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Patchouli oil soft capsules for treating acute upper respiratory infection and treatment method thereof

A patchouli oil, upper respiratory tract technology, applied in capsule delivery, essential oils/spices, respiratory system diseases, etc., can solve the problems of no antiviral drugs, loss of volatile components, failure to play a role, etc., to avoid Liver first-pass effect, improving stability, avoiding drug resistance and dependence

Inactive Publication Date: 2020-09-04
YUNNAN LVXIN BIOLOGICAL PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] There are the following deficiencies in the treatment of upper respiratory tract infection: first, a large number of antibiotics and drug resistance problems; second, antiviral specific drugs have not been found for viral infections; Fourth, Chinese patent medicines fail to play a role due to the loss of many curative volatile components in the process of pharmacy or decoction

Method used

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  • Patchouli oil soft capsules for treating acute upper respiratory infection and treatment method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] 1. Extraction of Patchouli Oil

[0031]A patchouli oil soft capsule for treating acute upper respiratory tract infection and its therapy. The patchouli oil is extracted by steam distillation, and the steps are as follows: weigh 500g of patchouli dry aerial part, crush it and place it in a round bottom Add 5000ml of distilled water to the flask, soak at room temperature for 12 hours, then sonicate for 30 minutes, and heat and distill for 5 hours. When there are no more oil droplets on the condenser tube, it means that the distillation is complete. Put the obtained product into a separatory funnel, add an appropriate amount of petroleum ether, shake well and extract. After standing still, take the upper layer, absorb excess water with anhydrous sodium sulfate, transfer to a distillation flask, and evaporate in a vacuum at 45°C. After the petroleum ether evaporates completely, get patchouli oil, weigh it, store it at 4°C for later use, and release the oil The rate is 1.5%...

Embodiment 2

[0039] Embodiment 2 In vitro antibacterial test of patchouli oil

[0040] 1. Materials

[0041] Tested strains: Streptococcus pneumoniae, Staphylococcus, Escherichia coli, Staphylococcus aureus.

[0042] 2. Method

[0043] The inhibitory effect of the patchouli oil extracted in Example 1 on the growth of the test bacteria was measured by the cup and saucer method and the double-layer plate method. Invert the bottom plate first, then absorb 10 mL of the prepared bacterial solution, and mix it into 90 mL of culture medium cooled to about 45°C, so that the final concentration of the bacterial solution is 10 6 ~10 7 cfu / mL to prepare the upper plate with bacteria. After solidification, a sterile Oxford cup was placed symmetrically on the plate, and 100 μL of patchouli oil was added to the Oxford cup, and three parallel experiments were carried out, with sterile water as the blank control. Incubate at 37°C for 24-36 hours, measure the size of the inhibition zone by the cross m...

Embodiment 3

[0048] Example 3 Anti-inflammatory effect of patchouli oil

[0049] 1. Experimental grouping

[0050] Blank control group: 0.5% Tween-80 saline, orally administered at a dose of 20ml / kg.

[0051] Administration group: take the patchouli oil extracted in Example 1, and administer it by intragastric administration at a low dose of 0.1 ml / kg and a high dose of 1 ml / kg.

[0052] Positive control group: dexamethasone, administered orally at a dose of 5 mg / kg.

[0053] 2. Method

[0054] Take 40 mice weighing 25.0±1.0 g, half male and half male, 10 mice in each group. On the basis of normal feeding, the blank control group was given intragastric administration of 0.5% Tween-80 normal saline (20ml / kg), and the treatment group was intragastrically administered once a day (low dose 0.1ml / kg, high dose 1ml / kg) , the positive control group was administered dexamethasone (5 mg / kg) for 5 consecutive days. One hour after the last administration, each mouse in each group was evenly smea...

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Abstract

The invention discloses patchouli oil soft capsules for treating acute upper respiratory infection and a treatment method thereof. Patchouli is an important Lingnan genuine medicinal material; and patchouli oil is a volatile component of the patchouli and is widely applied as medicinal extract. The patchouli oil has wide pharmacologic effects of resisting to bacteria, resisting to viruses, resisting to inflammation, relieving cough and reducing sputum, alleviating pain, resisting to plasmodia, regulating a gastrointestinal motion function, carrying out immunoregulation and the like. Accordingto the invention, the patchouli oil is used as a pharmaceutical effect ingredient; the patchouli oil is prepared into a soft capsule dosage form; an electronic heater is used as a drug delivery tool;the soft capsules are broken by utilizing a mechanical structure of the heater so as to slowly release volatile oil contained in the soft capsules; in an electrical heating mode, the volatile oil is vaporized; the vaporized volatile oil is inhaled into the respiratory tract through a mouth and a nose; and pharmaceutical effect molecules can directly reach lesion positions of a nasal cavity, a pharyngeal part, a throat and the like and rapidly take effects. The treatment method is used as a respiratory system disease targeted drug delivery approach, has obvious quick-acting and positioning effects, adopts local application, is rapid in pharmaceutical effect and small in dosage, and has an obvious curative effect of treating acute upper respiratory infection.

Description

technical field [0001] The invention belongs to the field of natural medicines, in particular to a patchouli oil soft capsule for treating acute upper respiratory tract infection and its therapy. Background technique [0002] Acute upper respiratory tract infection (AURTI) refers to the general term for acute inflammation from the nostril to the lower edge of the cricoid cartilage, including the nasal cavity, pharynx or larynx, and is the most common infectious disease of the respiratory tract. The main clinical manifestations of infection are rhinitis, pharyngitis and tonsillitis. The incidence is regardless of gender, age, occupation and region, and those with low immune function are susceptible. [0003] Modern medicine believes that the common cause of acute upper respiratory tract infection is virus, and a few are caused by bacteria. Due to different pathogens, it can be divided into two categories: acute viral and bacterial upper respiratory tract infections. Acute ...

Claims

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Application Information

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IPC IPC(8): A61K36/532A61K9/48A61K9/00A61K47/10A61K47/44A61P11/00A61P31/04C11B9/02
CPCA61K9/007A61K9/4825A61K9/4858A61K36/532A61P11/00A61P31/04C11B9/022C11B9/025C11B9/027Y02A50/30
Inventor 王钲霖刘胜贵薛红芬付彬彬李智高孔令羽蒋永昌马海悦
Owner YUNNAN LVXIN BIOLOGICAL PHARMA CO LTD
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