Efficient thin layer chromatographic separation method based on metal organic framework material composite photonic crystal thin layer

A technology of metal-organic frameworks and photonic crystals, applied in material separation, analytical materials, instruments, etc., can solve problems such as inability to separate, limited improvement in separation efficiency, and no reports on photonic crystal thin-layer chromatography separation technology, so as to ensure high efficiency Separation, strong adsorption and desorption effect and selectivity, and the effect of making up for poor separation effect

Active Publication Date: 2020-09-04
EAST CHINA NORMAL UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The applicant of the present invention has publicly published in 2017 about "based on mesoporous SiO 2 Thin-layer chromatographic separation of photonic crystals" academic paper, but the separation efficiency of the thin-layer chromatographic stationary phase in the above work is limited compared to commercial silica ge

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  • Efficient thin layer chromatographic separation method based on metal organic framework material composite photonic crystal thin layer
  • Efficient thin layer chromatographic separation method based on metal organic framework material composite photonic crystal thin layer
  • Efficient thin layer chromatographic separation method based on metal organic framework material composite photonic crystal thin layer

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Experimental program
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Effect test

Embodiment 1

[0080] Embodiment 1. Preparation of SiO 2 photonic crystal thin layer

[0081] use Monodisperse SiO with an average particle size of 200 nm prepared by method 2 colloidal particles. Take 80 μL of SiO 2 The colloidal particles were dispersed in 1 mL of ethanol, and 120 μL of ethylene glycol was added for ultrasonic mixing to form a homogeneous transparent solution. The mixed solution was placed in an oven at 90° C. for 2 hours to evaporate and remove the ethanol in the solution, and finally 200 μL of a colloidal supersaturated solution with a volume fraction of 40% colloidal particles was obtained. Take 30 μL of the above precursor solution and drop it on the hydrophilic glass substrate treated with piranha solution, and spread the precursor solution evenly into a liquid film with a thickness of about 100 μm by coating method. Stand at room temperature for 15 minutes. After a large number of colloidal crystals are precipitated to form liquid colloidal crystals, transfer t...

Embodiment 2

[0082] Embodiment 2. Preparation of metal-organic framework material composite photonic crystal (MOF-PC) thin layer

[0083] First, the SiO after calcined in Example 1 of the present invention 2 The photonic crystal thin layer was soaked in piranha solution for 12 hours to recover the surface hydroxyl groups. Subsequent hydroxylated SiO 2 The photonic crystal thin layer was soaked in 0.06% aminopropyltriethoxysilane (APTES) ethanol solution with a volume fraction of 0.06%, reacted at room temperature for 12 hours, was taken out and washed with ethanol and dried to obtain a photonic crystal thin layer modified with amino groups on the surface. Finally, soak the thin layer of amino-modified photonic crystals in a succinic anhydride dimethylformamide solution with a concentration of 0.005 g / mL, react at room temperature for 12 hours, wash with ethanol and dry after removal to obtain photonic crystals rich in carboxyl groups on the surface. crystal thin layer.

[0084] Thin lay...

Embodiment 3

[0085] Example 3. Using spatially resolved reflectance spectroscopy to determine the position of the sample point on the photonic crystal thin-layer plate

[0086] The position of the chemical substance sample point on the MOF-PC thin-layer plate described in Example 2 of the present invention can be directly observed with the naked eye, or can be accurately determined by using spatially resolved reflectance spectroscopy (SRRS). In actual operation, the optical fiber probe of the spectrometer is usually fixed above the thin-layer chromatography plate, and the thin-layer plate is pulled along the opposite direction of the sample development at a constant rate of 2 cm / min, so that the spectrometer can continuously record the MOF-PC thin-layer plate along the sample. The direction of the spectral change. A series of spectral data is plotted as a three-dimensional reflection spectrum with the ratio shift (Rf) value on the x-axis, the reflection wavelength on the y-axis, and the re...

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Abstract

The invention discloses a metal organic framework material composite photonic crystal (MOF-PC) thin layer and an efficient thin layer chromatography separation technology based on an MOF-PC thin layerplate. As a chromatographic stationary phase, the MOF-PC thin layer has a high specific surface area and a specific microporous structure so that the MOF-PC thin layer shows stronger adsorption and desorption effects and selectivity in separation, the inherent defect of poor separation effect caused by a small number of thin-layer chromatographic tower plates is effectively overcome, and efficient separation of mixed substances is ensured. The MOF-PC thin layer also has the specific structural color and reflection signal of the photonic crystal so that the specific position of the sample canbe directly determined by utilizing the structural color difference between the sample point and the thin layer plate and the change of the reflection signal, and the chromatographic parameters such as the specific shift value, the selection factor and the separation degree are obtained. Compared with the methods in the prior art, the technology has the advantages that the separation effect is remarkably improved, and substances with similar structures, which cannot be separated by traditional thin-layer chromatography, can be separated. Besides, the technology directly recognizes sample points by means of structural colors without extra operations such as ultraviolet irradiation and laminate dyeing, and provides a green, convenient and safe new way for sample detection.

Description

technical field [0001] The invention belongs to the application field of photonic crystal materials and the technical field of thin-layer chromatography separation, and specifically relates to a high-efficiency thin-layer chromatography technology using metal-organic framework material composite photonic crystal thin-layer plate as a stationary phase. Background technique [0002] Thin-layer chromatography uses a thin layer of particles coated on a glass plate as the stationary phase, uses a specific solvent as the mobile phase, and uses the differential adsorption and desorption between chemical substances and the stationary phase to separate and identify mixed samples. A chromatographic separation technique. Since it was proposed in the 1950s, this technology has been widely used in food safety testing, drug identification and metabolite analysis, organic synthesis, chemical product identification, drug analysis, and pesticide residue detection due to its convenient operat...

Claims

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Application Information

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IPC IPC(8): G01N30/92G01N30/93G01N30/90
CPCG01N30/90G01N30/92G01N30/93
Inventor 葛建平傅茜茜冉玉梅张欣
Owner EAST CHINA NORMAL UNIV
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