Woven reinforced degradable polyurethane elastomer artificial blood vessel and preparation method thereof

A polyurethane elastomer and artificial blood vessel technology, which is applied in the field of artificial blood vessels, can solve the problems of lack of availability, stay, and small-diameter artificial blood vessels have not yet appeared, and achieves the effects of low price, good mechanical properties, and a simple and efficient preparation method.

Active Publication Date: 2021-02-26
SHANGHAI SIXTH PEOPLES HOSPITAL
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The research on the synthesis of degradable polyurethane with PCL diol as a monomer and its application in small blood vessel tissue engineering has never stopped in the past two decades, but most of the research is only at the level of material modification and in vitro cell experiments , even some in vivo transplantation studies will not get good results because of acute coagulation or proliferation problems (Fang J., Zhang J.L., Du J., et al. Orthogonally functionalizable polyurethane with subsequent modification with heparin and endothelium-inducing peptide aiming for vascular reconstruction [J]. ACS Applied Materials & Interfaces, 2016, 8, 14442-14452.)
So far, there have been no reports on the preparation of small-caliber artificial blood vessels by combining electrospinning technology, weaving technology and thermal phase separation technology.

Method used

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  • Woven reinforced degradable polyurethane elastomer artificial blood vessel and preparation method thereof
  • Woven reinforced degradable polyurethane elastomer artificial blood vessel and preparation method thereof
  • Woven reinforced degradable polyurethane elastomer artificial blood vessel and preparation method thereof

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preparation example Construction

[0040] The invention provides a method for preparing a braided reinforced degradable polyurethane elastomer artificial blood vessel, comprising the following steps:

[0041] Step 1, mixing and dissolving one or several masterbatches among PLGA, PDO, and PGA to obtain a composite spinning solution;

[0042] Step 2, spinning the above-mentioned composite spinning solution using a double-needle counter-jet electrospinning system to obtain nanofiber yarns, and weaving the nanofiber yarns into tubular braids;

[0043] Step 3, Spin the stainless steel of the mold through electrospinning technology, first spin PEO (polyethylene oxide) nanofibers, and then spin C-PEEUU-NH 2 nanofibers; the loaded PEO, C-PEEUU-NH 2 The stainless steel with nanofibers was demolded in ultrapure water; the C-PEEUU-NH 2 The nanofiber tubular scaffold was stirred and washed in ultrapure water until the surface impurities were removed, and then vacuum freeze-dried;

[0044] Step 4, using activated H 2 N-...

Embodiment 1

[0077] This embodiment provides a braided reinforced degradable polyurethane elastomer artificial blood vessel, refer to figure 1 and figure 2 , its preparation method comprises the following steps:

[0078] (1) Weaving PLGA / silk fibroin nanofiber yarns (the mass ratio of PLGA and silk fibroin is 1:1) (12 filaments with a single filament diameter of 10 μm) into a tubular braid;

[0079] (2) Spin PEO nanofibers with a thickness of about 5 μm on the 316L stainless steel with a diameter of 2 mm by electrospinning technology; continue to spin C-PEEUU-NH with a thickness of 100 μm on the fiber 2 nanofibers; link the above with PEO, C-PEEUU-NH 2 The 316L stainless steel with nanofibers was demoulded in ultrapure water; the C-PEEUU-NH 2 Continue to stir and wash the nanofiber tubular scaffold in ultra-pure water for 30 minutes to remove impurities on the surface of the fiber, then vacuum freeze-dry and set aside;

[0080] (3) The prepared C-PEEUU-NH 2 The nanofiber tubular scaf...

Embodiment 2

[0085] This embodiment provides a braided reinforced degradable polyurethane elastomer artificial blood vessel, refer to figure 1 and image 3 , its preparation method comprises the following steps:

[0086] (1) PLGA / PDO / PGA / silk fibroin nanofiber yarn (PLGA / PDO / PGA total mass and silk fibroin mass ratio is 4:1, wherein PLGA, PDO and PGA in PLGA / PDO / PGA total mass The mass ratio is 1:1:1) (a total of 12 single filaments with a diameter of 10 μm) are woven into tubular braids;

[0087] (2) Spin PEO nanofibers with a thickness of about 5 μm on the 316L stainless steel with a diameter of 2 mm by electrospinning technology; continue to spin C-PEEUU-NH with a thickness of 100 μm on the fiber 2 nanofibers; link the above with PEO, C-PEEUU-NH 2 The 316L stainless steel with nanofibers was demoulded in ultrapure water; the C-PEEUU-NH 2 Continue to stir and wash the nanofiber tubular scaffold in ultra-pure water for 30 minutes to remove impurities on the surface of the fiber, then va...

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Abstract

The invention provides a woven reinforced degradable polyurethane elastomer artificial blood vessel and a preparation method thereof. The inner layer of the artificial blood vessel adopts activated H2N-PEG-COOH, heparin and (Mpa)-GGGGGREDV polypeptide to treat a C-PEEUU-NH2 electrospun nanofiber tubular stent to obtain a C-PEEUU-PEG-Hep/REDV tubular stent, the middle layer adopts a woven reinforced layer of nanofiber yarns woven by dissolving and mixing one or more master batches of PLGA, PDO and PGA according to a mass ratio, and the outer layer is a macroporous layer prepared by thermally induced phase separation. The woven reinforced degradable polyurethane elastomer artificial blood vessel provided by the invention can be used for tissue regeneration and construction of cardiovascularand cerebrovascular diseases, the preparation method is simple and efficient, the price is low, and the prepared artificial blood vessel has resilience, compliance, bursting strength and biocompatibility matched with autologous vascular tissues. The artificial blood vessel has no hypersensitivity to a human body in a transplantation operation, has affinity with blood and peripheral tissues in thehuman body, and has a good application prospect in repair operations of cardiology surgery, nephrology surgery and brain surgery.

Description

technical field [0001] The invention relates to the field of artificial blood vessels, in particular to a braided reinforced degradable polyurethane elastomer artificial blood vessel and a preparation method thereof. Background technique [0002] According to the World Health Report of the World Health Organization (WHO), the number of deaths from cardiovascular and cerebrovascular diseases in the world accounts for 30.3% of the total death population. In my country, the morbidity and mortality of cardiovascular and cerebrovascular diseases rank first among various diseases, and the morbidity and mortality of cardiovascular and cerebrovascular diseases in China are still rising. According to statistics from the Ministry of Health, there are 290 million people with cardiovascular and cerebrovascular diseases in my country, and it is estimated that by 2020, the number will exceed 320 million. At present, the most effective method for treating cardiovascular and cerebrovascula...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/18A61L27/20A61L27/22A61L27/50A61L27/58D06M15/03D06M15/53D06M13/432D01D5/00D04C1/06D06M101/38
CPCA61L27/227A61L27/18A61L27/20A61L27/507A61L27/50A61L27/58D06M15/03D06M15/53D06M13/432D01D5/0069D01D5/003D04C1/06D06M2101/38C08L89/00C08L75/06C08L71/02C08L5/10
Inventor 朱同贺赵金忠莫秀梅蒋佳吴晶磊
Owner SHANGHAI SIXTH PEOPLES HOSPITAL
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