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Broccoli extract and charcoal compound, preparation method and application thereof

An extract and biochar technology, applied in the field of daily chemicals, can solve the problems of destroying the oral microecological balance, dysbiosis in the oral cavity, and easy to produce side effects. Effect

Inactive Publication Date: 2021-04-30
CHINA PHARM UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Oral care is a very important aspect of daily life. However, the oral products used in daily life can only play a role in cleaning the oral cavity. Most of the oral care products on the market currently add disinfectants or drugs to treat oral diseases. If things go on like this, It is easy to produce side effects, cause bacteria to develop drug resistance, and the flora in the oral cavity is out of balance, destroying the micro-ecological balance of the oral cavity

Method used

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  • Broccoli extract and charcoal compound, preparation method and application thereof
  • Broccoli extract and charcoal compound, preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] The toothpaste chewable tablet with anti-helicobacter pylori containing broccoli extract / biochar complex consists of the following components by weight percentage: broccoli extract / biochar complex 3wt%, calcium carbonate 55wt%, dodecane 2wt% sodium hydroxysulfate, 1wt% peppermint oil, 0.5wt% mannitol, 1wt% sodium carboxymethylcellulose, 0.5wt% magnesium stearate.

[0028] The preparation method comprises the following steps:

[0029] (1) The broccoli extract / biochar composite, the weight percentage is the calcium carbonate of 20wt%, sodium lauryl sulfate, peppermint oil, mannitol grind and mix, add carboxymethyl cellulose sodium and mix and make soft material ;

[0030] (2) pass through a 14-mesh sieve to make wet granules, and dry at 60-80°C;

[0031] (3) the dried particles pass through a 12-mesh sieve;

[0032] (4) After adding the remaining calcium carbonate and magnesium stearate, compress into tablets.

[0033] Wherein, the broccoli extract / biochar complex is ...

Embodiment 2

[0042] The toothpaste chewable tablet with anti-helicobacter pylori containing broccoli extract / biochar complex consists of the following components by weight percentage: broccoli extract / biochar complex 6wt%, calcium carbonate 45wt%, dodecane 1.5wt% sodium hydroxysulfate, 0.5wt% peppermint oil, 0.01wt% mannitol, 1.2wt% sodium carboxymethylcellulose, 1wt% magnesium stearate.

[0043] The preparation method comprises the following steps:

[0044] (1) The broccoli extract / biochar composite, the calcium carbonate of 15wt% by weight percentage, sodium lauryl sulfate, peppermint oil, mannitol are ground and mixed, add sodium carboxymethyl cellulose and mix to make soft material ;

[0045] (2) pass through a 14-mesh sieve to make wet granules, and dry at 60-80°C;

[0046] (3) the dried particles pass through a 12-mesh sieve;

[0047] (4) After adding the remaining calcium carbonate and magnesium stearate, compress into tablets.

[0048] The preparation method of the broccoli ext...

Embodiment 3

[0050] The toothpaste chewable tablet with anti-helicobacter pylori containing broccoli extract / biochar complex consists of the following components by weight percentage: broccoli extract / biochar complex 5wt%, calcium carbonate 50wt%, dodecane 1.5wt% sodium hydroxysulfate, 0.75wt% peppermint oil, 0.05wt% mannitol, 0.8wt% sodium carboxymethylcellulose, 0.75wt% magnesium stearate.

[0051] The preparation method comprises the following steps:

[0052] (1) The broccoli extract / biochar composite, the calcium carbonate of 17wt% by weight percentage, sodium lauryl sulfate, peppermint oil, mannitol are ground and mixed, add sodium carboxymethyl cellulose and mix to make soft material ;

[0053] (2) pass through a 14-mesh sieve to make wet granules, and dry at 60-80°C;

[0054] (3) the dried particles pass through a 12-mesh sieve;

[0055] (4) After adding the remaining calcium carbonate and magnesium stearate, compress into tablets.

[0056] The preparation method of the broccoli...

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Abstract

The invention discloses a broccoli extract and biochar compound, biochar is prepared from residues after broccoli extraction, and a preparation method of the broccoli extract and biochar compound comprises the following steps: (1) dissolving 2-3mL of broccoli extract in an organic solvent; (2) adding 0.2-1.0 g of charcoal, uniformly mixing, and adjusting the pH value to 2.1-2.8; and (3) drying at 40-55 DEG C, and collecting the powder to obtain the broccoli extract charcoal compound. The invention also discloses application of the compound in preparation of an oral care product with helicobacter pylori resistance. The compound is simple in preparation method, stable in component, free of side effects, convenient to use and capable of directly going deep into the oral cavity, cleaning teeth and resisting common pathogenic bacteria in the oral cavity. The oral care product provided by the invention does not contain antibiotics, does not generate drug resistance, can obviously reduce colonization of helicobacter pylori in the oral cavity, and effectively prevents the oral cavity transmission path of helicobacter pylori.

Description

technical field [0001] The invention belongs to the technology of daily chemicals, and in particular relates to a broccoli extract and biochar composite, a preparation method and application thereof. Background technique [0002] Helicobacter pylori is a Gram-negative bacterium that is microanaerobic and requires very harsh growth conditions. Helicobacter pylori in the oral cavity mainly exists in dental plaque, and ordinary toothpaste is difficult to affect it, which usually causes bad breath, oral ulcers, periodontitis, chronic stomach diseases and other diseases. The current first-line therapy is to use the quadruple method , that is, proton pump inhibitors plus bismuth combined with two antibiotics, the curative effect is better; there are still some places still using triple therapy to treat Helicobacter pylori, that is, proton pump inhibitors plus clarithromycin combined with amoxicillin or metronidazole, The eradication rate of this therapy is mostly lower than 80%, ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/9789A61K8/19A61Q11/00A61K36/31A61K33/44A61P1/02A61P31/04A23G4/06A23G4/12
CPCA61K8/9789A61K8/19A61Q11/00A61K36/31A61K33/44A61P1/02A61P31/04A23G4/068A23G4/12A23V2002/00A61K2236/19A61K2800/805
Inventor 李曹龙王飞王璐
Owner CHINA PHARM UNIV
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