plates are fixed to the output shaft ends of the two first push rod motors correspondingly. The first push rod motor is used for driving the guide plate to move, wherein two or more guide grooves are formed in the bottom end of the guide plate in the length direction of the guide plate, sliding blocks are movably installed in the guide grooves, limiting springs are fixed to the bottom ends of the sliding blocks, and vertical plates are fixed to the ends, away from the corresponding sliding blocks, of the limiting springs. By shaking the large infusion solution, the injection in thelarge infusion solution shakes, so that preheating of the large infusion solution is accelerated, the time required for water bath of the large infusion solution is shortened, and the production efficiency of the large infusion solution is effectively improved; meanwhile, due to clamping of the clamping blocks, the probability of bottle (bag) burst of large infusion is reduced, and the productionsafety of the large infusion is improved.

Description

technical field [0001] The invention belongs to the technical field of injection production, in particular to a production process of glycerin fructose sodium chloride injection. Background technique [0002] Glycerin fructose is a compound preparation, which is a highly permeable dehydration drug. Glycerol can participate in brain metabolism and improve brain metabolism; fructose can be metabolized and utilized without insulin; sodium chloride can regulate electrolyte balance. The mechanism of action of this product is: after intravenous injection, it can increase the plasma osmotic pressure, causing the water in the tissue to enter the blood vessel, thereby reducing tissue edema, reducing intracranial pressure, intraocular pressure, and the volume and pressure of cerebrospinal fluid; Move to the blood, dilute the blood, reduce the edema around capillaries, improve microcirculation, increase cerebral perfusion pressure, increase cerebral blood flow, increase blood supply a...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/7004A61K31/047A61K9/08A61K47/02A61K47/04A61P7/10A61P9/10A61P25/00
CPCA61K9/0019A61K9/08A61K31/047A61K31/7004A61K47/02A61P7/10A61P9/10A61P25/00A61K2300/00
Inventor 吕新安
Owner HUAXIASHENGSHENG PHARMA BEIJING CO LTD