Construction and application of endoplasmic reticulum targeted nano drug delivery system

A nano-drug loading and endoplasmic reticulum technology, which is applied in nano-drugs, endocrine system diseases, nanotechnology, etc., can solve the problems of inability to deliver active molecules in a targeted manner, and cannot realize carrier functions, etc., and achieve good industrial production and application prospects, design Novel schemes to improve the effect of accumulation
CN112472822AActive Publication Date: 2021-03-12ZHEJIANG UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
ZHEJIANG UNIV
Publication Date
2021-03-12

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Abstract

The invention provides construction and application of an endoplasmic reticulum targeted nano drug delivery system. By modifying sulfamide or sulfonylurea compounds with endoplasmic reticulum tendencyinto endoplasmic reticulum targeting nano-compounds constructed in a nano-carrier, the constructed novel endoplasmic reticulum targeting liposome can load water-soluble and fat-soluble drugs and quickly transfer the drugs to the endoplasmic reticulum part, so that accumulation of the drugs at the action part of the liposome is improved, and the bioavailability of the drugs is improved. The medicine treatment effect is enhanced, and the toxic and side effect is weakened; the delivery of nucleic acid drugs needing lysosome escape can be remarkably improved, and a new strategy is provided for exerting the curative effect of the drugs. The nano-carrier disclosed by the invention is not only limited to lipidosome, but also can be solid lipid nanoparticles, nano-emulsion, polymer micelles and the like. The endoplasmic reticulum targeted modification nano-carrier provided by the invention is novel in scheme and simple in preparation method, and has good industrial production and applicationprospects.
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Description

technical field

[0001] The invention belongs to the field of pharmacy, and relates to the construction of a kind of endoplasmic reticulum targeting nano-drug loading system and its application in the fields of anti-tumor, anti-metabolic disorder, anti-virus and anti-inflammation. Background technique

[0002] Drug action targets involve receptors, enzymes, ion channels, transporters, immune system and genes, etc., and drugs need to reach the action targets to exert their efficacy. Modern drug delivery systems require that drugs can be transported to target tissues, target cells, and even specific organelles. At present, the research on tissue and cell-targeted drug delivery systems is relatively mature, and tertiary targeting, that is, organelle targeting, is a hot and difficult point in the current research on drug delivery systems. Tertiary targeting includes cytoplasmic targeting and organelle targeting, and organelle targeting includes mitochondrial targeting, endoplasm...

Claims

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