A kind of preparation method and using method of inorganic hybrid self-healing hydrogel
A self-healing and hydrogel technology, which can be used in pharmaceutical formulations, prostheses, drug delivery, etc., can solve the problems of uneven dispersion of manganese dioxide nanomaterials and poor tissue affinity of hydrogels, and achieve efficient removal of active free base, good biocompatibility, and the effect of alleviating hypoxic conditions
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[0026] Preparation method of inorganic hybrid self-healing hydrogel
[0027] Step 1: Dissolve tetramethylammonium hydroxide in a 3% aqueous hydrogen peroxide solution, quickly pour it into the manganese salt solution, and keep stirring.
[0028] Step 2: The obtained black precipitate is centrifuged, washed and dried with deionized water, and then ultrasonically peeled off to obtain a two-dimensional manganese dioxide nanosheet with a single-layer structure.
[0029] Step 3: mixing polylysine and manganese dioxide nanosheets to obtain polylysine-modified manganese dioxide composite nanosheets.
[0030] Step 4: Modification of phenolic groups to both ends of polyether F127, and self-assembly in water to obtain F127 aldehyde micelles.
[0031] Step 5: The polylysine-modified manganese dioxide composite nanosheets were blended with F127 modified with phenolic groups at both ends at 4 °C, and gelatinized at 37 °C to obtain a hybrid self-healing hydrogel.
[0032] Described divale...
Embodiment 1
[0043] Example 1: Preparation of polylysine-modified manganese dioxide two-dimensional nanosheets
[0044]Dissolve 0.378g of manganese dichloride in 10ml of deionized aqueous solution, weigh 2.2g of tetramethylammonium hydroxide and dissolve it in 3% hydrogen peroxide solution, add it to the above manganese dichloride solution quickly, 600 Continuous stirring at r / min, black manganese dioxide precipitate was obtained after the reaction for 12 hours, after removing unreacted manganese dichloride and tetramethylammonium hydroxide with deionized water, ultrasonic peeling for 30min to obtain a single-layer structure of manganese dioxide dimensional nanosheets, and the final product obtained is freeze-dried. Disperse the above manganese dioxide nanosheets into deionized water, prepare a 10 mg / ml solution, mix it with a 20 mg / ml polylysine solution, fully stir for 12 hours, and wash with deionized water three times after centrifugation. The product was freeze-dried.
Embodiment example 2
[0045] Example 2: Preparation of polyether F127 aldehyde modified with phenolic groups at both ends
[0046] 12.6 g of polyether F127 with an average molecular weight of 12.6 kDa was dried at 80° C. for 12 hours, 120 ml of dichloromethane was added, placed in an ice bath, and 0.875 ml of triethylamine was added rapidly. Under the protection of nitrogen atmosphere, 0.32 ml of methanesulfonyl chloride was dissolved in 20 ml of dichloromethane, and slowly added to the above mixture, and the reaction was carried out at room temperature for 24 hours. After the reaction was completed, 150 mL of deionized water was added, and extracted three times with 100 mL of dichloromethane. The organic phase was washed twice with 100 ml of 1M hydrochloric acid solution and saturated brine respectively, and then anhydrous sodium sulfate was added to remove excess water. Diethyl ether was added to the concentrated mixture to precipitate the product, which was purified three times and then dried i...
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